Interventions for erythema nodosum leprosum. A Cochrane review

Leprosy Review

Volumn 80, Issue 4, 2009, Pages 355-372

  Van Veen, Natasja H J ^a   Lockwood, Diana N J ^b   Van Brakel, Wim H ^c   Ramirez Jr , J ^d   Richardus, Jan Hendrik ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c ROYAL TROPICAL INSTITUTE   (Netherlands)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANALGESIC AGENT; BETAMETHASONE; CHLOROQUINE; CHLORPROMAZINE; CLOFAZIMINE; CORTICOSTEROID; CORTICOTROPIN; DAPSONE; DIURETIC AGENT; GLUCOSE; INDOMETACIN; IRON; LEPROSTATIC AGENT; LEVAMISOLE; PARACETAMOL; PENTOXIFYLLINE; PHENOBARBITAL; PLACEBO; PREDNISOLONE; STEROID; STIBOPHEN; SULFONE; THALIDOMIDE;

ABDOMINAL PAIN; ACNE; ADD ON THERAPY; ADVERSE OUTCOME; ANEMIA; ANTIBIOTIC THERAPY; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONSTIPATION; CORTICOSTEROID THERAPY; CUSHING SYNDROME; CUSHINGOID SYNDROME; DERMATITIS; DIZZINESS; DROWSINESS; DRUG DOSE COMPARISON; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG MEGADOSE; DRUG SAFETY; DRUG WITHDRAWAL; DRY SKIN; EDEMA; ERYTHEMA NODOSUM LEPROSUM; FEVER; GASTROINTESTINAL SYMPTOM; HUMAN; INSOMNIA; INTESTINE OBSTRUCTION; LOW DRUG DOSE; META ANALYSIS; NAUSEA; REMISSION; REVIEW; SIDE EFFECT; SKIN PIGMENTATION; STRIA; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME;

ASPIRIN; CLOFAZIMINE; ERYTHEMA NODOSUM; HUMANS; LEPROSTATIC AGENTS; LEPROSY, LEPROMATOUS; PREDNISOLONE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; THALIDOMIDE; TREATMENT OUTCOME;

EID: 77649208306     PISSN: 03057518     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (24)

1. ILEP. How to recognise and manage leprosy reactions. The International Federation of Anti-Leprosy Associations (ILEP), London, 2002.
2. Lockwood DN. The management of erythema nodosum leprosum: current and future options. Lepr Rev, 1996; 67: 253-259.
3. Naafs B. Reactions: the body as battlefield II: immunopathology. Memisa Medisch, 2003; 69: 337-342.
4. Pocaterra L, Jain S, Reddy R et al. Clinical course of erythema nodosum leprosum: an 11-year cohort study in Hyderabad, India. Am J Trop Med Hyg, 2006; 74: 868-879.
5. Saunderson P, Gebre S, Byass P. ENL reactions in the multibacillary cases of the AMFES cohort in central Ethiopia: incidence and risk factors. Lepr Rev, 2000; 71: 318-324.
6. ILEP publication. The management of erythema nodosum leprosum. ILEP Technical Bulletin 1996.
7. World Health Organization. WHO Guidelines for the management of severe erythema nodosum leprosum (ENL) reactions.
8. Walker SL, Waters MF, Lockwood DN. The role of thalidomide in the management of erythema nodosum leprosum. Lepr Rev, 2007; 78: 197-215.
9. World Health Organization. WHO Expert Committee on Leprosy. World Health Organ Tech Rep Ser, 1998; 874: 1-43.
10. Smith WC, Nicholls P. Special workshop on repeated and late reactions. Int J Lepr Other Mycobact Dis, 2002; 70: 339-341.
11. van Brakel WH, Nicholls PG, Das L et al. The INFIR Cohort Study: investigating prediction, detection and pathogenesis of neuropathy and reactions in leprosy. Methods and baseline results of a cohort of multibacillary leprosy patients in north India. Lepr Rev, 2005; 76: 14-34.
12. Girdhar A, Chakma JK, Girdhar BK. Pulsed corticosteroid therapy in patients with chronic recurrent ENL: a pilot study. Indian J Lepr, 2002; 74: 233-236.
13. Pearson JM, Vedagiri M. Treatment of moderately severe erythema nodosum leprosum with thalidomide - a double-blind controlled trial. Lepr Rev, 1969; 40: 111-116.
14. Waters MF. An internally-controlled double blind trial of thalidomide in severe erythema nodosum leprosum. Lepr Rev, 1971; 42: 26-42.
15. Sheskin J, Convit J. Results of a double blind study of the influence of thalidomide on the lepra reaction. Int J Lepr Other Mycobact Dis, 1969; 37: 135-146.
16. Iyer CG, Languillon J, Ramanujam K et al. WHO co-ordinated short-term double-blind trial with thalidomide in the treatment of acute lepra reactions in male lepromatous patients. Bull World Health Organ, 1971; 45: 719-732.
17. Villahermosa LG, Fajardo TT, Jr, Abalos RM et al. A randomized, double-blind, double-dummy, controlled dose comparison of thalidomide for treatment of erythema nodosum leprosum. Am J Trop Med Hyg, 2005; 72: 518-526.
18. Sales AM, de Matos HJ, Nery JA et al. Double-blind trial of the efficacy of pentoxifylline vs thalidomide for the treatment of type II reaction in leprosy. Braz J Med Biol Res, 2007; 40: 243-248.
19. Helmy HS, Pearson JM, Waters MF. Treatment of moderately severe erythema nodosum leprosum with clofazimine - a controlled trial. Lepr Rev, 1971; 42: 167-177.
20. Iyer CG, Ramu G. An open trial with clofazimine in the management of recurrent lepra reaction using thalidomide as a control drug. Lepr India, 1976; 48(Suppl 4): 690-694.
21. Karat AB, Jeevaratnam A, Karat S, Rao PS. Double-blind controlled clinical trial of clofazimine in reactive phases of lepromatous leprosy. Br Med J, 1970; 1: 198-200.
22. Ing TH. Indomethacin in the treatment of erythema nodosum leprosum, in comparison with prednisolone. Singapore Med J, 1969; 10: 66-70.
23. Karat AB, Thomas G, Rao PS. Indomethacin in the management of erythema nodosum leprosum - a double-blind controlled trial. Lepr Rev, 1969; 40: 153-158.
24. Arora SK, Singh G, Sen PC. Effect of levamisole therapy on lepromin reaction in lepromatous leprosy cases. Int J Lepr Other Mycobact Dis, 1985; 53: 113-114.