Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis

Infection and Immunity

Volumn 70, Issue 4, 2002, Pages 1783-1790

  Erickson, David L ^a   Endersby, Ryan ^a   Kirkham, Amanda ^a   Stuber, Kent ^a   Vollman, Dolina D ^a   Rabin, Harvey R ^a   Mitchell, Ian ^a   Storey, Douglas G ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOSERINE; LACTONE; VIRULENCE FACTOR;

ADOLESCENT; ARTICLE; BACTERIAL VIRULENCE; BIOSENSOR; CLINICAL ARTICLE; CYSTIC FIBROSIS; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; LUNG INFECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; SIGNAL TRANSDUCTION; SPUTUM ANALYSIS;

BACTERIAL PROTEINS; CYSTIC FIBROSIS; DNA-BINDING PROTEINS; HUMANS; LUNG; METALLOENDOPEPTIDASES; PSEUDOMONAS AERUGINOSA; RNA, MESSENGER; TRANS-ACTIVATORS; VIRULENCE;

EID: 0036126980     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.4.1783-1790.2002     Document Type: Article

References (49)

1. A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography·mass spectrometry: Application to a model bacterial biofilm
2. RsaL, a novel repressor of virulence gene expression in Pseudomonas aeruginosa
3. Quorum-sensing genes in Pseudomonas aeruginosa biofilms: Their role and expression patterns
4. AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora
5. Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa
6. Kinetics of toxA and regA mRNA accumulation in Pseudomonas aeruginosa
7. Differential regulation by iron of regA and toxA transcript accumulation in Pseudomonas aeruginosa
8. Conserved cis-acting promoter elements are required for density-dependent transcription of Agrobacterium tumefaciens conjugal transfer genes
9. Census and consensus in bacterial ecosystems: The LuxR-LuxI family of quorum sensing transcriptional regulators
10. Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression
11. Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis
12. Burkholderia cepacia in cystic fibrosis
13. Relation between antibody response to Pseudomonas aeruginosa exoproteins and colonization/infection in patients with cystic fibrosis
14. Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): A target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis
15. Prospective study of serum antibodies to Pseudomonas aeruginosa exoproteins in cystic fibrosis
16. Detection by enzyme-linked immunosorbent assays of antibody specific for Pseudomonas proteases and exotoxin A in sera from cystic fibrosis patients
17. Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients
18. Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria
19. Novel synthetic analogs of the Pseudomonas autoinducer
20. Antibodies to proteases and exotoxin A of Pseudomonas aeruginosa in patients with cystic fibrosis: Demonstration by radioimmunoassay
21. Overexpression of the MexEF-OprN multidrug efflux system affects cell-to-cell signaling in Pseudomonas aeruginosa
22. Quorum sensing in Burkholderia cepacia: Identification of the LuxRI homologs CepRI
23. Kinetics of the acyl-homoserine lactone regulatory system in a model biofilm system: How many bacteria constitute a "quorum"?
24. Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa
25. Isolation and characterization of a Pseudomonas aeruginosa PAO mutant that produces altered elastase
26. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection
27. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication
28. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes
29. A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa
30. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes
31. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals
32. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa
33. The role of quorum sensing in the in vivo virulence of Pseudomonas aeruginosa
34. Pseudomonas aeniginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone inhibits expression of P2Y receptors in cystic fibrosis tracheal gland cells
35. Detecting and characterizing N-acyl-homoserine lactone signal molecules by thin-layer chromatography
36. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
37. Transformation of Pseudomonas aeruginosa by electroporation
38. Positive correlation of algD transcription to lasB and lasA transcription by populations of Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis
39. Population transcript accumulation of Pseudomonas aeruginosa exotoxin A and elastase in sputa from patients with cystic fibrosis
40. Pseudomonas aeruginosa lasR transcription correlates with the transcription of lasA, lasB, and toxA in chronic lung infections associated with cystic fibrosis
41. Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: A new family of genes responsible for autoinducer production
42. The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity
43. Thermosensitive step associated with transfer of the Ti plasmid during conjugation: Possible relation to transformation in crown gall
44. Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa
45. Pseudomonas aeruginosa mutations in lasI and rhlI quorum-sensing systems result in milder chronic lung infection
46. Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa
47. Analogs of the autoinducer 3-oxooctanoyl-homoserine lactone strongly inhibit activity of the TraR protein of Agrobacterium tumefaciens
48. Cystic fibrosis: Genotypic and phenotypic variations