-
1
-
-
70349459734
-
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
-
Ablasser, A., Bauernfeind, F., Hartmann, G., et al. (2009). RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat. Immunol. 10, 1065-1072.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 1065-1072
-
-
Ablasser, A.1
Bauernfeind, F.2
Hartmann, G.3
-
2
-
-
76449098262
-
PHENIX: A comprehensive Python-based system for macromolecular structure solution
-
Adams, P.D., Afonine, P.V., Bunkoczi, G., et al. (2010). PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr. D Biol. Crystallogr. 66, 213-221.
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
Afonine, P.V.2
Bunkoczi, G.3
-
3
-
-
84860273177
-
Towards automated crystallographic structure refinement with phenix.refine
-
Afonine, P.V., Grosse-Kunstleve, R.W., Echols, N., et al. (2012). Towards automated crystallographic structure refinement with phenix.refine. Acta Crystallogr. D Biol. Crystallogr. 68, 352-367.
-
(2012)
Acta Crystallogr. D Biol. Crystallogr.
, vol.68
, pp. 352-367
-
-
Afonine, P.V.1
Grosse-Kunstleve, R.W.2
Echols, N.3
-
4
-
-
9144269673
-
A member of the Pyrin family, IFI16, is a novelBRCA1-associated protein involved in the p53-mediated apoptosis pathway
-
Aglipay, J.A., Lee, S.W., Okada, S., et al. (2003). A member of the Pyrin family, IFI16, is a novelBRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 22, 8931-8938.
-
(2003)
Oncogene
, vol.22
, pp. 8931-8938
-
-
Aglipay, J.A.1
Lee, S.W.2
Okada, S.3
-
5
-
-
77949940198
-
Intracellular toll-like receptors
-
Blasius, A.L., and Beutler, B. (2010). Intracellular toll-like receptors. Immunity 32, 305-315.
-
(2010)
Immunity
, vol.32
, pp. 305-315
-
-
Blasius, A.L.1
Beutler, B.2
-
6
-
-
84862279094
-
Preferential binding of IFI16 protein to cruciform structure and superhelical DNA
-
Brazda, V., Coufal, J., Liao, J.C.C., et al. (2012). Preferential binding of IFI16 protein to cruciform structure and superhelical DNA. Biochem. Biophys. Res. Commun. 422, 716-720.
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.422
, pp. 716-720
-
-
Brazda, V.1
Coufal, J.2
Liao, J.C.C.3
-
7
-
-
84870275730
-
Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
-
Brunette, R.L., Young, J.M., Whitley, D.G., et al. (2012). Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. J. Exp. Med. 209, 1969-1983.
-
(2012)
J. Exp. Med.
, vol.209
, pp. 1969-1983
-
-
Brunette, R.L.1
Young, J.M.2
Whitley, D.G.3
-
8
-
-
60749136484
-
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
-
Burckstummer, T., Baumann, C., Bluml, S., et al. (2009). An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10, 266-272.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 266-272
-
-
Burckstummer, T.1
Baumann, C.2
Bluml, S.3
-
9
-
-
74549178560
-
MolProbity: All-atom structure validation for macromolecular crystallography
-
Chen, V.B., Arendall, W.B., III, Headd, J.J., et al. (2010). MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr. D Biol. Crystallogr. 66, 12-21.
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 12-21
-
-
Chen, V.B.1
Arendall, W.B.2
Headd, J.J.3
-
10
-
-
68049092912
-
RNA polymerase III detects cytosolic DNA and induces type i interferons through the RIG-I pathway
-
Chiu, Y.H., Macmillan, J.B., and Chen, Z.J. (2009). RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138, 576-591.
-
(2009)
Cell
, vol.138
, pp. 576-591
-
-
Chiu, Y.H.1
Macmillan, J.B.2
Chen, Z.J.3
-
11
-
-
84878572947
-
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
-
Diner, E.J., Burdette, D.L., Wilson, S.C., et al. (2013). The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep. 3, 1355-1361.
-
(2013)
Cell Rep.
, vol.3
, pp. 1355-1361
-
-
Diner, E.J.1
Burdette, D.L.2
Wilson, S.C.3
-
13
-
-
63649145255
-
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
-
Fernandes-Alnemri, T., Yu, J.W., Datta, P., et al. (2009). AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458, 509-513.
