메뉴 건너뛰기




Volumn 90, Issue 13, 2016, Pages 6097-6111

Characterization of human and murine T-cell immunoglobulin mucin domain 4 (TIM-4) IgV domain residues critical for Ebola virus entry

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; INTEGRIN; LIPOSOME; PHOSPHATIDYLSERINE; T CELL IMMUNOGLOBULIN MUCIN DOMAIN 4 PROTEIN; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; CELL SURFACE RECEPTOR; MEMBRANE PROTEIN; PHOSPHATIDYLSERINE RECEPTOR; TIM-4 PROTEIN, MOUSE; TIMD4 PROTEIN, HUMAN; VIRUS RECEPTOR;

EID: 84975217323     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00100-16     Document Type: Article
Times cited : (34)

References (59)
  • 1
    • 84940104261 scopus 로고    scopus 로고
    • Ebola virus disease: a review of its past and present
    • Murray MJ. 2015. Ebola virus disease: a review of its past and present. Anesth Analg 121:798-809. http://dx.doi.org/10.1213/ANE.0000000000000866.
    • (2015) Anesth Analg , vol.121 , pp. 798-809
    • Murray, M.J.1
  • 2
    • 84924806083 scopus 로고    scopus 로고
    • World Health Organization, Geneva, Switzerland. Accessed 9 September 2015
    • WHO. 2015. Ebola situation reports. World Health Organization, Geneva, Switzerland. http://apps.who.int/ebola/ebola-situation-reports. Accessed 9 September 2015.
    • (2015) Ebola situation reports
  • 3
    • 84917671407 scopus 로고    scopus 로고
    • Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses
    • Martines RB, Ng DL, Greer PW, Rollin PE, Zaki SR. 2015. Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses. J Pathol 235:153-174. http://dx.doi.org/10.1002/path.4456.
    • (2015) J Pathol , vol.235 , pp. 153-174
    • Martines, R.B.1    Ng, D.L.2    Greer, P.W.3    Rollin, P.E.4    Zaki, S.R.5
  • 4
    • 84975303912 scopus 로고    scopus 로고
    • Ebola virus entry into host cells: identifying therapeutic strategies
    • Rhein B, Maury W. 2015. Ebola virus entry into host cells: identifying therapeutic strategies. Curr Clin Microbiol Rep 2:115-124. http://dx.doi.org/10.1007/s40588-015-0021-3.
    • (2015) Curr Clin Microbiol Rep , vol.2 , pp. 115-124
    • Rhein, B.1    Maury, W.2
  • 5
    • 0036278649 scopus 로고    scopus 로고
    • C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    • Alvarez CP, Lasala F, Carrillo J, Muniz O, Corbi AL, Delgado R. 2002. C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. J Virol 76:6841-6844. http://dx.doi.org/10.1128/JVI.76.13.6841-6844.2002.
    • (2002) J Virol , vol.76 , pp. 6841-6844
    • Alvarez, C.P.1    Lasala, F.2    Carrillo, J.3    Muniz, O.4    Corbi, A.L.5    Delgado, R.6
  • 7
    • 84903364048 scopus 로고    scopus 로고
    • Comprehensive functional analysis of N-linked glycans on Ebola virus GP1
    • Lennemann NJ, Rhein BA, Ndungo E, Chandran K, Qiu X, Maury W. 2014. Comprehensive functional analysis of N-linked glycans on Ebola virus GP1. mBio 5:e00862-13. http://dx.doi.org/10.1128/mBio.00862-13.
    • (2014) mBio , vol.5
    • Lennemann, N.J.1    Rhein, B.A.2    Ndungo, E.3    Chandran, K.4    Qiu, X.5    Maury, W.6
  • 9
    • 78650045778 scopus 로고    scopus 로고
    • The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus
    • Hunt CL, Kolokoltsov AA, Davey RA, Maury W. 2011. The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus. J Virol 85:334-347. http://dx.doi.org/10.1128/JVI.01278-09.
    • (2011) J Virol , vol.85 , pp. 334-347
    • Hunt, C.L.1    Kolokoltsov, A.A.2    Davey, R.A.3    Maury, W.4
  • 10
    • 84896955320 scopus 로고    scopus 로고
    • Role of phosphatidylserine receptors in enveloped virus infection
    • Morizono K, Chen IS. 2014. Role of phosphatidylserine receptors in enveloped virus infection. J Virol 88:4275-4290. http://dx.doi.org/10.1128/JVI.03287-13.
