Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): Pyridodiazepine amines

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 930-936

  Geng, Bolin ^a   Basarab, Gregory ^a   Comita Prevoir, Janelle ^a   Gowravaram, Madhusudhan ^a   Hill, Pamela ^a   Kiely, Andrew ^a   Loch, James ^a   MacPherson, Lawrence ^a   Morningstar, Marshall ^a   Mullen, George ^a   Osimboni, Ekundayo ^a   Satz, Alexander ^a   Eyermann, Charles ^a   Lundqvist, Tomas ^b  

^a ASTRAZENECA   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Glutamate racemase; Helicobacter pylori; MurI inhibitor; Pyridodiazepine

Indexed keywords

ENZYME INHIBITOR; PYRIDODIAZEPINE AMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GENE; BINDING AFFINITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; HELICOBACTER PYLORI; HIGH THROUGHPUT SCREENING; MURL GENE; NONHUMAN; PLASMA PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINES; AMINO ACID ISOMERASES; ANIMALS; ANTI-INFECTIVE AGENTS; BINDING, COMPETITIVE; CHEMISTRY, PHARMACEUTICAL; DIMERIZATION; DRUG DESIGN; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

HELICOBACTER PYLORI;

EID: 58949099333     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.11.113     Document Type: Article

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