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Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4716-4722

Design of Helicobacter pylori glutamate racemase inhibitors as selective antibacterial agents: A novel pro-drug approach to increase exposure

(4) Basarab, Gregory S a Hill, Pamela J a Rastagar, Abdullah a Webborn, Peter J H a

a ASTRAZENECA (United Kingdom)

Author keywords

Glutamate racemase; MurI; Pro drug; Pyrazolopyrimidinedione

Indexed keywords

ANTIINFECTIVE AGENT; GLUTAMATE RACEMASE INHIBITOR; PYRAZOLOPYRIMIDINE DERIVATIVE; PYRAZOLOPYRIMIDINEDIONE; SULFONE; SULFOXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; ENZYME INHIBITION; HELICOBACTER PYLORI; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MICROSOME; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN;

AMINO ACID ISOMERASES; ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL AVAILABILITY; DRUG DESIGN; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; INHIBITORY CONCENTRATION 50; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; PRODRUGS; PROTEIN BINDING; SULFOXIDES; TIME FACTORS;

HELICOBACTER PYLORI; MUS;

EID: 48849113288 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2008.06.092 Document Type: Article

Times cited : (31)

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