4-Substituted D-glutamic acid analogues: The first potent inhibitors of glutamate racemase (MurI) enzyme with antibacterial activity

Journal of Medicinal Chemistry

Volumn 45, Issue 20, 2002, Pages 4559-4570

  De Dios, Alfonso ^a   Prieto, Lourdes ^a   Martín, Jose Alfredo ^a   Rubio, Almudena ^a,b   Ezquerra, Jesus ^a   Tebbe, Mark ^b   López De Uralde, Beatriz ^a   Martín, Justina ^c   Sánchez, Ana ^c   LeTourneau, Deborah L ^b   McGee, James E ^b   Boylan, Carole ^b   Parr Jr , Thomas R ^b,d   Smith, Michele C ^b  

^a ELI LILLY AND COMPANY   (Spain)

^b ELI LILLY AND COMPANY   (United States)

^c UNIVERSITY OF ALCALÁ   (Spain)

^d Xenogen Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 (2 BENZO[B]THIENYL)METHYL PENTANEDIOIC ACID; 2 AMINO 4 (2 NAPHTHYL)METHYL PENTANEDIOIC ACID; 2 AMINO 4 [(3 CHLORO)2 BENZO[B]THIENYL]METHYL PENTANEDIOIC ACID; GLUTAMATE RACEMASE; GLUTAMIC ACID DERIVATIVE; RACEMASE; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITOR INTERACTION; IC 50; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; MOUSE; NONHUMAN; STAPHYLOCOCCUS AUREUS; STEREOCHEMISTRY; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE;

AMINO ACID ISOMERASES; ANIMALS; ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; GLUTAMATES; MICE; MICROBIAL SENSITIVITY TESTS; PNEUMOCOCCAL INFECTIONS; STEREOISOMERISM; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037179637     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020901d     Document Type: Article

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