Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs

American Journal of Respiratory Cell and Molecular Biology

Volumn 52, Issue 6, 2015, Pages 683-694

  Keiser, Nicholas W ^a   Birket, Susan E ^b   Evans, Idil A ^a   Tyler, Scott R ^a   Crooke, Adrianne K ^a   Sun, Xingshen ^a   Zhou, Weihong ^a   Nellis, Joseph R ^a   Stroebele, Elizabeth K ^a   Chu, Kengyeh K ^c   Tearney, Guillermo J ^c   Stevens, Mark J ^d   Harris, J Kirk ^d   Rowe, Steven M ^b   Engelhardt, John F ^a  

^a UNIVERSITY OF IOWA   (United States)

^b University of Alabama at Birmingham   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d Children's Hospital Colorado   (United States)

Author keywords

Animal model; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Inflammation; Innate immunity

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; INITIATION FACTOR 2; INTERLEUKIN 8; MAMMALIAN TARGET OF RAPAMYCIN; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CYTOKINE; PROTEOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL LOAD; BIRTH; CESAREAN SECTION; COMPLEMENT SYSTEM; CONTROLLED STUDY; CYSTIC FIBROSIS; FEMALE; FERRET; GENOTYPE; HUMAN; INNATE IMMUNITY; LIQUID CHROMATOGRAPHY; LUNG LAVAGE; MACROPHAGE FUNCTION; NEWBORN; NONHUMAN; PH; PSEUDOMONAS; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS PSEUDINTERMEDIUS; TANDEM MASS SPECTROMETRY; ANIMAL; GENE INACTIVATION; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MUCOCILIARY CLEARANCE; PATHOLOGY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; TRACHEA;

ANIMALIA; BACTERIA (MICROORGANISMS); EUKARYOTA; MAMMALIA; MUSTELA; PSEUDOMONAS; STAPHYLOCOCCUS;

ANIMALS; ANIMALS, NEWBORN; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOKINES; FERRETS; GENE KNOCKOUT TECHNIQUES; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; MUCOCILIARY CLEARANCE; PROTEOME; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; TRACHEA;

EID: 84930409897     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2014-0250OC     Document Type: Article

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