    • (2014) J Virol , vol.88 , pp. 4275-4290
    • Morizono, K.1    Chen, I.S.2
  • 12
    • 84880594815 scopus 로고    scopus 로고
    • Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry
    • Moller-Tank S, Kondratowicz AS, Davey RA, Rennert PD, Maury W. 2013. Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry. J Virol 87:8327-8341. http://dx.doi.org/10.1128/JVI.01025-13.
    • (2013) J Virol , vol.87 , pp. 8327-8341
    • Moller-Tank, S.1    Kondratowicz, A.S.2    Davey, R.A.3    Rennert, P.D.4    Maury, W.5
  • 14
    • 84937250748 scopus 로고    scopus 로고
    • Viral apoptotic mimicry
    • Amara A, Mercer J. 2015. Viral apoptotic mimicry. Nat Rev Microbiol 13:461-469. http://dx.doi.org/10.1038/nrmicro3469.
    • (2015) Nat Rev Microbiol , vol.13 , pp. 461-469
    • Amara, A.1    Mercer, J.2
  • 18
    • 0032512724 scopus 로고    scopus 로고
    • Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury
    • Ichimura T, Bonventre JV, Bailly V, Wei H, Hession CA, Cate RL, Sanicola M. 1998. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem 273:4135-4142. http://dx.doi.org/10.1074/jbc.273.7.4135.
    • (1998) J Biol Chem , vol.273 , pp. 4135-4142
    • Ichimura, T.1    Bonventre, J.V.2    Bailly, V.3    Wei, H.4    Hession, C.A.5    Cate, R.L.6    Sanicola, M.7
  • 22
    • 36248944555 scopus 로고    scopus 로고
    • Identification of Tim4 as a phosphatidylserine receptor
    • Miyanishi M, Tada K, Koike M, Uchiyama Y, Kitamura T, Nagata S. 2007. Identification of Tim4 as a phosphatidylserine receptor. Nature 450: 435-439. http://dx.doi.org/10.1038/nature06307.
    • (2007) Nature , vol.450 , pp. 435-439
    • Miyanishi, M.1    Tada, K.2    Koike, M.3    Uchiyama, Y.4    Kitamura, T.5    Nagata, S.6
  • 23
    • 77951673268 scopus 로고    scopus 로고
    • TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
    • Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH. 2010. TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev 235:172-189. http://dx.doi.org/10.1111/j.0105-2896.2010.00903.x.
    • (2010) Immunol Rev , vol.235 , pp. 172-189
    • Freeman, G.J.1    Casasnovas, J.M.2    Umetsu, D.T.3    DeKruyff, R.H.4
  • 24
    • 84901363457 scopus 로고    scopus 로고
    • Characterizing functional domains for TIM-mediated enveloped virus entry
    • Moller-Tank S, Albritton LM, Rennert PD, Maury W. 2014. Characterizing functional domains for TIM-mediated enveloped virus entry. J Virol 88:6702-6713. http://dx.doi.org/10.1128/JVI.00300-14.
    • (2014) J Virol , vol.88 , pp. 6702-6713
    • Moller-Tank, S.1    Albritton, L.M.2    Rennert, P.D.3    Maury, W.4
  • 25
    • 37049039277 scopus 로고    scopus 로고
    • Structures of T cell immunoglobulin mucin protein 4 show a metal-ion-dependent ligand binding site where phosphatidylserine binds
    • Santiago C, Ballesteros A, Martínez-Muñoz L, Mellado M, Kaplan GG, Freeman GJ, Casasnovas JM. 2007. Structures of T cell immunoglobulin mucin protein 4 show a metal-ion-dependent ligand binding site where phosphatidylserine binds. Immunity 27:941-951. http://dx.doi.org/10.1016/j.immuni.2007.11.008.
    • (2007) Immunity , vol.27 , pp. 941-951
    • Santiago, C.1    Ballesteros, A.2    Martínez-Muñoz, L.3    Mellado, M.4    Kaplan, G.G.5    Freeman, G.J.6    Casasnovas, J.M.7
  • 26
    • 33947113954 scopus 로고    scopus 로고
    • Structures of T cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family
    • Santiago C, Ballesteros A, Tami C, Martinez-Munoz L, Kaplan GG, Casasnovas JM. 2007. Structures of T cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family. Immunity 26:299-310. http://dx.doi.org/10.1016/j.immuni.2007.01.014.
