Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus

Nature Communications

Volumn 6, Issue , 2015, Pages

  Taft, Andrew S ^a   Ozawa, Makoto ^b   Fitch, Adam ^c   Depasse, Jay V ^c   Halfmann, Peter J ^a   Hill Batorski, Lindsay ^a   Hatta, Masato ^a   Friedrich, Thomas C ^d,e   Lopes, Tiago J S ^a,h   Maher, Eileen A ^a   Ghedin, Elodie ^c,f   Macken, Catherine A ^g   Neumann, Gabriele ^a   Kawaoka, Yoshihiro ^a,h,i  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WISCONSIN   (United States)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f NEW YORK UNIVERSITY   (United States)

^g UNIVERSITY OF AUCKLAND   (New Zealand)

^h UNIVERSITY OF TOKYO   (Japan)

ⁱ Infection Induced Host Responses Project Exploratory Research for Advanced Technology   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; HEMAGGLUTININ; MESSENGER RNA; VIRUS ENZYME; VIRUS PROTEIN; VIRAL PROTEIN;

ENZYME ACTIVITY; GENE EXPRESSION; GERM CELL; INFECTIVITY; MAMMAL; MUTATION; VIRULENCE; VIRUS;

A549 CELL LINE; ADAPTATION; AMINO ACID ANALYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVIAN INFLUENZA; AVIAN INFLUENZA VIRUS; CONTROLLED STUDY; DNA LIBRARY; ENZYME ACTIVITY; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLUENZA VIRUS A H5N1; MOUSE; NONHUMAN; OPEN READING FRAME; PREVALENCE; PROTEIN EXPRESSION; RNA SYNTHESIS; SEQUENCE ANALYSIS; STRUCTURAL GENE; VIRUS GENE; VIRUS IDENTIFICATION; VIRUS MUTANT; VIRUS MUTATION; VIRUS REPLICATION; VIRUS TITRATION; VIRUS VIRULENCE; ANIMAL; BAGG ALBINO MOUSE; DOG; GENETICS; HIGH THROUGHPUT SEQUENCING; INFLUENZA A VIRUS (H5N1); MDCK CELL LINE; MUTATION; PATHOGENICITY; REPORTER GENE;

AVES; AVIAN INFLUENZA VIRUS; MAMMALIA; MUS; ORTHOMYXOVIRIDAE;

ADAPTATION, BIOLOGICAL; ANIMALS; DOGS; FEMALE; GENES, REPORTER; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HIGH-THROUGHPUT SCREENING ASSAYS; INFLUENZA A VIRUS, H5N1 SUBTYPE; MADIN DARBY CANINE KIDNEY CELLS; MICE, INBRED BALB C; MUTATION; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84935878342     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8491     Document Type: Article

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