Imatinib triggers phagolysosome acidification and antimicrobial activity against mycobacterium bovis bacille Calmette-Guérin in glucocorticoid-treated human macrophages

Journal of Immunology

Volumn 197, Issue 1, 2016, Pages 222-232

  Steiger, Julia ^a   Stephan, Alexander ^a   Inkeles, Megan S ^b   Realegeno, Susan ^b   Bruns, Heiko ^c   Kröll, Philipp ^a   De Castro Kroner, Juliana ^a   Sommer, Andrea ^a   Batinica, Marina ^a   Pitzler, Lena ^a   Kalscheuer, Rainer ^d   Hartmann, Pia ^a   Plum, Georg ^a   Stenger, Steffen ^e   Pellegrini, Matteo ^b   Brachvogel, Bent ^a   Modlin, Robert L ^b,f   Fabri, Mario ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e UNIVERSITY HOSPITAL ULM   (Germany)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN; GAMMA INTERFERON; GLUCOCORTICOID; IMATINIB; PROTEIN TCIRG1; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; TCIRG1 PROTEIN, HUMAN; TUBERCULOSTATIC AGENT;

ACIDIFICATION; ARTICLE; AUTOPHAGY; CELL VACUOLE; CONTROLLED STUDY; CYTOLYSIS; GENE EXPRESSION PROFILING; HOST RESISTANCE; HUMAN; HUMAN CELL; LYSOSOME; MACROPHAGE; MYCOBACTERIUM BOVIS BCG; NONHUMAN; PHAGOLYSOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; UPREGULATION; CELL CULTURE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; MYCOBACTERIUM BOVIS; PH; PHAGOSOME; PHYSIOLOGY; TUBERCULOSIS;

ANTI-INFLAMMATORY AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; ANTITUBERCULAR AGENTS; AUTOPHAGY; CELLS, CULTURED; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; HYDROGEN-ION CONCENTRATION; IMATINIB MESYLATE; IMMUNITY, INNATE; INTERFERON-GAMMA; MACROPHAGES; MYCOBACTERIUM BOVIS; PHAGOSOMES; TUBERCULOSIS; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84975230192     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1502407     Document Type: Article

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