-
1
-
-
84940465028
-
-
World Health Organization. Global tuberculosis report. WHO report 2014. Available at
-
World Health Organization. Global tuberculosis report. WHO report 2014. Available at: http://apps.who.int/iris/bitstream/10665/137094/1/9789241564809-eng.pdf?ua=1.
-
-
-
-
2
-
-
0020068326
-
Epidemiology of tuberculosis
-
G.W. Comstock Epidemiology of tuberculosis Am Rev Respir Dis 125 1982 8 15
-
(1982)
Am Rev Respir Dis
, vol.125
, pp. 8-15
-
-
Comstock, G.W.1
-
4
-
-
0035432383
-
Mycobacterium tuberculosis: Here today, and here tomorrow
-
D.G. Russell Mycobacterium tuberculosis: here today, and here tomorrow Nat Rev Mol Cell Biol 2 2001 569 577
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 569-577
-
-
Russell, D.G.1
-
5
-
-
38049178475
-
On the killing of mycobacteria by macrophages
-
L. Jordao, C.K. Bleck, L. Mayorga, G. Griffiths, and E. Anes On the killing of mycobacteria by macrophages Cell Microbiol 10 2008 529 548
-
(2008)
Cell Microbiol
, vol.10
, pp. 529-548
-
-
Jordao, L.1
Bleck, C.K.2
Mayorga, L.3
Griffiths, G.4
Anes, E.5
-
6
-
-
0028909199
-
Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited
-
D.L. Clemens, and M.A. Horwitz Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited J Exp Med 181 1995 257 270
-
(1995)
J Exp Med
, vol.181
, pp. 257-270
-
-
Clemens, D.L.1
Horwitz, M.A.2
-
7
-
-
34548591486
-
Mycobacterium tuberculosis and the environment within the phagosome
-
K. Rohde, R.M. Yates, G.E. Purdy, and D.G. Russell Mycobacterium tuberculosis and the environment within the phagosome Immunol Rev 219 2007 37 54
-
(2007)
Immunol Rev
, vol.219
, pp. 37-54
-
-
Rohde, K.1
Yates, R.M.2
Purdy, G.E.3
Russell, D.G.4
-
8
-
-
67649414120
-
The many niches and strategies used by pathogenic mycobacteria for survival within host macrophages
-
C. de Chastellier The many niches and strategies used by pathogenic mycobacteria for survival within host macrophages Immunobiology 214 2009 526 542
-
(2009)
Immunobiology
, vol.214
, pp. 526-542
-
-
De Chastellier, C.1
-
9
-
-
10944253145
-
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
-
M.G. Gutierrez, S.S. Master, S.B. Singh, G.A. Taylor, M.I. Colombo, and V. Deretic Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages Cell 119 6 2004 753 766
-
(2004)
Cell
, vol.119
, Issue.6
, pp. 753-766
-
-
Gutierrez, M.G.1
Master, S.S.2
Singh, S.B.3
Taylor, G.A.4
Colombo, M.I.5
Deretic, V.6
-
10
-
-
84869217908
-
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation
-
E.F. Castillo, A. Dekonenko, J. Arko-Mensah, M.A. Mandell, N. Dupont, S. Jiang, M. Delgado-Vargas, G.S. Timmins, D. Bhattacharya, H. Yang, J. Hutt, C.R. Lyons, K.M. Dobos, and V. Deretic Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation Proc Natl Acad Sci USA 109 46 2012 E3168 E3176
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.46
, pp. E3168-E3176
-
-
Castillo, E.F.1
Dekonenko, A.2
Arko-Mensah, J.3
Mandell, M.A.4
Dupont, N.5
Jiang, S.6
Delgado-Vargas, M.7
Timmins, G.S.8
Bhattacharya, D.9
Yang, H.10
Hutt, J.11
Lyons, C.R.12
Dobos, K.M.13
Deretic, V.14
-
12
-
-
