Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus

Journal of Molecular Medicine

Volumn 90, Issue 7, 2012, Pages 837-846

  Ouyang, Songying ^a   Gong, Bin ^b   Li, Jin Zhi ^c   Zhao, Li Xia ^a   Wu, Wei ^b   Zhang, Fu Shun ^b   Sun, Lina ^b   Wang, Shu Jun ^c   Pan, Meng ^c   Li, Chuan ^b   Liang, Wenguang ^a,b   Shaw, Neil ^a   Zheng, Jie ^c   Zhao, Guo Ping ^d   Wang, Ying ^c,d   Liu, Zhi Jie ^a   Liang, Mifang ^b  

^a INSTITUTE OF BIOPHYSICS   (China)

^b National Institute for Viral Disease Control and Prevention   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

Author keywords

Crystal structure; Epitope; Human antibody; IFN ; Systemic lupus erythematosus (SLE)

Indexed keywords

ALPHA INTERFERON; ALPHA1B INTERFERON; ALPHA1B INTERFERON ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERFERON ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY STRUCTURE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GENE EXPRESSION REGULATION; HUMAN; IMMUNOTHERAPY; MOUSE; NONHUMAN; RECEPTOR AFFINITY; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODY AFFINITY; ANTIGEN-ANTIBODY COMPLEX; DISEASE MODELS, ANIMAL; HUMANS; INTERFERON-ALPHA; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; SIGNAL TRANSDUCTION; SINGLE-CHAIN ANTIBODIES;

EID: 84865136571     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0866-3     Document Type: Article

References (34)