    • (2007) Immunity , vol.26 , pp. 299-310
    • Santiago, C.1    Ballesteros, A.2    Tami, C.3    Martinez-Munoz, L.4    Kaplan, G.G.5    Casasnovas, J.M.6
  • 28
    • 84945468130 scopus 로고    scopus 로고
    • TIM-1 acts a dual-attachment receptor for ebolavirus by interacting directly with viral GP and the PS on the viral envelope
    • Yuan S, Cao L, Ling H, Dang M, Sun Y, Zhang X, Chen Y, Zhang L, Su D, Wang X, Rao Z. 2015. TIM-1 acts a dual-attachment receptor for ebolavirus by interacting directly with viral GP and the PS on the viral envelope. Protein Cell 6:814-824. http://dx.doi.org/10.1007/s13238-015-0220-y.
    • (2015) Protein Cell , vol.6 , pp. 814-824
    • Yuan, S.1    Cao, L.2    Ling, H.3    Dang, M.4    Sun, Y.5    Zhang, X.6    Chen, Y.7    Zhang, L.8    Su, D.9    Wang, X.10    Rao, Z.11
  • 30
    • 60349123136 scopus 로고    scopus 로고
    • The phosphatidylserine receptor TIM-4 does not mediate direct signaling
    • Park D, Hochreiter-Hufford A, Ravichandran KS. 2009. The phosphatidylserine receptor TIM-4 does not mediate direct signaling. Curr Biol 19:346-351. http://dx.doi.org/10.1016/j.cub.2009.01.042.
    • (2009) Curr Biol , vol.19 , pp. 346-351
    • Park, D.1    Hochreiter-Hufford, A.2    Ravichandran, K.S.3
  • 33
    • 0033831191 scopus 로고    scopus 로고
    • Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury
    • Yang ZY, Duckers HJ, Sullivan NJ, Sanchez A, Nabel EG, Nabel GJ. 2000. Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury. Nat Med 6:886-889. http://dx.doi.org/10.1038/78645.
    • (2000) Nat Med , vol.6 , pp. 886-889
    • Yang, Z.Y.1    Duckers, H.J.2    Sullivan, N.J.3    Sanchez, A.4    Nabel, E.G.5    Nabel, G.J.6
  • 34
    • 0036893140 scopus 로고    scopus 로고
    • Covalent modifications of the Ebola virus glycoprotein
    • Jeffers SA, Sanders DA, Sanchez A. 2002. Covalent modifications of the Ebola virus glycoprotein. J Virol 76:12463-12472. http://dx.doi.org/10.1128/JVI.76.24.12463-12472.2002.
    • (2002) J Virol , vol.76 , pp. 12463-12472
    • Jeffers, S.A.1    Sanders, D.A.2    Sanchez, A.3
  • 35
    • 0038814328 scopus 로고    scopus 로고
    • Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independently of folate receptor alpha
    • Sinn PL, Hickey MA, Staber PD, Dylla DE, Jeffers SA, Davidson BL, Sanders DA, McCray PB, Jr. 2003. Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independently of folate receptor alpha. J Virol 77:5902-5910. http://dx.doi.org/10.1128/JVI.77.10.5902-5910.2003.
    • (2003) J Virol , vol.77 , pp. 5902-5910
    • Sinn, P.L.1    Hickey, M.A.2    Staber, P.D.3    Dylla, D.E.4    Jeffers, S.A.5    Davidson, B.L.6    Sanders, D.A.7    McCray, P.B.8
  • 36
    • 33745158157 scopus 로고
    • A simple method of estimating fifty percent endpoints
    • Reed LJ, Muench H. 1938. A simple method of estimating fifty percent endpoints. Am J Epidemiol 27:493-497.
    • (1938) Am J Epidemiol , vol.27 , pp. 493-497
    • Reed, L.J.1    Muench, H.2
  • 38
    • 84899817404 scopus 로고    scopus 로고
    • Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell carcinoma
    • Bedal KB, Grassel S, Oefner PJ, Reinders J, Reichert TE, Bauer R. 2014. Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell carcinoma. PLoS One 9:e86777. http://dx.doi.org/10.1371/journal.pone.0086777.
