High T cell epitope sharing between two HLA-B27 subtypes (B*2705 and B*2709) differentially associated to ankylosing spondylitis

Journal of Immunology

Volumn 163, Issue 4, 1999, Pages 2299-2305

  García Peydró, Marina ^a   Martí, Mercè ^a   López De Castro, José A ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; EPITOPE; HISTIDINE; HLA B27 ANTIGEN;

ALLOIMMUNITY; ANKYLOSING SPONDYLITIS; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE PREDISPOSITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

ALLELES; AMINO ACID SUBSTITUTION; CLONE CELLS; CYTOTOXICITY TESTS, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; HLA-B27 ANTIGEN; HUMANS; PEPTIDES; POINT MUTATION; SPONDYLITIS, ANKYLOSING; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION;

EID: 0345425057     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Brewerton, D. A., M. Caffrey, F. D. Hart, D. C. O. James, A. Nichols, and R. D. Sturrock. 1973. Ankylosing spondylitis and HL-A27. Lancet I:904.
2. Schlosstein, L., P. I. Terasaki, R. Bluestone, and C. M. Pearson. 1973. High association of an HL-A antigen, W27, with ankylosing spondylitis. N. Engl. J. Med. 288:704.
3. Kingsley, G., and J. Sieper. 1993. Current perspectives in reactive arthritis. Immunol. Today 14:387.
4. Lopez de Castro, J. A. 1998. The pathogenetic role of RLA-B27 in chronic arthritis. Curr. Opin. Immunol. 10:59.
5. Gonzalez-Roces, S., M. V. Alvarez, S. Gonzalez, A. Dieye, H. Makni, D. G. Woodfield, L. Housan, V. Konenkov, M. C. Abbadi, N. Grunnet, E. Coto, and C. Lopez-Larrea. 1997. HLA-B27 polymorphism and worldwide susceptibility to ankylosing spondylitis. Tissue Antigens 49:116.
6. Lopez-Larrea, C., K. Sujirachato, N. K. Mehra, P. Chiewsilp, D. Isarangkura, U. Kanga, O. Dominguez, E. Coto, M. Pena, and F. Setien. 1995. HLA-B27 subtypes in Asian patients with ankylosing spondylitis: evidence for new associations. Tissue Antigens 45:169.
7. Nasution, A. R., A. Mardjuadi, S. Kunmartini, N. G. Suryadhana, B. Setyohadi, D. Sudarsono, N. M. Lardy, and T. E. Feltkamp. 1997. HLA-B27 subtypes positively and negatively associated with spondytoarthropathy. J. Rheumatol. 24: 1111.
8. Ren, E. C., W. H. Koh, D. Sim, M. L. Boey, G. B. Wee, and S. H. Chan. 1997. Possible protective role of HLA-B*2706 for ankylosing spondylitis. Tissue Antigens 49:67.
9. D'Amato, M., M. T. Fiorillo, C. Carcassi, A. Mathieu, A. Zuccarelli, P. P. Bitti, R. Tosi, and R. Sorrentino. 1995. Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis. Eur. J. Immunol. 25:3199.
10. Benjamin, R., and P. Parham. 1990. Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol. Today 11:137.
11. Zhou, M., A. Sayad, W. A. Simmons, R. C. Jones, S. D. Maika, N. Satumtira, M. L. Dorris, S. J. Gaskell, R. S. Bordoli, R. B. Sartor, C. A. Slaughter, J. A. Richardson, R. E. Hammer, and J. D. Taurog. 1998. The specificity of peptides bound to human histocompatibility leukocyte antigen (HLA)-B27 influences the prevalence of arthritis in HLA-B27 transgenic rats. J. Exp. Med. 188: 877.
12. Lopez de Castro, J. A. 1995. Structural polymorphism and function of HLA-B27. Curr. Opin. Rheumatol. 7:270.
13. Jardetzky, T. S., W. S. Lane, R. A. Robinson, D. R. Madden, and D. C. Wiley. 1991. Identification of self peptides bound to purified HLA-B27. Nature 353:326.
14. Rotzschke, O., K. Falk, S. Stevanovic, V. Gnau, G. Jung, and H. G. Rammensee. 1994. Dominant aromatic/aliphatic C-terminal anchor in HLA-B*2702 and B*2705 peptide motifs. Immunogenetics 39:74.
15. Garcia, F., B. Galocha, J. A. Villadangos, J. R. Lamas, J. P. Albar, A. Marina, and J. A. Lopez de Castro. 1997. HLA-B27 (B*2701) specificity for peptides lacking Arg2 is determined by polymorphism outside the B pocket. Tissue Antigens 49: 580.
16. Boisgerault, F., V. Tieng, M. C. Stolzenberg, N. Dulphy, I. Khalil, R. Tamouza, D. Charron, and A. Toubert. 1996. Differences in endogenous peptides presented by HLA-B*2705 and B*2703 allelic variants: implications for susceptibility to spondylarthropathies. J. Clin. Invest. 98:2764.
