The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism

Journal of Biological Chemistry

Volumn 289, Issue 27, 2014, Pages 18736-18751

  Poirier, Steve ^a,b   Samami, Samaneh ^a,b   Mamarbachi, Maya ^a   Demers, Annie ^a   Chang, T Yuan ^c   Vance, Dennis E ^d   Hatch, Grant M ^e   Mayer, Gaétan ^a,b  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF ALBERTA   (Canada)

^e UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY;

5-AZACYTIDINE; ANTICANCER DRUG; BIOSYNTHESIS PATHWAYS; CANCER THERAPEUTICS; LIPID HOMEOSTASIS; LIPID METABOLISMS; LIPID SYNTHESIS;

CHOLESTEROL;

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; CHOLESTEROL; CYTIDINE; FAT DROPLET; LIPID; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRIACYLGLYCEROL; URIDINE PHOSPHATE;

AGPAT9 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DNA METHYLATION; DOSE RESPONSE; DRUG POTENCY; DRUG SELECTIVITY; EMBRYO; ENZYME INHIBITION; FASN GENE; GENE; GENE EXPRESSION; HEPATOCELLULAR CARCINOMA CELL LINE; HMGCR GENE; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPID METABOLISM; LIPOGENESIS; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PCSK9 GENE; PRIORITY JOURNAL;

CHOLESTEROL METABOLISM; CTP; DE NOVO PYRIMIDINE SYNTHESIS; DNA METHYLATION; ENZYME INHIBITOR; GLYCEROLIPID; LIPID DROPLETS; PYRIMIDINE; STEROL REGULATORY ELEMENT-BINDING PROTEINS (SREBPS); UMP SYNTHASE;

ANIMALS; AZACITIDINE; CELL LINE, TUMOR; CELL NUCLEUS; CHOLESTEROL; CRICETINAE; DNA METHYLATION; EPIGENESIS, GENETIC; HOMEOSTASIS; HUMANS; LIVER; MALE; MICE; PYRIMIDINES; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

EID: 84903846196     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.563650     Document Type: Article

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