60149098494
-
Beta-androstenes and resistance to viral and bacterial infections
-
R.M. Loria Beta-androstenes and resistance to viral and bacterial infections Neuroimmunomodulation 16 2 2009 88 95
-
(2009)
Neuroimmunomodulation
, vol.16
, Issue.2
, pp. 88-95
-
-
Loria, R.M.1
-
13
-
-
33845971318
-
Endocrine and cytokine responses in humans with pulmonary tuberculosis
-
A. del Rey, C.V. Mahuad, V.V. Bozza, C. Bogue, M.A. Farroni, M.L. Bay, O.A. Bottasso, and H.O. Besedovsky Endocrine and cytokine responses in humans with pulmonary tuberculosis Brain Behav Immun 21 2007 171 179
-
(2007)
Brain Behav Immun
, vol.21
, pp. 171-179
-
-
Del Rey, A.1
Mahuad, C.V.2
Bozza, V.V.3
Bogue, C.4
Farroni, M.A.5
Bay, M.L.6
Bottasso, O.A.7
Besedovsky, H.O.8
-
14
-
-
84873290175
-
Adverse neuro-immune-endocrine interactions in patients with active tuberculosis
-
O. Bottasso, M.L. Bay, H. Besedovsky, and A. Del Rey Adverse neuro-immune-endocrine interactions in patients with active tuberculosis Mol Cell Neurosci 53 2013 77 85
-
(2013)
Mol Cell Neurosci
, vol.53
, pp. 77-85
-
-
Bottasso, O.1
Bay, M.L.2
Besedovsky, H.3
Del Rey, A.4
-
15
-
-
84864134020
-
Changes in the immune-endocrine response in patients with pulmonary tuberculosis undergoing specific treatment
-
B. Bongiovanni, A. Díaz, L. D'Attilio, N. Santucci, G. Dídoli, J.L. Nannini, W. Gardeñez, C. Bogue, H. Besedovsky, A. del Rey, O. Bottasso, and M.L. Bay Changes in the immune-endocrine response in patients with pulmonary tuberculosis undergoing specific treatment Ann N Y AcadSci 1262 1 2012 10 15
-
(2012)
Ann N y AcadSci
, vol.1262
, Issue.1
, pp. 10-15
-
-
Bongiovanni, B.1
Díaz, A.2
D'Attilio, L.3
Santucci, N.4
Dídoli, G.5
Nannini, J.L.6
Gardeñez, W.7
Bogue, C.8
Besedovsky, H.9
Del Rey, A.10
Bottasso, O.11
Bay, M.L.12
-
16
-
-
44649128524
-
Mycobacterium tuberculosis and the macrophage: Maintaining a balance
-
J. Pieters Mycobacterium tuberculosis and the macrophage: maintaining a balance Cell Host Microbe 3 2008 399 407
-
(2008)
Cell Host Microbe
, vol.3
, pp. 399-407
-
-
Pieters, J.1
-
17
-
-
0030063866
-
Immunopathology of tuberculosis: Roles of macrophages and monocytes
-
M.J. Fenton, and M.W. Vermeulen Immunopathology of tuberculosis: roles of macrophages and monocytes Infect Immun 64 1996 683 690
-
(1996)
Infect Immun
, vol.64
, pp. 683-690
-
-
Fenton, M.J.1
Vermeulen, M.W.2
-
18
-
-
31944432932
-
Mycobacterium tuberculosis growth control by lung macrophages and CD8 cells from patient contacts
-
C. Carranza, E. Juárez, M. Torres, J. Ellner, and E. Sada Mycobacterium tuberculosis growth control by lung macrophages and CD8 cells from patient contacts Am J Respir Crit Care Med 173 2006 238 245
-
(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 238-245
-
-
Carranza, C.1
Juárez, E.2
Torres, M.3
Ellner, J.4
Sada, E.5
-
19
-
-
0018871095
-
Establishment and characterization of a human acute monocytic leukemia cell line (THP-1)
-
S. Tuchiya, M. Yamabe, Y. Yamaguchi, Y. Kobayashi, T. Konno, and K. Tada Establishment and characterization of a human acute monocytic leukemia cell line (THP-1) Int J Cancer 26 1980 171 176