17. Griffin, T. A., J. Yuan, T. Friede, S. Stevanovic, K. Ariyoshi, S. L. Rowland-Jones, H. G. Rammensee, and R. A. Colbert. 1997. Naturally occurring A pocket polymorphism in HLA-B*2703 increases the dependence on an accessory anchor residue at P1 for optimal binding of nonamer peptides. J. Immunol. 159:4887.
18. Garcia, F., A. Marina, and J. A. Lopez de Castro. 1997. Lack of carboxyl-terminal tyrosine distinguishes the B*2706-bound peptide repertoire from those of B*2704 and other HLA-B27 subtypes associated with ankylosing spondylitis. Tissue Antigens 49:215.
19. Tieng, V., N. Dulphy, F. Boisgerault, R. Tamouza, D. Charron, and A. Toubert. 1997. HLA-B*2707 peptide motif: Tyr C-terminal anchor is not shared by all disease-associated subtypes. Immunogenetics 47:103.
20. Fiorillo, M. T., L. Meadows, M. Damato, E. Appella, and R. Sorrentino. 1997. Susceptibility to ankylosing spondylitis correlates with the C-terminal residue of peptides presented by various HLA-B27 subtypes. Eur. J. Immunol. 27:368.
21. Garcia, F., D. Rognan, J. R. Lamas, A. Marina, and J. A. Lopez de Castro. 1998. An HLA-B27 polymorphism (B*2710) that is critical for T-cell recognition has limited effects on peptide specificity. Tissue Antigens 51:1.
22. Brooks, J. M., R. J. Murray, W. A. Thomas, M. G. Kurilla, and A. B. Rickinson. 1993. Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptide. J. Exp. Med. 178:879.
23. Brooks, J. M., R. A. Colbert, J. P. Mear, A. M. Leese, and A. B. Rickinson. 1998. HLA-B27 subtype polymorphism and CTL epitope choice: studies with EBV peptides link immunogenicity with stability of the B27: peptide complex. J. Immunol. 161:5252.
24. Lamas, J. R., J. M. Brooks, B. Galocha, A. B. Rickinson, and J. A. Lopez de Castro. 1998. Relationship between peptide binding and T cell epitope selection: a study with subtypes of HLA-B27. Int. Immunol. 10:259.
25. Rowland-Jones, S., R. A. Colbert, T. Dong, S. McAdam, M. Brown, K. Ariyoshi, S. Sabally, H. Whittle, and A. McMichael. 1998. Distinct recognition of closely-related HIV-1 and HIV-2 cytotoxic T- cell epitopes presented by HLA-B*2703 and B*2705. AIDS 12:1391.
26. Paradela, A., M. Garcia-Peydro, J. Vazquez, D. Rognan, and J. A. Lopez de Castro. 1998. The same natural ligand is involved in allorecognition of multiple HLA-B27 subtypes by a single T cell clone: role of peptide and the MHC molecule in alloreactivity. J. Immunol. 161:5481.
27. Lopez, D., R. Garcia Hoyo, and J. A. Lopez de Castro. 1994. Clonal analysis of alloreactive T cell responses against the closely related B*2705 and B*2703 subtypes: implications for HLA- B27 association to spondyloarthropathy. J. Immunol. 152:5557.
28. Del Porto, P., M. D'Amato, M. T. Fiorillo, L. Tuosto, E. Piccolella, and R. Sorrentino. 1994. Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic γδ T cell clone. J. Immunol. 153:3093.
29. Fiorillo, M. T., G. Greco, M. Maragno, I. Potolicchio, A. Monizio, M. L. Dupuis, and R. Sorrentino. 1998. The naturally occurring polymorphism Asp116→His116, differentiating the ankylosing spondylitis-associated HLA-B*2705 from the non-associated HLA-B*2709 subtype, influences peptide-speciflc CD8 T cell recognition. Eur. J. Immunol. 28:2508.
30. Calvo, V., S. Rojo, D. Lopez, B. Galocha, and J. A. Lopez de Castro. 1990. Structure and diversity of HLA-B27-specific T cell epitopes: analysis with site-directed mutants mimicking HLA-B27 subtype polymorphism. J. Immunol. 144: 4038.
31. Villadangos, J. A., B. Galocha, and J. A. Lopez de Castro. 1994. Unusual topology of an HLA-B27 allospecific T cell epitope lacking peptide specificity. J. Immunol. 152:2317.
32. Ellis, S. A., C. Taylor, and A. McMichael. 1982. Recognition of HLA-B27 and related antigen by a monoclonal antibody. Hum. Immunol. 5:49.
