Rational design of YAP WW1 domain-binding peptides to target TGFβ/BMP/Smad-YAP interaction in heterotopic ossification

Journal of Peptide Science

Volumn 21, Issue 11, 2015, Pages 826-832

  Chen, Dong ^a   Liu, Shenghe ^a   Zhang, Wen ^a   Sun, Luyuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

heterotopic ossification; peptide; TGF BMP Smad signaling pathway; YAP WW1 domain

Indexed keywords

BONE MORPHOGENETIC PROTEIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; OLIGOPEPTIDE; PEPTIDE FRAGMENT; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; HETEROTOPIC OSSIFICATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG DESIGN; DRUG EFFECTS; ENERGY TRANSFER; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; OSSIFICATION, HETEROTOPIC; PROTEIN CONFORMATION; STATIC ELECTRICITY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BINDING SITES; BONE MORPHOGENETIC PROTEINS; COMPUTATIONAL BIOLOGY; DRUG DESIGN; ENERGY TRANSFER; EVOLUTION, MOLECULAR; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; OLIGOPEPTIDES; OSSIFICATION, HETEROTOPIC; PEPTIDE FRAGMENTS; PHOSPHOPROTEINS; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SIGNAL TRANSDUCTION; SMAD PROTEINS; STATIC ELECTRICITY; TRANSFORMING GROWTH FACTOR BETA;

EID: 84954524699     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.2824     Document Type: Article

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