-
(1980)
Int J Cancer
, vol.26
, pp. 171-176
-
-
Tuchiya, S.1
Yamabe, M.2
Yamaguchi, Y.3
Kobayashi, Y.4
Konno, T.5
Tada, K.6
-
20
-
-
10844277285
-
Cortisol and dehydroepiandrosterone affect the response of peripheral blood mononuclear cells to mycobacterial antigens during tuberculosis
-
C. Mahuad, M.L. Bay, M.A. Farroni, V. Bozza, A. Del Rey, H. Besedovsky, and O.A. Bottasso Cortisol and dehydroepiandrosterone affect the response of peripheral blood mononuclear cells to mycobacterial antigens during tuberculosis Scand J Immunol 60 2004 639 646
-
(2004)
Scand J Immunol
, vol.60
, pp. 639-646
-
-
Mahuad, C.1
Bay, M.L.2
Farroni, M.A.3
Bozza, V.4
Del Rey, A.5
Besedovsky, H.6
Bottasso, O.A.7
-
21
-
-
79551690196
-
mRNA expression of alpha and beta isoforms of glucocorticoid receptor in peripheral blood mononuclear cells of patients with TB and its relation with components of the immunoendocrine response
-
L. D'Attilio, E. Trini, B. Bongiovanni, G. Dídoli, W. Gardeñez, L. Nannini, A. Giri, A. Bottasso, and M.L. Bay mRNA expression of alpha and beta isoforms of glucocorticoid receptor in peripheral blood mononuclear cells of patients with TB and its relation with components of the immunoendocrine response Brain Behav Immun 25 2011 461 467
-
(2011)
Brain Behav Immun
, vol.25
, pp. 461-467
-
-
D'Attilio, L.1
Trini, E.2
Bongiovanni, B.3
Dídoli, G.4
Gardeñez, W.5
Nannini, L.6
Giri, A.7
Bottasso, A.8
Bay, M.L.9
-
22
-
-
23344443341
-
Human {beta}-defensin 2 is expressed and associated with Mycobacterium tuberculosis during infection of human alveolar epithelial cells
-
B. Rivas-Santiago, S.K. Schwander, C. Sarabia, G. Diamond, M.E. Klein-Patel, R. Hernandez-Pando, J.J. Ellner, and E. Sada Human {beta}-defensin 2 is expressed and associated with Mycobacterium tuberculosis during infection of human alveolar epithelial cells Infect Immun 73 2005 4505 4511
-
(2005)
Infect Immun
, vol.73
, pp. 4505-4511
-
-
Rivas-Santiago, B.1
Schwander, S.K.2
Sarabia, C.3
Diamond, G.4
Klein-Patel, M.E.5
Hernandez-Pando, R.6
Ellner, J.J.7
Sada, E.8
-
23
-
-
15244340430
-
Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis
-
I. Vergne, J. Chua, H.H. Lee, M. Lucas, J. Belisle, and V. Deretic Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis Proc Natl Acad Sci USA 102 2005 4033 4038
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 4033-4038
-
-
Vergne, I.1
Chua, J.2
Lee, H.H.3
Lucas, M.4
Belisle, J.5
Deretic, V.6
-
24
-
-
67651171188
-
Mycobacterium evades macrophage defenses by inhibiting plasma membrane repair
-
M. Divangahi, M. Chen, H. Gan, D. Desjardins, T.T. Hickman, D.M. Lee, S. Fortune, S.M. Behar, and H.G. Remold Mycobacterium evades macrophage defenses by inhibiting plasma membrane repair Nat Immunol 10 2009 899 906
-
(2009)
Nat Immunol
, vol.10
, pp. 899-906
-
-
Divangahi, M.1
Chen, M.2
Gan, H.3
Desjardins, D.4
Hickman, T.T.5
Lee, D.M.6
Fortune, S.7
Behar, S.M.8
Remold, H.G.9
-
25
-
-
0035975717
-
The process of aging changesthe interplay of the immune, endocrine and nervous systems
-
