Structural and Functional Analysis of Two Glutamate Racemase Isozymes from Bacillus anthracis and Implications for Inhibitor Design

Journal of Molecular Biology

Volumn 371, Issue 5, 2007, Pages 1219-1237

  May, Melissa ^a   Mehboob, Shahila ^a   Mulhearn, Debbie C ^a   Wang, Zhiqiang ^a   Yu, Huidong ^a   Thatcher, Gregory R J ^a   Santarsiero, Bernard D ^a   Johnson, Michael E ^a   Mesecar, Andrew D ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

antimicrobial drug design; Bacillus anthracis; broad spectrum inhibitors; cofactor independent racemase; glutamate racemase isozymes

Indexed keywords

ALANINE; DIMER; GLUTAMIC ACID; ISOENZYME; MONOMER; RACE1 ISOENZYME; RACE2 ISOENZYME; RACEMASE; UNCLASSIFIED DRUG; VALINE;

AQUIFEX PYROPHILUS; ARTICLE; BACILLUS ANTHRACIS; BACILLUS SUBTILIS; BACTERIAL GENOME; BACTERIAL STRAIN; CATALYSIS; DIMERIZATION; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN QUATERNARY STRUCTURE; RACEMIZATION; STEADY STATE; STRUCTURE ANALYSIS;

AQUIFEX PYROPHILUS; BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS);

EID: 34547557316     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.05.093     Document Type: Article

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