Effects of Lactobacillus casei Shirota ingestion on common cold infection and herpes virus antibodies in endurance athletes: a placebo-controlled, randomized trial

European Journal of Applied Physiology

Volumn 116, Issue 8, 2016, Pages 1555-1563

  Gleeson, Michael ^a   Bishop, Nicolette C ^a   Struszczak, Lauren ^a  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

Author keywords

Common cold; Exercise training; Herpesvirus; Probiotic

Indexed keywords

PROBIOTIC AGENT; VIRUS ANTIBODY;

ADULT; BLOOD; COMMON COLD; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENDURANCE; FEMALE; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; LACTOBACILLUS CASEI; MACACINE HERPESVIRUS 1; MALE; PLACEBO EFFECT; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTIONS; SPORT; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME; UNITED KINGDOM; VIROLOGY;

ADULT; ANTIBODIES, VIRAL; COMMON COLD; DOUBLE-BLIND METHOD; FEMALE; HERPESVIRUS 1, CERCOPITHECINE; HUMANS; LACTOBACILLUS CASEI; MALE; PHYSICAL ENDURANCE; PLACEBO EFFECT; PROBIOTICS; RESPIRATORY TRACT INFECTIONS; SPORTS; TREATMENT OUTCOME; UNITED KINGDOM;

EID: 84974851926     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-016-3415-x     Document Type: Article

References (42)

