Exploring the structure of glutamate racemase from Mycobacterium tuberculosis as a template for anti-mycobacterial drug discovery

Biochemical Journal

Volumn 473, Issue 9, 2016, Pages 1267-1280

  Poen, Sinothai ^a   Nakatani, Yoshio ^a   Opel Reading, Helen K ^a   Lasse, Moritz ^b   Dobson, Renwick C J ^b,c   Krause, Kurt L ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF CANTERBURY   (New Zealand)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Analytical ultracentrifugation; Enzyme kinetics; Glutamate racemase; Monomer engineering; Mycobacterium tuberculosis; Thermofluor.

Indexed keywords

ANTIMYCOBACTERIAL AGENT; GLUTAMATE RACEMASE; RACEMASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; GLUTAMIC ACID; ISOMERASE;

ARTICLE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULTRACENTRIFUGATION; AMINO ACID SUBSTITUTION; CHEMISTRY; ENZYMOLOGY; GENETICS; MISSENSE MUTATION; PROTEIN DOMAIN;

AMINO ACID ISOMERASES; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; GLUTAMIC ACID; MUTATION, MISSENSE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN DOMAINS;

EID: 84975105974     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BCJ20160186     Document Type: Article

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