33. Villadangos, J. A., B. Galocha, F. Garcia, J. P. Albar, and J. A. Lopez de Castro. 1995. Modulation of peptide binding by HLA-B27 polymorphism in pockets A and B, and peptide specificity of B*2703. Eur. J. Immunol. 25:2370.
34. Jaraquemada, D., B. Galocha, P. Aparicio, S. Rojo, V. Calvo, and J. A. Lopez de Castro. 1988. Modulation on immunogenicity by HLA-B27 subtype polymorphism. Eur. J. Immunol. 18:1945.
35. Aparicio, P., D. Jaraquemada, and J. A. Lopez de Castro. 1987. Alloreactive cytolytic T cell clones with dual recognition of HLA-B27 and HLA-DR2 antigens: selective involvement of CD8 in their class I-directed cytotoxicity. J. Exp. Med. 165:428.
36. Villadangos, J. A., B. Galocha, R. Garcia-Hoyo, D. Lopez, F. Garcia, and J. A. Lopez de Castro. 1994. Structure of HLA-B27-specific T cell epitopes. Antigen presentation in B*2703 is limited mostly to a subset of the antigenic determinants on B*2705. Eur. J. Immunol. 24:2548.
37. Villadangos, J. A. 1994. Papel de residuos conservados y polimórficos de HLA-B27 en el reconocimiento por células T y en la unión de péptidos. Doctoral dissertation, Universidad Autónoma de Madrid, Spain.
38. Rammensee, H. G., T. Friede, and S. Stevanovic. 1995. MHC ligands and peptide motifs: first listing. Immunogenetics 41:178.
39. Lamas, J. R., A. Paradela, F. Roncal, and J. A. López de Castro. 1999. The peptide specificity of HLA-B27 subtypes differentially associated to ankylosing spondylitis is modulated at multiple anchor residues. Arthritis Rheum. In press.
40. Tallquist, M. D., and L. R. Pease. 1995. Alloreactive 2C T cells recognize a self peptide in the context of the mutant Kbm3 molecule. J. Immunol. 155:2419.
41. Tallquist, M. D., T. J. Yun, and L. R. Pease. 1996. A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity. J. Exp. Med. 184:1017.
42. Zhao, R., D. J. Loftus, E. Appella, and E. J. Collins. 1999. Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry. J. Exp. Med. 189:359.
43. Huet, S., D. F. Nixon, J. B. Rothbard, A. Townsend, S. A. Ellis, and A. J. McMichael. 1990. Structural homologies between two HLA B27-restricted peptides suggest residues important for interaction with HLA B27. Int. Immunol. 2:311.
44. Van Binnendijk, R. S., J. P. Versteeg van Oosten, M. C. Poelen, H. F. Brugghe, P. Hoogerhout, A. D. Osterhaus, and F. G. UytdeHaag. 1993. Human HLA class I- and HLA class II-restricted cloned cytotoxic T lymphocytes identify a cluster of epitopes on the measles virus fusion protein. J. Virol. 67:2276.
45. + T cell-targeted vaccine restimulates the memory CD4 T cell response but fails to induce cytotoxic T lymphocytes (CTL). Clin. Exp. Immunol. 105:18.
46. Goulder, P. J., R. E. Phillips, R. A. Colbert, S. McAdam, G. Ogg, M. A. Nowak, P. Giangrande, G. Luzzi, B. Morgan, A. Edwards, A. J. McMichael, and S. Rowland-Jones. 1997. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat. Med. 3:212.
47. Brown, M. A., L. G. Kennedy, A. J. MacGregor, C. Darke, E. Duncan, J. L. Shatford, A. Taylor, A. Calin, and P. Wordsworth. 1997. Susceptibility to ankylosing spondylitis in twins. The role of genes, HLA, and the environment. Arthritis Rheum. 40:1823.
48. Hill, A. V., C. E. Allsopp, D. Kwiatkowski, M. N. Anstey, B. M., Greenwood, and A. J. McMichael. 1991. HLA class I typing by PCR: HLA-B27 and African B27 subtype. Lancet 342:646.
49. Brown, M., A. Jepson, A. Young, H. Whittle, B. Greenwood, and P. Wordsworth. 1997. Spondyloarthritis in West Africa: evidence for a non-B27 protective effect. Ann. Rheum. Dis. 56:68.
50. Marchionni, L., V. Modena, R. Roggero, I. Ariata Maiocco, G. Mazzola, C. Lomater, M. Berrino, F. Btancatello, and E. S. Curtoni. 1999. The polymorphism of HLA-B27 and the seronegative spondyloarthropathies in the Italian population [abstract]. In 13th European Histocompatibility Conference, Crete, 1999. European Federation for Immunogenetics, p.36.