1. Giffords ED (2003) Understanding and managing systemic lupus erythematosus (SLE). Soc Work Health Care 37:57-72 (Pubitemid 37371815)
2. Lahita R (1999) The clinical presentation of systemic lupus erythematosus. Academic, San Diego
3. Flesher DL, Sun X, Behrens TW, Graham RR, Criswell LA (2010) Recent advances in the genetics of systemic lupus erythematosus. Expert Rev Clin Immunol 6:461-479
4. Obermoser G, Pascual V (2010) The interferon-alpha signature of systemic lupus erythematosus. Lupus 19:1012-1019
5. Rahman A, Isenberg DA (2008) Systemic lupus erythematosus. N Engl J Med 358:929-939 (Pubitemid 351397092)
6. Ronnblom L, Elkon KB (2010) Cytokines as therapeutic targets in SLE. Nat Rev Rheumatol 6:339-347
7. Banchereau J, Pascual V (2006) Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 25:383-392 (Pubitemid 44354221)
8. Pascual V, Farkas L, Banchereau J (2006) Systemic lupus erythematosus: all roads lead to type I interferons. Curr Opin Immunol 18:676-682 (Pubitemid 44635182)
9. Ronnblom L, Alm GV, Eloranta ML (2009) Type I interferon and lupus. Curr Opin Rheumatol 21:471-477
10. Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J, Banchereau J, Pascual V (2003) Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 197:711-723 (Pubitemid 36350866)
11. Reddy MV, Velazquez-Cruz R, Baca V, Lima G, Granados J, Orozco L, Alarcon-Riquelme ME (2007) Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans. Hum Genet 121:721-727 (Pubitemid 46916971)
12. Kim T, Kanayama Y, Negoro N, Okamura M, Takeda T, Inoue T (1987) Serum levels of interferons in patients with systemic lupus erythematosus. Clin Exp Immunol 70:562-569 (Pubitemid 18013195)
13. Pascual V, Allantaz F, Patel P, Palucka AK, Chaussabel D, Banchereau J (2008) How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets. Immunol Rev 223:39-59 (Pubitemid 351986188)
14. Chuntharapai A, Lai J, Huang X, Gibbs V, Kim KJ, Presta LG, Stewart TA (2001) Characterization and humanization of a monoclonal antibody that neutralizes human leukocyte interferon: a candidate therapeutic for IDDM and SLE. Cytokine 15:250-260 (Pubitemid 34587638)
15. Sheets MD, Amersdorfer P, Finnern R, Sargent P, Lindquist E, Schier R, Hemingsen G, Wong C, Gerhart JC, Marks JD (1998) Efficient construction of a large nonimmune phage antibody library: the production of high-affinity human single-chain antibodies to protein antigens. Proc Natl Acad Sci U S A 95:6157-6162 (Pubitemid 28248981)
16. Liang M, Dübel S, Li D, Queitsch I, Li W, Bautz EK (2001) Baculovirus expression cassette vectors for rapid production of complete human IgG from phage display selected antibody fragments. J Immunol Methods 247:119-130 (Pubitemid 32057050)
17. Long F, Vagin AA, Young P, Murshudov GN (2008) BALBES: a molecular-replacement pipeline. Acta Crystallogr D: Biol Crystallogr 64:125-132 (Pubitemid 350308686)
18. Gong B, Wang S, Li C, Wang Y, Zhang Q, Chen Z, Sun L, Liang M, Sun Z, Li D (2009) Antibody against human interferon alb from human synthetic recombinant antibody library. Chin Med Biotechnol 4:184-189 [in Chinese]
19. Otwinowski ZMW (1997) Processing of X-ray diffraction data collected in oscillation mode. Academic, New York
20. Hillig RC, Urlinger S, Fanghanel J, Brocks B, Haenel C, Stark Y, Sulzle D, Svergun DI, Baesler S, Malawski G et al (2008) Fab MOR03268 triggers absorption shift of a diagnostic dye via packaging in a solvent-shielded Fab dimer interface. J Mol Biol 377:206-219
21. Niemi MH, Takkinen K, Amundsen L, Söderlund H, Rouvinen J, Höyhtyä M (2010) The testosterone binding mechanism of an antibody derived from a naïve human scFv library. J Mol Recog 24:209-219
22. Radhakrishnan R, Walter LJ, Subramaniam PS, Johnson HM, Walter MR (1999) Crystal structure of ovine interferon-tau at 2.1 Å resolution. J Mol Biol 286:151-162 (Pubitemid 29078402)
23. He Y, Yao DQ, Gu YX, Lin ZJ, Zheng CD, Fan HF (2007) OASIS and molecular-replacement model completion. Acta Crystallogr D: Biol Crystallogr 63:793-799 (Pubitemid 46975669)
24. Emsley P, Lohkamp B, Scott WG, Cowtan K (2010) Features and development of Coot. Acta Crystallogr D: Biol Crystallogr 66:486-501
25. Murshudov GN, Vagin AA, Dodson EJ (1997) Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D: Biol Crystallogr 53:240-255 (Pubitemid 27235885)
26. Terwilliger TC, Grosse-Kunstleve RW, Afonine PV, Moriarty NW, Zwart PH, Hung LW, Read RJ, Adams PD (2008) Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard. Acta Crystallogr D: Biol Crystallogr 64:61-69 (Pubitemid 350308678)
27. Chen VB, Arendall WB 3rd, Headd JJ, Keedy DA, Immormino RM, Kapral GJ, Murray LW, Richardson JS, Richardson DC (2010) MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D: Biol Crystallogr 66:12-21
28. Du W, Wang S, Sun Z, Yu W (2006) Construction of a fully synthetic human phage display antibody library. Bull Acad Mil Med Sci 30(319-322):328 [in Chinese]
29. Jaks E, Gavutis M, Uze G, Martal J, Piehler J (2007) Differential receptor subunit affinities of type I interferons govern differential signal activation. J Mol Biol 366:525-539 (Pubitemid 46136210)
30. Lawrence MC, Colman PM (1993) Shape complementarity at protein/protein interfaces. J Mol Biol 234:946-950 (Pubitemid 24027225)
31. Quadt-Akabayov SR, Chill JH, Levy R, Kessler N, Anglister J (2006) Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex. Protein Sci 15:2656-2668 (Pubitemid 44771702)
32. Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, Lee C, Yarden G, Vleck SE, Glenn JS et al (2011) Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell 146:621-632
33. Yao Y, Richman L, Higgs BW, Morehouse CA, de los Reyes M, Brohawn P, Zhang J, White B, Coyle AJ, Kiener PA et al (2009) Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferonalpha monoclonal antibody in systemic lupus erythematosus. Arthritis Rheum 60:1785-1796
34. Nolte KU, Gunther G, vonWussow P (1996) Epitopes recognized by neutralizing therapy-induced human anti-interferon-alpha antibodies are localized within the N-terminal functional domain of recombinant interferon-alpha 2. Eur J Immunol 26:2155-2159 (Pubitemid 26297516)