-
1
-
-
31344450167
-
Methylation inhibitor therapy in the treatment of myelodysplastic syndrome
-
Silverman LR, Mufti GJ. Methylation inhibitor therapy in the treatment of myelodysplastic syndrome. Nat Clin Pract Oncol 2005;2 Suppl 1:S12-23.
-
(2005)
Nat Clin Pract Oncol
, vol.2
, Issue.SUPPL. 1
-
-
Silverman, L.R.1
Mufti, G.J.2
-
2
-
-
34548414620
-
Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors
-
Appleton K, Mackay HJ, Judson I, et al. Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors. J Clin Oncol 2007;25:4603-9.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4603-4609
-
-
Appleton, K.1
Mackay, H.J.2
Judson, I.3
-
3
-
-
2642531973
-
Epigenetics in human disease and prospects for epigenetic therapy
-
Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004;429:457-63.
-
(2004)
Nature
, vol.429
, pp. 457-463
-
-
Egger, G.1
Liang, G.2
Aparicio, A.3
Jones, P.A.4
-
4
-
-
23844557794
-
Characterization of DNA demethylation effects induced by 5-aza-2′-deoxycytidine in patients with myelodysplastic syndrome
-
Mund C, Hackanson B, Stresemann C, Lubbert M, Lyko F. Characterization of DNA demethylation effects induced by 5-aza-2′-deoxycytidine in patients with myelodysplastic syndrome. Cancer Res 2005;65:7086-90.
-
(2005)
Cancer Res
, vol.65
, pp. 7086-7090
-
-
Mund, C.1
Hackanson, B.2
Stresemann, C.3
Lubbert, M.4
Lyko, F.5
-
5
-
-
33745714230
-
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
-
Gore SD, Baylin S, Sugar E, et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 2006;66:6361-9.
-
(2006)
Cancer Res
, vol.66
, pp. 6361-6369
-
-
Gore, S.D.1
Baylin, S.2
Sugar, E.3
-
6
-
-
54049147814
-
Azacytidine causes complex DNA methylation responses in myeloid leukemia
-
Stresemann C, Bokelmann I, Mahlknecht U, Lyko F. Azacytidine causes complex DNA methylation responses in myeloid leukemia. Mol Cancer Ther 2008;7:2998-3005.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2998-3005
-
-
Stresemann, C.1
Bokelmann, I.2
Mahlknecht, U.3
Lyko, F.4
-
7
-
-
33947430594
-
The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs
-
Zhang J, Visser F, King KM, Baldwin SA, Young JD, Cass CE. The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs. Cancer Metastasis Rev 2007;26:85-110.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 85-110
-
-
Zhang, J.1
Visser, F.2
King, K.M.3
Baldwin, S.A.4
Young, J.D.5
Cass, C.E.6
-
8
-
-
3042655528
-
Membrane transporters and channels: Role of the transportome in cancer chemosensitivity and chemoresistance
-
Huang Y, Anderle P, Bussey KJ, et al. Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Res 2004;64:4294-301.
-
(2004)
Cancer Res
, vol.64
, pp. 4294-4301
-
-
Huang, Y.1
Anderle, P.2
Bussey, K.J.3
-
9
-
-
1242340288
-
The concentrative nucleoside transporter family, SLC28
-
Gray JH, Owen RP, Giacomini KM. The concentrative nucleoside transporter family, SLC28. Pflugers Arch 2004;447:728-34.
-
(2004)
Pflugers Arch
, vol.447
, pp. 728-734
-
-
Gray, J.H.1
Owen, R.P.2
Giacomini, K.M.3
-
10
-
-
1242272722
-
The equilibrative nucleoside transporter family, SLC29
-
Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD. The equilibrative nucleoside transporter family, SLC29. Pflugers Arch 2004;447:735-43.
-
(2004)
Pflugers Arch
, vol.447
, pp. 735-743
-
-
Baldwin, S.A.1
Beal, P.R.2
Yao, S.Y.3
King, A.E.4
Cass, C.E.5
Young, J.D.6
-
11
-
-
0035021866
-
Complex regulation of nucleoside transporter expression in epithelial and immune system cells
-
Pastor-Anglada M, Casado FJ, Valdes R, Mata J, Garcia-Manteiga J, Molina M. Complex regulation of nucleoside transporter expression in epithelial and immune system cells. Mol Membr Biol 2001;18:81-5.
-
(2001)
Mol Membr Biol
, vol.18
, pp. 81-85
-
-
Pastor-Anglada, M.1
Casado, F.J.2
Valdes, R.3
Mata, J.4
Garcia-Manteiga, J.5
Molina, M.6
-
12
-
-
11844257006
-
-
Pastor-Anglada M, Cano-Soldado P, Molina-Arcas M, et al. Cell entry and export of nucleoside analogues. Virus Res 2005;107:151-64.