-
(2009)
Nature
, vol.458
, pp. 509-513
-
-
Fernandes-Alnemri, T.1
Yu, J.W.2
Datta, P.3
-
14
-
-
84878309796
-
Cyclic [G(2′,5′)pA(3′ ,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
-
Gao, P., Ascano, M., Wu, Y., et al. (2013a). Cyclic [G(2′,5′)pA(3′ ,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153, 1094-1107.
-
(2013)
Cell
, vol.153
, pp. 1094-1107
-
-
Gao, P.1
Ascano, M.2
Wu, Y.3
-
15
-
-
84882815198
-
Structure-function analysis of STING activation by c[G(2′ ,5′)pA(3′ ,5′)p] and targeting by antiviral DMXAA
-
Gao, P., Ascano, M., Zillinger, T., et al. (2013b). Structure-function analysis of STING activation by c[G(2′ ,5′)pA(3′ ,5′)p] and targeting by antiviral DMXAA. Cell 154, 748-762.
-
(2013)
Cell
, vol.154
, pp. 748-762
-
-
Gao, P.1
Ascano, M.2
Zillinger, T.3
-
16
-
-
75649106430
-
Intracellular DNA recognition
-
Hornung, V., and Latz, E. (2010). Intracellular DNA recognition. Nat. Rev. Immunol. 10, 123-130.
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 123-130
-
-
Hornung, V.1
Latz, E.2
-
17
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
-
Hornung, V., Ablasser, A., Charrel-Dennis, M., et al. (2009). AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458, 514-518.
-
(2009)
Nature
, vol.458
, pp. 514-518
-
-
Hornung, V.1
Ablasser, A.2
Charrel-Dennis, M.3
-
18
-
-
33749490571
-
Innate immune recognition of, and regulation by, DNA
-
Ishii, K.J., and Akira, S. (2006). Innate immune recognition of, and regulation by, DNA. Trends Immunol. 27, 525-532.
-
(2006)
Trends Immunol.
, vol.27
, pp. 525-532
-
-
Ishii, K.J.1
Akira, S.2
-
19
-
-
84878539440
-
Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential
-
Jiao, L., Ouyang, S., Liang, M., et al. (2013). Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential. J. Virol. 87, 6829-6839.
-
(2013)
J. Virol.
, vol.87
, pp. 6829-6839
-
-
Jiao, L.1
Ouyang, S.2
Liang, M.3
-
20
-
-
84923861242
-
Mechanism of the Rpn13-induced activation of Uch37
-
Jiao, L., Ouyang, S., Shaw, N., et al. (2014). Mechanism of the Rpn13-induced activation of Uch37. Protein Cell 5, 616-630.
-
(2014)
Protein Cell
, vol.5
, pp. 616-630
-
-
Jiao, L.1
Ouyang, S.2
Shaw, N.3
-
21
-
-
84859986329
-
Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
-
Jin, T., Perry, A., Jiang, J., et al. (2012). Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 36, 561-571.
-
(2012)
Immunity
, vol.36
, pp. 561-571
-
-
Jin, T.1
Perry, A.2
Jiang, J.3
-
22
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
-
Kawai, T., and Akira, S. (2010). The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
23
-
-
79956061094
-
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
-
Kerur, N., Veettil, M.V., Sharma-Walia, N., et al. (2011). IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 9, 363-375.
-
(2011)
Cell Host Microbe
, vol.9
, pp. 363-375
-
-
Kerur, N.1
Veettil, M.V.2
Sharma-Walia, N.3
-
24
-
-
77957009390
-
Aspartate-glutamate-alaninehistidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
-
Kim, T., Pazhoor, S., Bao, M., et al. (2010). Aspartate-glutamate-alaninehistidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc. Natl Acad. Sci. USA 107, 15181-15186.
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 15181-15186
-
-
Kim, T.1
Pazhoor, S.2
Bao, M.3
-
25
-
-
34548232365
-
Inference of macromolecular assemblies from crystalline state
-
Krissinel, E., and Henrick, K. (2007). Inference of macromolecular assemblies from crystalline state. J. Mol. Biol. 372, 774-797.