R.H. Straub, M. Cutolo, B. Zietz, and J. Scholmerich The process of aging changesthe interplay of the immune, endocrine and nervous systems Mech Ageing Dev 122 14 2001 1591 1611
-
(2001)
Mech Ageing Dev
, vol.122
, Issue.14
, pp. 1591-1611
-
-
Straub, R.H.1
Cutolo, M.2
Zietz, B.3
Scholmerich, J.4
-
26
-
-
77955393101
-
Cortisol, DHEAsulphate, their ratio, and all-cause and cause-specific mortality in theVietnam experience Study
-
A.C. Phillips, D. Carroll, C.R. Gale, J.M. Lord, W. Arlt, and G.D. Batty Cortisol, DHEAsulphate, their ratio, and all-cause and cause-specific mortality in theVietnam experience Study Eur J Endocrinol 163 2 2010 285 292
-
(2010)
Eur J Endocrinol
, vol.163
, Issue.2
, pp. 285-292
-
-
Phillips, A.C.1
Carroll, D.2
Gale, C.R.3
Lord, J.M.4
Arlt, W.5
Batty, G.D.6
-
28
-
-
37048998942
-
Impaired immune responses in tuberculosis patients are related to weight loss that coexists with an immunoendocrineimbalance
-
C. Mahuad, V. Bozza, S.M. Pezzotto, M.L. Bay, H. Besedovsky, A. del Rey, and O. Bottasso Impaired immune responses in tuberculosis patients are related to weight loss that coexists with an immunoendocrineimbalance Neuroimmunomodulation 14 3-4 2007 193 199
-
(2007)
Neuroimmunomodulation
, vol.14
, Issue.3-4
, pp. 193-199
-
-
Mahuad, C.1
Bozza, V.2
Pezzotto, S.M.3
Bay, M.L.4
Besedovsky, H.5
Del Rey, A.6
Bottasso, O.7
-
29
-
-
84864148823
-
TGF-β neutralization abrogates the inhibited DHEA production mediated by factors released from M. Tuberculosis-stimulated PBMC
-
L. D'Attilio, V.V. Bozza, N. Santucci, B. Bongiovanni, G. Dídoli, S. Radcliffe, H. Besedovsky, A. del Rey, O. Bottasso, and M.L. Bay TGF-β neutralization abrogates the inhibited DHEA production mediated by factors released from M. tuberculosis-stimulated PBMC Ann N Y Acad Sci 1262 2012 1 9
-
(2012)
Ann N y Acad Sci
, vol.1262
, pp. 1-9
-
-
D'Attilio, L.1
Bozza, V.V.2
Santucci, N.3
Bongiovanni, B.4
Dídoli, G.5
Radcliffe, S.6
Besedovsky, H.7
Del Rey, A.8
Bottasso, O.9
Bay, M.L.10
-
30
-
-
0031752347
-
The effects of androstenediol and dehydroepiandrosterone on the course and cytokine profile of tuberculosis in BALB/c mice
-
R. Hernandez-Pando, M. De La Luz Streber, H. Orozco, K. Arriaga, L. Pavon, S.A. Al-Nakhli, and G.A. Rook The effects of androstenediol and dehydroepiandrosterone on the course and cytokine profile of tuberculosis in BALB/c mice Immunology 95 2 1998 234 241
-
(1998)
Immunology
, vol.95
, Issue.2
, pp. 234-241
-
-
Hernandez-Pando, R.1
De La Luz Streber, M.2
Orozco, H.3
Arriaga, K.4
Pavon, L.5
Al-Nakhli, S.A.6
Rook, G.A.7
-
31
-
-
0032037616
-
Macrophage receptors for Mycobacterium tuberculosis
-
J.D. Ernst Macrophage receptors for Mycobacterium tuberculosis Infec Immun 66 1998 1277 1281
-
(1998)
Infec Immun
, vol.66
, pp. 1277-1281
-
-
Ernst, J.D.1
-
32
-
-
23944488210
-
Absence of complement receptor 3 results in reduced binding and ingestion of Mycobacterium tuberculosis but has no significant effect on the induction of reactive oxygen and nitrogen intermediates or on the survival of the bacteria in resident and interferon-gamma activated macrophages
