Molecular mechanism of the susceptibility difference between HLA-B*27:02/04/05 and HLA-B*27:06/09 to ankylosing spondylitis: substitution analysis, MD simulation, QSAR modelling, and in vitro assay

SAR and QSAR in Environmental Research

Volumn 27, Issue 5, 2016, Pages 409-425

  Cheng, X ^a   Mei, Y ^a   Ji, X ^a   Xue, Q ^a   Chen, D ^a  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

Ankylosing spondylitis; Antigenic peptide; HLA B27; Nurse; Quantitative structure activity relationship; Susceptibility

Indexed keywords

AMINO ACIDS; ANTIGENS; COMPUTATIONAL CHEMISTRY;

ANKYLOSING SPONDYLITI; ANTIGENIC PEPTIDES; HLA-B27; MD SIMULATION; MOLECULAR MECHANISM; NURSE; POSITIVELY CHARGED; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP; SUSCEPTIBILITY; SUSCEPTIBILITY DIFFERENCES;

PEPTIDES;

HLA B27 ANTIGEN; PEPTIDE; PROTEIN BINDING;

ANKYLOSING SPONDYLITIS; CHEMISTRY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR DYNAMICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

GENETIC PREDISPOSITION TO DISEASE; HLA-B27 ANTIGEN; HUMANS; MOLECULAR DYNAMICS SIMULATION; PEPTIDES; POLYMORPHISM, GENETIC; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPONDYLITIS, ANKYLOSING;

EID: 84975297406     PISSN: 1062936X     EISSN: 1029046X     Source Type: Journal    
DOI: 10.1080/1062936X.2016.1179672     Document Type: Article

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