-
Pastor-Anglada M, Cano-Soldado P, Molina-Arcas M, et al. Cell entry and export of nucleoside analogues. Virus Res 2005;107:151-64.
-
-
-
-
13
-
-
0345299165
-
Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
-
Cui Y, König J, Buchholz JK, Spring H, Leier I, Keppler D. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol 1999;55:929-37.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 929-937
-
-
Cui, Y.1
König, J.2
Buchholz, J.K.3
Spring, H.4
Leier, I.5
Keppler, D.6
-
15
-
-
0037155204
-
Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2)
-
Sasaki M, Suzuki H, Ito K, Abe T, Sugiyama Y. Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2). J Biol Chem 2002;277:6497-503.
-
(2002)
J Biol Chem
, vol.277
, pp. 6497-6503
-
-
Sasaki, M.1
Suzuki, H.2
Ito, K.3
Abe, T.4
Sugiyama, Y.5
-
16
-
-
34548058440
-
Data-based mathematical modeling of vectorial transport across double-transfected polarized cells
-
Bartholome K, Rius M, Letschert K, Keller D, Timmer J, Keppler D. Data-based mathematical modeling of vectorial transport across double-transfected polarized cells. Drug Metab Dispos 2007;35:1476-81.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1476-1481
-
-
Bartholome, K.1
Rius, M.2
Letschert, K.3
Keller, D.4
Timmer, J.5
Keppler, D.6
-
18
-
-
0034984732
-
Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5′-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug
-
Mata JF, Garcia-Manteiga JM, Lostao MP, et al. Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5′-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug. Mol Pharmacol 2001;59:1542-8.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 1542-1548
-
-
Mata, J.F.1
Garcia-Manteiga, J.M.2
Lostao, M.P.3
-
19
-
-
0042766881
-
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane
-
Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D. Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology 2003;38:374-84.
-
(2003)
Hepatology
, vol.38
, pp. 374-384
-
-
Rius, M.1
Nies, A.T.2
Hummel-Eisenbeiss, J.3
Jedlitschky, G.4
Keppler, D.5
-
20
-
-
22244435605
-
Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
-
Brueckner B, Boy RG, Siedlecki P, et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res 2005;65:6305-11.
-
(2005)
Cancer Res
, vol.65
, pp. 6305-6311
-
-
Brueckner, B.1
Boy, R.G.2
Siedlecki, P.3
-
21
-
-
17144405378
-
Capillary electrophoretic analysis of genomic DNA methylation levels
-
Stach D, Schmitz OJ, Stilgenbauer S, et al. Capillary electrophoretic analysis of genomic DNA methylation levels. Nucleic Acids Res 2003;31:E2.
-
(2003)
Nucleic Acids Res
, vol.31
-
-
Stach, D.1
Schmitz, O.J.2
Stilgenbauer, S.3
-
22
-
-
0842347353
-
Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation
-
Weisenberger DJ, Velicescu M, Cheng JC, Gonzales FA, Liang G, Jones PA. Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. Mol Cancer Res 2004;2:62-72.
-
(2004)
Mol Cancer Res
, vol.2
, pp. 62-72
-
-
Weisenberger, D.J.1
Velicescu, M.2
Cheng, J.C.3
Gonzales, F.A.4
Liang, G.5
Jones, P.A.6
-
23
-
-
0020522019
-
Tissue-specific differences in DNA methylation in various mammals
-
Gama-Sosa MA, Midgett RM, Slagel VA, et al. Tissue-specific differences in DNA methylation in various mammals. Biochim Biophys Acta 1983;740:212-9.
-
(1983)
Biochim Biophys Acta
, vol.740
, pp. 212-219
-
-
Gama-Sosa, M.A.1
Midgett, R.M.2
Slagel, V.A.3
-
24
-
-
0037373891
-
A systematic profile of DNA methylation in human cancer cell lines
-
Paz MF, Fraga MF, Avila S, et al. A systematic profile of DNA methylation in human cancer cell lines. Cancer Res 2003;63:1114-21.
-
(2003)
Cancer Res
, vol.63
, pp. 1114-1121
-
-
Paz, M.F.1
Fraga, M.F.2
Avila, S.3
-
25
-
-
0014985960
-
Transport as the rate-limiting step in the incorporation of uridine into mengovirus ribonucleic acid in Novikoff rat hepatoma cells
-
Plagemann PG, Shea MA. Transport as the rate-limiting step in the incorporation of uridine into mengovirus ribonucleic acid in Novikoff rat hepatoma cells. J Virol 1971;7:137-43.
-
(1971)
J Virol
, vol.7
, pp. 137-143
-
-
Plagemann, P.G.1
Shea, M.A.2
-
26
-
-
43949136445
-
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
-
Stresemann C, Lyko F. Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine. Int J Cancer 2008;123:8-13.