-
A.W. Rooyakkers, and R.W. Stokes Absence of complement receptor 3 results in reduced binding and ingestion of Mycobacterium tuberculosis but has no significant effect on the induction of reactive oxygen and nitrogen intermediates or on the survival of the bacteria in resident and interferon-gamma activated macrophages Microb Pathog 39 2005 57 67
-
(2005)
Microb Pathog
, vol.39
, pp. 57-67
-
-
Rooyakkers, A.W.1
Stokes, R.W.2
-
33
-
-
84860495384
-
The role of Mycobacterium tuberculosis Rv3166cprotein-derived high-activity binding peptidesin inhibiting invasion of human cell lines
-
M. Ocampo, D. Aristizábal-Ramírez, D.M. Rodríguez, M. Muñoz, H. Curtidor, M. Vanegas, M.A. Patarroyo, and M.E. Patarroyo The role of Mycobacterium tuberculosis Rv3166cprotein-derived high-activity binding peptidesin inhibiting invasion of human cell lines Protein Eng Des Sel 25 5 2012 235 242
-
(2012)
Protein Eng des Sel
, vol.25
, Issue.5
, pp. 235-242
-
-
Ocampo, M.1
Aristizábal-Ramírez, D.2
Rodríguez, D.M.3
Muñoz, M.4
Curtidor, H.5
Vanegas, M.6
Patarroyo, M.A.7
Patarroyo, M.E.8
-
34
-
-
0031133280
-
Programmed celldeath of Mycobacterium aviumserovar 4-infected human macrophages preventsmycobacteria from spreading and induces mycobacterial growth inhibition byfreshly added, uninfected macrophages
-
C. Fratazzi, R.D. Arbeit, C. Carini, and H.G. Remold Programmed celldeath of Mycobacterium aviumserovar 4-infected human macrophages preventsmycobacteria from spreading and induces mycobacterial growth inhibition byfreshly added, uninfected macrophages J Immunol 158 1997 4320 4327
-
(1997)
J Immunol
, vol.158
, pp. 4320-4327
-
-
Fratazzi, C.1
Arbeit, R.D.2
Carini, C.3
Remold, H.G.4
-
35
-
-
0042328107
-
Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells
-
L. Danelishvili, J. McGarvey, Y.J. Li, and L.E. Bermudez Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells Cell Microbiol 5 2003 649 660
-
(2003)
Cell Microbiol
, vol.5
, pp. 649-660
-
-
Danelishvili, L.1
McGarvey, J.2
Li, Y.J.3
Bermudez, L.E.4
-
36
-
-
2542476850
-
Differential induction of apoptosis and necrosis in monocytes from patients with tuberculosis and healthy control subjects
-
D.P. Gil, L.G. León, L.I. Correa, J.R. Maya, S.C. París, L.F. García, and M. Rojas Differential induction of apoptosis and necrosis in monocytes from patients with tuberculosis and healthy control subjects J Infect Dis 189 2004 2120 2128
-
(2004)
J Infect Dis
, vol.189
, pp. 2120-2128
-
-
Gil, D.P.1
León, L.G.2
Correa, L.I.3
Maya, J.R.4
París, S.C.5
García, L.F.6
Rojas, M.7
-
37
-
-
25444486695
-
Survival of virulent Mycobacterium tuberculosis involves preventing apoptosis induced by Bcl-2 upregulation and release resulting from necrosis in J774 macrophages
-
J. Zhang, R. Jiang, H. Takayama, and Y. Tanaka Survival of virulent Mycobacterium tuberculosis involves preventing apoptosis induced by Bcl-2 upregulation and release resulting from necrosis in J774 macrophages Microbiol Immunol 2005 49 2005 845 852
-
(2005)
Microbiol Immunol
, vol.2005
, Issue.49
, pp. 845-852
-
-
