Hydrogen cyanide concentrations in the breath of adult cystic fibrosis patients with and without Pseudomonas aeruginosa infection

Journal of Breath Research

Volumn 7, Issue 2, 2013, Pages

  Gilchrist, Francis J ^a,c   Bright Thomas, Rowland J ^b   Jones, Andrew M ^b   Smith, David ^c   Španěl, Patrik ^c,d   Webb, A Kevin ^b   Lenney, Warren ^a,c  

^a UNIVERSITY HOSPITAL OF NORTH STAFFORDSHIRE   (United Kingdom)

^b WYTHENSHAWE HOSPITAL   (United Kingdom)

^c KEELE UNIVERSITY   (United Kingdom)

^d J HEYROVSKÝ INSTITUTE OF PHYSICAL CHEMISTRY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; ALCOHOL; HYDROGEN CYANIDE; VOLATILE AGENT; BIOLOGICAL MARKER; DIAGNOSTIC AGENT;

ADULT; ARTICLE; BACTERIUM CULTURE; BREATH ANALYSIS; BREATHING; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DIAGNOSTIC TEST; DISEASE MARKER; EXPIRED AIR; HUMAN; MASS SPECTROMETRY; MOUTH; MOUTH EXHALED BREATH; NON INVASIVE PROCEDURE; NOSE BREATHING; NOSE EXHALED BREATH; PRIORITY JOURNAL; PSEUDOMONAS INFECTION; SELECTED ION FLOW MASS SPECTROMETRY; EXHALATION; FEMALE; FOLLOW UP; ISOLATION AND PURIFICATION; MALE; METABOLISM; METHODOLOGY; PSEUDOMONAS AERUGINOSA; YOUNG ADULT;

ACETONE; ADULT; BIOLOGICAL MARKERS; BREATH TESTS; CYSTIC FIBROSIS; EXHALATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDROGEN CYANIDE; MALE; MASS SPECTROMETRY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; YOUNG ADULT;

EID: 84878795516     PISSN: 17527155     EISSN: 17527163     Source Type: Journal    
DOI: 10.1088/1752-7155/7/2/026010     Document Type: Article

References (32)