-
(2008)
Int J Cancer
, vol.123
, pp. 8-13
-
-
Stresemann, C.1
Lyko, F.2
-
27
-
-
0142219312
-
Nucleoside transporter profiles in human pancreatic cancer cells: Role of hCNT1 in 2′,2′-difluorodeoxycytidine-induced cytotoxicity
-
Garcia-Manteiga J, Molina-Arcas M, Casado FJ, Mazo A, Pastor-Anglada M. Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2′,2′-difluorodeoxycytidine-induced cytotoxicity. Clin Cancer Res 2003;9:5000-8.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5000-5008
-
-
Garcia-Manteiga, J.1
Molina-Arcas, M.2
Casado, F.J.3
Mazo, A.4
Pastor-Anglada, M.5
-
28
-
-
33746656174
-
Expression of the high-affinity fluoropyrimidine-preferring nucleoside transporter hCNT1 correlates with decreased disease-free survival in breast cancer
-
Gloeckner-Hofmann K, Guillen-Gomez E, Schmidtgen C, et al. Expression of the high-affinity fluoropyrimidine-preferring nucleoside transporter hCNT1 correlates with decreased disease-free survival in breast cancer. Oncology 2006;70:238-44.
-
(2006)
Oncology
, vol.70
, pp. 238-244
-
-
Gloeckner-Hofmann, K.1
Guillen-Gomez, E.2
Schmidtgen, C.3
-
29
-
-
0030824757
-
Sodium-dependent nucleoside transport in the human intestinal brush-border membrane
-
Patil SD, Unadkat JD. Sodium-dependent nucleoside transport in the human intestinal brush-border membrane. Am J Physiol 1997;272:G1314-20.
-
(1997)
Am J Physiol
, vol.272
-
-
Patil, S.D.1
Unadkat, J.D.2
-
31
-
-
0034095947
-
Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1
-
Graham KA, Leithoff J, Coe IR, et al. Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1. Nucleosides Nucleotides Nucleic Acids 2000;19:415-34.
-
(2000)
Nucleosides Nucleotides Nucleic Acids
, vol.19
, pp. 415-434
-
-
Graham, K.A.1
Leithoff, J.2
Coe, I.R.3
-
32
-
-
0034666069
-
Electrogenic uptake of nucleosides and nucleoside-derived drugs by the human nucleoside transporter 1 (hCNT1) expressed in Xenopus laevis oocytes
-
Lostao MP, Mata JF, Larrayoz IM, Inzillo SM, Casado FJ, Pastor-Anglada M. Electrogenic uptake of nucleosides and nucleoside-derived drugs by the human nucleoside transporter 1 (hCNT1) expressed in Xenopus laevis oocytes. FEBS Lett 2000;481:137-40.
-
(2000)
FEBS Lett
, vol.481
, pp. 137-140
-
-
Lostao, M.P.1
Mata, J.F.2
Larrayoz, I.M.3
Inzillo, S.M.4
Casado, F.J.5
Pastor-Anglada, M.6
-
33
-
-
0018104806
-
Metabolism and cytotoxicity of 5-azacytidine in cultured Novikoff rat hepatoma and P388 mouse leukemia cells and their enhancement by preincubation with pyrazofurin
-
Plagemann PG, Behrens M, Abraham D. Metabolism and cytotoxicity of 5-azacytidine in cultured Novikoff rat hepatoma and P388 mouse leukemia cells and their enhancement by preincubation with pyrazofurin. Cancer Res 1978;38:2458-66.
-
(1978)
Cancer Res
, vol.38
, pp. 2458-2466
-
-
Plagemann, P.G.1
Behrens, M.2
Abraham, D.3
-
34
-
-
0034995859
-
+-dependent nucleoside transporter (CNT) family: Identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)
-
+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). Mol Membr Biol 2001;18:65-72.
-
(2001)
Mol Membr Biol
, vol.18
, pp. 65-72
-
-
Ritzel, M.W.1
Ng, A.M.2
Yao, S.Y.3
-
35
-
-
33645086120
-
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines
-
Stresemann C, Brueckner B, Musch T, Stopper H, Lyko F. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 2006;66:2794-800.
-
(2006)
Cancer Res
, vol.66
, pp. 2794-2800
-
-
Stresemann, C.1
Brueckner, B.2
Musch, T.3
Stopper, H.4
Lyko, F.5
-
36
-
-
33748998743
-
Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival
-
Egger G, Jeong S, Escobar SG, et al. Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival. Proc Natl Acad Sci U S A 2006;103:14080-5.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 14080-14085
-
-
Egger, G.1
Jeong, S.2
Escobar, S.G.3
-
37
-
-
33847348016
-
DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells
-
Spada F, Haemmer A, Kuch D, et al. DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells. J Cell Biol 2007;176:565-71.
-
(2007)
J Cell Biol
, vol.176
, pp. 565-571
-
-
Spada, F.1
Haemmer, A.2
Kuch, D.3
|