Multiple natural substitutions in avian influenza A virus PB2 facilitate efficient replication in human cells

Journal of Virology

Volumn 90, Issue 13, 2016, Pages 5928-5938

  Mänz, Benjamin ^a   de Graaf, Miranda ^a   Mögling, Ramona ^a   Richard, Mathilde ^a   Bestebroer, Theo M ^a   Rimmelzwaan, Guus F ^a   Fouchier, Ron A M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PB2 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; PB2 PROTEIN, INFLUENZAVIRUS A; RNA DIRECTED RNA POLYMERASE; VIRAL PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; AVIAN INFLUENZA VIRUS; BIOINFORMATICS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLUENZA A VIRUS (H5N1); INFLUENZA A VIRUS (H7N9); NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; VIRUS REPLICATION; ADAPTATION; ANIMAL; AVIAN INFLUENZA; BIOLOGY; BIRD; CELL LINE; CHEMISTRY; ENZYMOLOGY; GENETICS; HEK293 CELL LINE; HOST RANGE; INFLUENZA; INFLUENZA A VIRUS (H1N1); METABOLISM; PHYSIOLOGY; VIROLOGY;

ADAPTATION, PHYSIOLOGICAL; AMINO ACID SUBSTITUTION; ANIMALS; BIRDS; CELL LINE; COMPUTATIONAL BIOLOGY; HEK293 CELLS; HOST SPECIFICITY; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA A VIRUS, H7N9 SUBTYPE; INFLUENZA IN BIRDS; INFLUENZA, HUMAN; PHYLOGENY; RNA REPLICASE; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84975260047     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00130-16     Document Type: Article

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