-
(2007)
J. Mol. Biol.
, vol.372
, pp. 774-797
-
-
Krissinel, E.1
Henrick, K.2
-
26
-
-
37349121133
-
Model preparation in MOLREP and examples of model improvement using X-ray data
-
Lebedev, A.A., Vagin, A.A., and Murshudov, G.N. (2008). Model preparation in MOLREP and examples of model improvement using X-ray data. Acta Crystallogr. D Biol. Crystallogr. 64, 33-39.
-
(2008)
Acta Crystallogr. D Biol. Crystallogr.
, vol.64
, pp. 33-39
-
-
Lebedev, A.A.1
Vagin, A.A.2
Murshudov, G.N.3
-
27
-
-
79952468076
-
Interferon-inducible protein 16: Insight into the interaction with tumor suppressor p53
-
Liao, J.C.C., Lam, R., Brazda, V., et al. (2011). Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53. Structure 19, 418-429.
-
(2011)
Structure
, vol.19
, pp. 418-429
-
-
Liao, J.C.C.1
Lam, R.2
Brazda, V.3
-
28
-
-
0042512008
-
Homology modeling provides insights into the binding mode of the PAAD/DAPIN/pyrin domain, a fourth member of the CARD/DD/DED domain family
-
Liu, T., Rojas, A., Ye, Y., et al. (2003). Homology modeling provides insights into the binding mode of the PAAD/DAPIN/pyrin domain, a fourth member of the CARD/DD/DED domain family. Protein Sci. 12, 1872-1881.
-
(2003)
Protein Sci.
, vol.12
, pp. 1872-1881
-
-
Liu, T.1
Rojas, A.2
Ye, Y.3
-
29
-
-
84891933102
-
Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy
-
Morrone, S.R., Wang, T., Constantoulakis, L.M., et al. (2014). Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy. Proc. Natl Acad. Sci. USA 111, E62-E71.
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. E62-E71
-
-
Morrone, S.R.1
Wang, T.2
Constantoulakis, L.M.3
-
30
-
-
0030924992
-
Refinement of macromolecular structures by themaximum-likelihood method
-
Murshudov, G.N., Vagin, A.A., and Dodson, E.J. (1997). Refinement of macromolecular structures by themaximum-likelihood method. Acta Crystallogr.DBiol. Crystallogr. 53, 240-255.
-
(1997)
Acta Crystallogr.DBiol. Crystallogr.
, vol.53
, pp. 240-255
-
-
Murshudov, G.N.1
Vagin, A.A.2
Dodson, E.J.3
-
31
-
-
40449097257
-
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
-
Muruve, D.A., Petrilli, V., Zaiss, A.K., et al. (2008). The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452, 103-107.
-
(2008)
Nature
, vol.452
, pp. 103-107
-
-
Muruve, D.A.1
Petrilli, V.2
Zaiss, A.K.3
-
32
-
-
84888122810
-
Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA
-
Orzalli, M.H.,Conwell, S.E., Berrios, C., et al. (2013). Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA. Proc. Natl Acad. Sci. USA 110, E4492-E4501.
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. E4492-E4501
-
-
Orzalli, M.H.1
Conwell, S.E.2
Berrios, C.3
-
33
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Otwinowski, Z., and Minor, W. (1997). Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326.
-
(1997)
Methods Enzymol.
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
34
-
-
84865136571
-
Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus
-
Ouyang, S., Gong, B., Li, J.Z., et al. (2012). Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus. J. Mol. Med. 90, 837-846.
-
(2012)
J. Mol. Med.
, vol.90
, pp. 837-846
-
-
Ouyang, S.1
Gong, B.2
Li, J.Z.3
-
35
-
-
60749104535
-
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
-
Roberts, T.L., Idris, A., Dunn, J.A., et al. (2009). HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 323, 1057-1060.
-
(2009)
Science
, vol.323
, pp. 1057-1060
-
-
Roberts, T.L.1
Idris, A.2
Dunn, J.A.3
-
36
-
-
84878745041
-
Structural basis for termination of AIM2-mediated signaling by p202
-
Ru, H., Ni, X., Zhao, L., et al. (2013). Structural basis for termination of AIM2-mediated signaling by p202. Cell Res. 23, 855-858.
-
(2013)
Cell Res.