    • (2014) PLoS One , vol.9
    • Bedal, K.B.1    Grassel, S.2    Oefner, P.J.3    Reinders, J.4    Reichert, T.E.5    Bauer, R.6
  • 42
    • 84856789589 scopus 로고    scopus 로고
    • Two-step engulfment of apoptotic cells
    • Toda S, Hanayama R, Nagata S. 2012. Two-step engulfment of apoptotic cells. Mol Cell Biol 32:118-125. http://dx.doi.org/10.1128/MCB.05993-11.
    • (2012) Mol Cell Biol , vol.32 , pp. 118-125
    • Toda, S.1    Hanayama, R.2    Nagata, S.3
  • 43
    • 84896501141 scopus 로고    scopus 로고
    • Tim4-and MerTK-mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages
    • Nishi C, Toda S, Segawa K, Nagata S. 2014. Tim4-and MerTK-mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages. Mol Cell Biol 34:1512-1520. http://dx.doi.org/10.1128/MCB.01394-13.
    • (2014) Mol Cell Biol , vol.34 , pp. 1512-1520
    • Nishi, C.1    Toda, S.2    Segawa, K.3    Nagata, S.4
  • 44
    • 0034705005 scopus 로고    scopus 로고
    • Functional analyses of two cellular binding domains of bovine lactadherin
    • Andersen MH, Graversen H, Fedosov SN, Petersen TE, Rasmussen JT. 2000. Functional analyses of two cellular binding domains of bovine lactadherin. Biochemistry 39:6200-6206. http://dx.doi.org/10.1021/bi992221r.
    • (2000) Biochemistry , vol.39 , pp. 6200-6206
    • Andersen, M.H.1    Graversen, H.2    Fedosov, S.N.3    Petersen, T.E.4    Rasmussen, J.T.5
  • 45
    • 0037046580 scopus 로고    scopus 로고
    • Identification of a factor that links apoptotic cells to phagocytes
    • Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. 2002. Identification of a factor that links apoptotic cells to phagocytes. Nature 417:182-187. http://dx.doi.org/10.1038/417182a.
    • (2002) Nature , vol.417 , pp. 182-187
    • Hanayama, R.1    Tanaka, M.2    Miwa, K.3    Shinohara, A.4    Iwamatsu, A.5    Nagata, S.6
  • 46
    • 0001511468 scopus 로고
    • Variants of the cell recognition site of fibronectin that retain attachment-promoting activity
    • Pierschbacher MD, Ruoslahti E. 1984. Variants of the cell recognition site of fibronectin that retain attachment-promoting activity. Proc Natl Acad Sci U S A 81:5985-5988. http://dx.doi.org/10.1073/pnas.81.19.5985.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 5985-5988
    • Pierschbacher, M.D.1    Ruoslahti, E.2
  • 47
    • 0031730895 scopus 로고    scopus 로고
    • Fibronectin matrix assembly enhances adhesion-dependent cell growth
    • Sottile J, Hocking DC, Swiatek PJ. 1998. Fibronectin matrix assembly enhances adhesion-dependent cell growth. J Cell Sci 111(Pt 19):2933-2943.
    • (1998) J Cell Sci , vol.111 , pp. 2933-2943
    • Sottile, J.1    Hocking, D.C.2    Swiatek, P.J.3
  • 48
    • 33748300590 scopus 로고    scopus 로고
    • Phosphatidic acid-and phosphatidylserine-binding proteins
    • Stace CL, Ktistakis NT. 2006. Phosphatidic acid-and phosphatidylserine-binding proteins. Biochim Biophys Acta 1761:913-926. http://dx.doi.org/10.1016/j.bbalip.2006.03.006.
    • (2006) Biochim Biophys Acta , vol.1761 , pp. 913-926
    • Stace, C.L.1    Ktistakis, N.T.2
  • 49
    • 84912096164 scopus 로고    scopus 로고
    • The Ebola virus matrix protein VP40 selectively induces vesiculation from phosphatidylserine-enriched membranes
    • Soni SP, Stahelin RV. 2014. The Ebola virus matrix protein VP40 selectively induces vesiculation from phosphatidylserine-enriched membranes. J Biol Chem 289:33590-33597. http://dx.doi.org/10.1074/jbc.M114.586396.