Zhang, J.1
Jiang, R.2
Takayama, H.3
Tanaka, Y.4
-
38
-
-
84899525624
-
A novel mechanism underlying the basic defensive response of macrophages against Mycobacterium infection
-
T. Iyoda, M. Takada, Y. Fukatsu, S. Kumokoshi, T. Fujisawa, T. Shimada, N. Shimokawa, T. Matsunaga, K. Makino, N. Doi, H. Terada, and F. Fukai A novel mechanism underlying the basic defensive response of macrophages against Mycobacterium infection J Immunol 192 9 2014 4254 4262
-
(2014)
J Immunol
, vol.192
, Issue.9
, pp. 4254-4262
-
-
Iyoda, T.1
Takada, M.2
Fukatsu, Y.3
Kumokoshi, S.4
Fujisawa, T.5
Shimada, T.6
Shimokawa, N.7
Matsunaga, T.8
Makino, K.9
Doi, N.10
Terada, H.11
Fukai, F.12
-
39
-
-
84874097064
-
Plasma cells require autophagy for sustainable immunoglobulin production
-
N. Pengo, M. Scolari, L. Oliva, E. Milan, F. Mainoldi, A. Raimondi, C. Fagioli, A. Merlini, E. Mariani, E. Pasqualetto, U. Orfanelli, M. Ponzoni, R. Sitia, S. Casola, and S. Cenci Plasma cells require autophagy for sustainable immunoglobulin production Nat Immunol 14 3 2013 298 305
-
(2013)
Nat Immunol
, vol.14
, Issue.3
, pp. 298-305
-
-
Pengo, N.1
Scolari, M.2
Oliva, L.3
Milan, E.4
Mainoldi, F.5
Raimondi, A.6
Fagioli, C.7
Merlini, A.8
Mariani, E.9
Pasqualetto, E.10
Orfanelli, U.11
Ponzoni, M.12
Sitia, R.13
Casola, S.14
Cenci, S.15
-
40
-
-
79951910694
-
Autophagy in immunity and cell-autonomous defense against intracellular microbes
-
V. Deretic Autophagy in immunity and cell-autonomous defense against intracellular microbes Immunol Rev 240 1 2011 92 104
-
(2011)
Immunol Rev
, vol.240
, Issue.1
, pp. 92-104
-
-
Deretic, V.1
-
41
-
-
78751672975
-
Autophagy in immunity and inflammation
-
B. Levine, N. Mizushima, and H.W. Virgin Autophagy in immunity and inflammation Nature 469 7330 2011 323 335
-
(2011)
Nature
, vol.469
, Issue.7330
, pp. 323-335
-
-
Levine, B.1
Mizushima, N.2
Virgin, H.W.3
-
42
-
-
84886797274
-
Autophagy in infection, inflammation and immunity
-
V. Deretic, T. Saitoh, and S. Akira Autophagy in infection, inflammation and immunity Nat Rev Immunol 13 2013 722 737
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 722-737
-
-
Deretic, V.1
Saitoh, T.2
Akira, S.3
-
43
-
-
84881635380
-
The impact of macroautophagy on CD8(+) T-cell-mediated antiviral immunity
-
B.P. Perot, M.A. Ingersoll, and M.L. Albert The impact of macroautophagy on CD8(+) T-cell-mediated antiviral immunity Immunol Rev 255 2013 40 56
-
(2013)
Immunol Rev
, vol.255
, pp. 40-56
-
-
Perot, B.P.1
Ingersoll, M.A.2
Albert, M.L.3
-
44
-
-
84865299726
-
PAMPs and DAMPs: Signal 0s that spur autophagy and immunity
-
D. Tang, R. Kang, C.B. Coyne, H.J. Zeh, and M.T. Lotze PAMPs and DAMPs: signal 0s that spur autophagy and immunity Immunol Rev 249 2012 158 175
-
(2012)
Immunol Rev
, vol.249
, pp. 158-175
-
-
Tang, D.1
Kang, R.2
Coyne, C.B.3
Zeh, H.J.4
Lotze, M.T.5
-
45
-
-
84923917639
-
Autophagy in tuberculosis
-
V. Deretic Autophagy in tuberculosis Cold Spring Harb Perspect Med 4 11 2014 10.1101/cshperspect.a018481
-
(2014)
Cold Spring Harb Perspect Med
, vol.4
, Issue.11
-
-
Deretic, V.1
|