, vol.23
, pp. 855-858
-
-
Ru, H.1
Ni, X.2
Zhao, L.3
-
37
-
-
80052152283
-
The PYHIN protein family as mediators of host defenses
-
Schattgen, S.A., and Fitzgerald, K.A. (2011). The PYHIN protein family as mediators of host defenses. Immunol. Rev. 243, 109-118.
-
(2011)
Immunol. Rev.
, vol.243
, pp. 109-118
-
-
Schattgen, S.A.1
Fitzgerald, K.A.2
-
38
-
-
84874825627
-
Binding of bacterial secondary messenger molecule c di-GMP is a STING operation
-
Shaw, N., Ouyang, S., and Liu, Z.-J. (2012). Binding of bacterial secondary messenger molecule c di-GMP is a STING operation. Protein Cell 4, 117-129.
-
(2012)
Protein Cell
, vol.4
, pp. 117-129
-
-
Shaw, N.1
Ouyang, S.2
Liu, Z.-J.3
-
39
-
-
84873711885
-
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type i interferon pathway
-
Sun, L., Wu, J., Du, F., et al. (2013). Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786-791.
-
(2013)
Science
, vol.339
, pp. 786-791
-
-
Sun, L.1
Wu, J.2
Du, F.3
-
40
-
-
34547143110
-
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
-
Takaoka, A., Wang, Z., Choi, M.K., et al. (2007). DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448, 501-505.
-
(2007)
Nature
, vol.448
, pp. 501-505
-
-
Takaoka, A.1
Wang, Z.2
Choi, M.K.3
-
41
-
-
77958140656
-
IFI16 is an innate immune sensor for intracellular DNA
-
Unterholzner, L., Keating, S.E., Baran, M., et al. (2010). IFI16 is an innate immune sensor for intracellular DNA. Nat. Immunol. 11, 997-1004.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 997-1004
-
-
Unterholzner, L.1
Keating, S.E.2
Baran, M.3
-
42
-
-
52449135474
-
RPA nucleic acid-binding properties of IFI16-HIN200
-
Yan, H., Dalal, K., Hon, B.K., et al. (2008). RPA nucleic acid-binding properties of IFI16-HIN200. Biochim. Biophys. Acta 1784, 1087-1097.
-
(2008)
Biochim. Biophys. Acta
, vol.1784
, pp. 1087-1097
-
-
Yan, H.1
Dalal, K.2
Hon, B.K.3
-
43
-
-
77952566304
-
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type i interferon via a beta-catenin-dependent pathway
-
Yang, P., An, H., Liu, X., et al. (2010). The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat. Immunol. 11, 487-494.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 487-494
-
-
Yang, P.1
An, H.2
Liu, X.3
-
44
-
-
79959344720
-
DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells
-
Zhang, Z., Kim, T., Bao, M., et al. (2011a). DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity 34, 866-878.
-
(2011)
Immunity
, vol.34
, pp. 866-878
-
-
Zhang, Z.1
Kim, T.2
Bao, M.3
-
45
-
-
80052969639
-
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
-
Zhang, Z., Yuan, B., Bao, M., et al. (2011b). The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat. Immunol. 12, 959-965.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 959-965
-
-
Zhang, Z.1
Yuan, B.2
Bao, M.3
-
46
-
-
80555133355
-
DHX9 pairs with IPS-1 to sense doublestranded RNA in myeloid dendritic cells
-
Zhang, Z., Yuan, B., Lu, N., et al. (2011c). DHX9 pairs with IPS-1 to sense doublestranded RNA in myeloid dendritic cells. J. Immunol. 187, 4501-4508.
-
(2011)
J. Immunol.
, vol.187
, pp. 4501-4508
-
-
Zhang, Z.1
Yuan, B.2
Lu, N.3
-
47
-
-
84880508067
-
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING
-
Zhang, X., Shi, H., Wu, J., et al. (2013). Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 51, 226-235.
-
(2013)
Mol. Cell
, vol.51
, pp. 226-235
-
-
Zhang, X.1
Shi, H.2
Wu, J.3
-
48
-
-
84897632293
-
Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage
-
Zhao, L., Hua, T., Crowley, C., et al. (2014). Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res. 24, 344-358.
-
(2014)
Cell Res.
, vol.24
, pp. 344-358
-
-
Zhao, L.1
Hua, T.2
Crowley, C.3
|