A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers

Clinical Epigenetics

Volumn 8, Issue 1, 2016, Pages

  Diesch, Jeannine ^a   Zwick, Anabel ^b   Garz, Anne Kathrin ^b,c   Palau, Anna ^a   Buschbeck, Marcus ^a   Götze, Katharina S ^b,c  

^a JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE IJC   (Spain)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

AML; Azacitidine; Azanucleoside; Chromatin; Decitabine; HMA; MDS; Methylation

Indexed keywords

AZACITIDINE; AZANUCLEOSIDE DERIVATIVE; CYTARABINE; DAUNORUBICIN; DECITABINE; ENTINOSTAT; HISTONE DEACETYLASE INHIBITOR; LENALIDOMIDE; MOCETINOSTAT; PRACINOSTAT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE;

ACUTE MYELOBLASTIC LEUKEMIA; ALLOGENEIC STEM CELL TRANSPLANTATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ASXL1 GENE; BCL2L10 GENE; CANCER COMBINATION CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CANCER PROGNOSIS; CELL DIFFERENTIATION; CHROMATIN STRUCTURE; CHRONIC MYELOMONOCYTIC LEUKEMIA; CLINICAL PRACTICE; CLINICAL TRIAL (TOPIC); CYTOSTASIS; DNA ADDUCT; DNA DAMAGE; DNA METHYLATION; DNMT3A GENE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; DRUG SAFETY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG TOLERABILITY; EPIGENETICS; G2 PHASE CELL CYCLE CHECKPOINT; GENE; GENE THERAPY; HEMATOLOGIC MALIGNANCY; HIGH RISK PATIENT; HUMAN; IDH1 GENE; IDH2 GENE; IMMUNE RESPONSE; LEUKEMIA REMISSION; LEUKEMIA STEM CELL; LIPID HOMEOSTASIS; MAINTENANCE THERAPY; MAXIMUM PLASMA CONCENTRATION; MOLECULAR BIOLOGY; MONOTHERAPY; MYELODYSPLASTIC SYNDROME; NON SMALL CELL LUNG CANCER; OVERALL SURVIVAL; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REGULATORY T LYMPHOCYTE; REVIEW; RNA INTERFERENCE; S PHASE CELL CYCLE CHECKPOINT; STEM CELL; TET2 GENE; THROMBOCYTOPENIA; TP53 GENE; TREATMENT DURATION; ANALOGS AND DERIVATIVES; DRUG EFFECT; DRUG RESISTANCE; GENETIC EPIGENESIS; GENETICS; HEMATOLOGIC DISEASE; TREATMENT OUTCOME;

ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; CLINICAL TRIALS AS TOPIC; DECITABINE; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; EPIGENESIS, GENETIC; HEMATOLOGIC NEOPLASMS; HUMANS; TREATMENT OUTCOME;

EID: 84975275547     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/s13148-016-0237-y     Document Type: Review

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