    • (2014) J Biol Chem , vol.289 , pp. 33590-33597
    • Soni, S.P.1    Stahelin, R.V.2
  • 51
    • 0037065727 scopus 로고    scopus 로고
    • Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis
    • Pike LJ, Han X, Chung K-N, Gross RW. 2002. Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis. Biochemistry 41:2075-2088. http://dx.doi.org/10.1021/bi0156557.
    • (2002) Biochemistry , vol.41 , pp. 2075-2088
    • Pike, L.J.1    Han, X.2    Chung, K.-N.3    Gross, R.W.4
  • 52
    • 22844445240 scopus 로고    scopus 로고
    • Epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: a shotgun lipidomics study
    • Pike LJ, Han X, Gross RW. 2005. Epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: a shotgun lipidomics study. J Biol Chem 280:26796-26804. http://dx.doi.org/10.1074/jbc.M503805200.
    • (2005) J Biol Chem , vol.280 , pp. 26796-26804
    • Pike, L.J.1    Han, X.2    Gross, R.W.3
  • 53
    • 33947617935 scopus 로고    scopus 로고
    • Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals
    • Binné LL, Scott ML, Rennert PD. 2007. Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals. J Immunol 178:4342-4350. http://dx.doi.org/10.4049/jimmunol.178.7.4342.
    • (2007) J Immunol , vol.178 , pp. 4342-4350
    • Binné, L.L.1    Scott, M.L.2    Rennert, P.D.3
  • 55
    • 28044460035 scopus 로고    scopus 로고
    • T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation
    • de Souza AJ, Oriss TB, O'Malley KJ, Ray A, Kane LP. 2005. T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation. Proc Natl Acad Sci U S A 102: 17113-17118. http://dx.doi.org/10.1073/pnas.0508643102.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17113-17118
    • de Souza, A.J.1    Oriss, T.B.2    O'Malley, K.J.3    Ray, A.4    Kane, L.P.5
  • 56
    • 45549085191 scopus 로고    scopus 로고
    • T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase
    • de Souza AJ, Oak JS, Jordanhazy R, DeKruyff RH, Fruman DA, Kane LP. 2008. T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase. J Immunol 180:6518-6526. http://dx.doi.org/10.4049/jimmunol.180.10.6518.
    • (2008) J Immunol , vol.180 , pp. 6518-6526
    • de Souza, A.J.1    Oak, J.S.2    Jordanhazy, R.3    DeKruyff, R.H.4    Fruman, D.A.5    Kane, L.P.6
  • 57
    • 0025814801 scopus 로고
    • Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif
    • D'Souza SE, Ginsberg MH, Plow EF. 1991. Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif. Trends Biochem Sci 16:246-250. http://dx.doi.org/10.1016/0968-0004(91)90096-E.
    • (1991) Trends Biochem Sci , vol.16 , pp. 246-250
    • D'Souza, S.E.1    Ginsberg, M.H.2    Plow, E.F.3
  • 58
    • 84899693013 scopus 로고    scopus 로고
    • The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis
    • Flannagan RS, Canton J, Furuya W, Glogauer M, Grinstein S. 2014. The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis. Mol Biol Cell 25:1511-1522. http://dx.doi.org/10.1091/mbc.E13-04-0212.
    • (2014) Mol Biol Cell , vol.25 , pp. 1511-1522
    • Flannagan, R.S.1    Canton, J.2    Furuya, W.3    Glogauer, M.4    Grinstein, S.5
  • 59
    • 84947494362 scopus 로고    scopus 로고
    • TIM-4 promotes the growth of non-small-cell lung cancer in a RGDmotif-dependent manner
    • Zhang Q, Wang H, Wu X, Liu B, Liu W, Wang R, Liang X, Ma C, Gao L. 2015. TIM-4 promotes the growth of non-small-cell lung cancer in a RGDmotif-dependent manner. Br J Cancer 113:1484-1492. http://dx.doi.org/10.1038/bjc.2015.323.
    • (2015) Br J Cancer , vol.113 , pp. 1484-1492
    • Zhang, Q.1    Wang, H.2    Wu, X.3    Liu, B.4    Liu, W.5    Wang, R.6    Liang, X.7    Ma, C.8    Gao, L.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.