1. Cystic Fibrosis Trust Registry 2010 Annual Data Report 2010 (Cystic Fibrosis Trust)
2. Aebi C, Bracher R, Liechti-Gallati S, Tschäppeler H, Rüdeberg A and Kraemer R 1995 The age at onset of chronic Pseudomonas aeruginosa colonization in cystic fibrosis - prognostic significance Eur. J. Pediatr. 154 (Suppl. 4) S69-73
3. Valerius N H, Koch C and Høiby N 1991 Prevention of chronic Pseudomonas aeruginosa colonisation in cystic fibrosis by early treatment Lancet 338 725-6
4. Taccetti G, Campana S, Festini F, Mascherini M and Döring G 2005 Early eradication therapy against Pseudomonas aeruginosa in cystic fibrosis patients Eur. Respir. J. 26 458-61 (Pubitemid 41264209)
5. Douglas T A et al 2009 Acquisition and eradication of P. aeruginosa in young children with cystic fibrosis Eur. Respir. J. 33 305-11
6. Rosenfeld M et al 1999 Diagnostic accuracy of oropharyngeal cultures in infants and young children with cystic fibrosis Pediatr. Pulmonol. 28 321-8 (Pubitemid 29523443)
7. De Boeck K, Alifier M and Vandeputte S 2000 Sputum induction in young cystic fibrosis patients Eur. Respir. J. 16 91-4 (Pubitemid 30480134)
8. Gilchrist F J, Salamat S, Clayton S, Peach J, Alexander J and Lenney W 2011 Bronchoalveolar lavage in children with cystic fibrosis: How many lobes should be sampled? Arch. Dis. Child. 96 215-7
9. Carroll W, Lenney W, Wang T, Španěl P, Alcock A and Smith D 2005 Detection of volatile compounds emitted by Pseudomonas aeruginosa using selected ion flow tube mass spectrometry Pediatr. Pulmonol. 39 452-6 (Pubitemid 40548288)
10. Williams H D, Zlosnik J E A and Ryall B 2007 Oxygen, cyanide and energy generation in the cystic fibrosis pathogen Pseudomonas aeruginosa Adv. Microb. Physiol. 52 1-71
11. Španěl P, Wang T and Smith D 2004 Quantification of hydrogen cyanide in humid air by selected ion flow tube mass spectrometry Rapid Commun. Mass Spectrom. 18 1869-73 (Pubitemid 39079141)
12. Španěl P, Dryahina K and Smith D 2007 Acetone, ammonia and hydrogen cyanide in exhaled breath of several volunteers aged 4-83 years J. Breath Res. 1 011001
13. Ryall B, Davies J C, Wilson R, Shoemark A and Williams H D 2008 Pseudomonas aeruginosa, cyanide accumulation and lung function in CF and non-CF bronchiectasis patients Eur. Respir. J. 32 740-7
14. Enderby B, Smith D, Carroll W and Lenney W 2009 Hydrogen cyanide as a biomarker for Pseudomonas aeruginosa in the breath of children with cystic fibrosis Pediatr. Pulmonol. 44 142-7
15. Enderby B, Lenney W, Brady M, Emmett C, Španěl P and Smith D 2009 Concentrations of some metabolites in the breath of healthy children aged 7-18 years measured using selected ion flow tube mass spectrometry (SIFT-MS) J. Breath Res. 3 036001
16. Gilchrist F J et al 2011 Variation in hydrogen cyanide production between different strains of Pseudomonas aeruginosa Eur. Respir. J. 38 409-14
17. Gilchrist F J, Sims H, Alcock A, Belcher J, Jones A M, Smith D, Španěl P, Webb A K and Lenney W 2012 Quantification of hydrogen cyanide and 2-aminoacetophenone in the headspace of Pseudomonas aeruginosa cultured under biofilm and planktonic conditions Anal. Methods 4 3661-5
18. Shestivska V, Nemec A, Dřevínek P, Sovová K, Dryahina K and Španěl P 2011 Quantification of methyl thiocyanate in the headspace of Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis patients by selected ion flow tube mass spectrometry Rapid Commun. Mass Spectrom. 25 2459-67
19. Savelev S U et al 2011 Volatile biomarkers of Pseudomonas aeruginosa in cystic fibrosis and noncystic fibrosis bronchiectasis Lett. Appl. Microbiol. 52 610-3
20. Shestivska V et al 2012 Variability in the concentrations of volatile metabolites emitted by genotypically different strains of Pseudomonas aeruginosa J. Appl. Microbiol. 113 701-13
21. Wang T, Pysanenko A, Dryahina K, Španěl P and Smith D 2008 Analysis of breath, exhaled via the mouth and nose, and the air in the oral cavity J. Breath Res. 2 037013
22. Španěl P and Smith D 2011 Progress in SIFT-MS: breath analysis and other applications Mass Spectrom. Rev. 30 236-67
23. Španěl P, Dryahina K and Smith D 2006 A general method for the calculation of absolute trace gas concentrations in air and breath from selected ion flow tube mass spectrometry data Int. J. Mass Spectrom. 249 230-9
24. Španěl P and Smith D 2001 On-line measurement of the absolute humidity of air, breath and liquid headspace samples by selection ion flow tube mass spectroscopy Rapid Commun. Mass Spectrom. 15 563-9 (Pubitemid 32391090)
25. Schmidt F M, Metsälä M, Vaittinen O and Halonen L 2011 Background levels and diurnal variations of hydrogen cyanide in breath and emitted from skin J. Breath Res. 5 046004
26. Turner C, Španěl P and Smith D 2006 A longitudinal study of ammonia, acetone and propanol in the exhaled breath of 30 subjects using selected ion flow tube mass spectrometry, SIFT-MS Physiol. Meas. 27 321-37
27. Španěl P, Dryahina K, Rejskova A, Chippendale T W E and Smith D 2011 Breath acetone concentration; biological variability and the influence of diet Physiol. Meas. 32 N23-31
28. Španěl P, Turner C, Wang T S, Bloor R and Smith D 2006 Generation of volatile compounds on mouth exposure to urea and sucrose: implications for exhaled breath analysis Physiol. Meas. 27 N7-17
29. Turner C, Španěl P and Smith D 2006 A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry, SIFT-MS Physiol. Meas. 27 637-48 (Pubitemid 43841053)
30. Montuschi P et al 2012 NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis Thorax 67 222-8
31. Dummer J et al 2013 Quantification of hydrogen cyanide (HCN) in breath using selected ion flow tube mass spectrometry - HCN is not a biomarker of Pseudomonas in chronic suppurative lung disease J. Breath Res. 7 017105
32. Smith D, Chippendale T W E, Dryahina K and Španěl P 2013 SIFT-MS analysis of nose-exhaled breath; mouth contamination and the influence of exercise at press