1. Alonso Arias R, Moro-García MA, Echeverría A, Solano-Jaurrieta JJ, Suárez-García FM, López-Larrea C (2013) Intensity of the humoral response to cytomegalovirus is associated with the phenotypic and functional status of the immune system. J Virol 87(8):4486–4495
2. Clancy RL, Gleeson M, Cox A, Callister R, Dorrington M, D’Este C, Pang G, Pyne D, Fricker P, Henriksson A (2006) Reversal in fatigued athletes of a defect in interferon gamma secretion after administration of Lactobacillus acidophilus. Br J Sports Med 40:351–354
3. Cox AJ, Pyne DB, Saunders PU, Fricker PA (2010) Oral administration of the probiotic Lactobacillus fermentum VRI-003 and mucosal immunity in endurance athletes. Br J Sports Med 44(4):222–226
4. Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P (2003) International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 35(8):1381–1395
5. Dong H, Rowland I, Tuohy KM, Thomas LV, Yaqoob P (2010) Selective effects of Lactobacillus casei Shirota on T cell activation, natural killer cell activity and cytokine production. Clin Exp Immunol 161(2):378–388
6. Dong H, Rowland I, Yaqoob P (2012) Comparative effects of six probiotic strains on immune function in vitro. Br J Nutr 108(3):459–470
7. Dowd JB, Aiello AE, Chyu L, Huang YY, McDade TW (2011) Cytomegalovirus antibodies in dried blood spots: a minimally invasive method for assessing stress, immune function, and aging. Immun Ageing 8(1):3
8. Faul F, Erdfelder E, Buchner A, Lang AG (2009) Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 41(4):1149–1160
9. Glaser R, Kiecolt-Glaser JK, Speicher CE, Holliday JE (1985) Stress, loneliness, and changes in herpesvirus latency. J Behav Med 8(3):249–260
10. Glaser R, Friedman SB, Smyth J, Ader R, Bijur P, Brunell P, Cohen N, Krilov LR, Lifrak ST, Stone A, Toffler P (1999) The differential impact of training stress and final examination stress on herpesvirus latency at the United States Military Academy at West Point. Brain Behav Immun 13(3):240–251
11. Gleeson M (2016) Immunological aspects of sport nutrition. Immunol Cell Biol 4(2):117–123
12. Gleeson M, Walsh NP (2012) The BASES expert statement on exercise, immunity, and infection. J Sports Sci 30(3):321–324
13. Gleeson M, Bishop NC, Oliveira M, Tauler PJ (2011) Daily probiotic’s (Lactobacillus casei Shirota) reduction of infection incidence in athletes. Int J Sport Nutr Exerc Metab 21:55–64
14. Gleeson M, Bishop NC, Oliveira M, McCauley T, Tauler P, Lawrence C (2012) Effects of a Lactobacillus salivarius probiotic intervention on infection, cold symptom duration and severity, and mucosal immunity in endurance athletes. Int J Sport Nutr Exerc Metab 22(4):235–242
15. Gleeson M, Bishop NC, Oliveira M, McCauley T, Tauler P (2013a) Influence of training load on upper respiratory tract infection incidence and antigen-stimulated cytokine production. Scand J Med Sci Sports 23:451–457
16. Gleeson M, Bishop NC, Walsh NP (2013b) Exercise immunology. Routledge, London
17. Godbout JP, Glaser R (2006) Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer. J Neuroimmune Pharmacol 1(4):421–427
18. Hadrup SR, Strindhall J, Køllgaard T, Seremet T, Johansson B, Pawelec G, thor Straten P, Wikby A (2006) Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J Immunol 176(4):2645–2653
19. Hao Q, Dong BR, Wu T (2015) Probiotics for preventing acute upper respiratory tract infections. Cochrane Database Syst Rev 2:CD006895
20. Haywood BA, Black KE, Baker D, McGarvey J, Healey P, Brown RC (2014) Probiotic supplementation reduces the duration and incidence of infections but not severity in elite rugby union players. J Sci Med Sport 17:356–360
21. He CS, Handzlik M, Muhamad A, Gleeson M (2013) Influence of CMV/EBV serostatus on respiratory infection incidence during 4 months of winter training in a student cohort of endurance athletes. Eur J Appl Physiol 113:2613–2619
22. Jackson GG, Dowling HF, Spiesman IG, Boano AV (1958) Transmission of the common cold to volunteers under controlled conditions. Arch Intern Med 101:267–278
23. Kekkonen RA, Vasankari TJ, Vuorimaa T, Haahtela T, Julkunen I, Korpela R (2007) The effect of probiotics on respiratory infections and gastrointestinal symptoms during training in marathon runners. Int J Sport Nutr Exerc Metab 17:352–383
24. King S, Glanville J, Sanders ME, Fitzgerald A, Varley D (2014) Effectiveness of probiotics on the duration of illness in healthy children and adults who develop common acute respiratory infectious conditions: a systematic review and meta-analysis. Br J Nutr 112(1):41–54
25. ® L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized double-blind placebo-controlled trial. J Appl Physiol Nutr Metab 2016a (in press)
26. ® L10 supplementation modulates mucosal and humoral immunity in elite athletes (in a randomized double-blinded placebo-controlled trial). J Strength Cond Res (in press)
27. Matsumoto K, Takada T, Shimizu K, Kado Y, Kawakami K, Makino I, Yamaoka Y, Hirano K, Nishimura A, Kajimoto O, Nomoto K (2006) The effects of a probiotic milk product containing Lactobacillus casei strain Shirota on the defecation frequency and the intestinal microflora of sub-optimal health state volunteers: a randomized placebo-controlled cross-over study. Bioscience Microflora 25(2):39–48
28. Matsuzaki T (1998) Immunomodulation by treatment with Lactobacillus casei strain Shirota. Int J Food Microbiol 41(2):133–140
29. Moro-García MA, Alonso-Arias R, Baltadjieva M, Fernández Benítez C, Fernández Barrial MA, Díaz Ruisánchez E, Alonso Santos R, Alvarez Sánchez M, Saavedra Miján J, López-Larrea C (2013) Oral supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 enhances systemic immunity in elderly subjects. Age 35(4):1311–13263
30. Nagao F, Nakayama M, Muto T, Okumura K (2000) Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the immune system in healthy human subjects. Biosci Biotech Biochem 64(12):2706–2708
31. Nieman DC, Johanssen LM, Lee IW, Arabatzis K (1990) Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness 30(3):316–328
32. Predy GN, Goel V, Lovlin R, Donner A, Stitt L, Basu TK (2005) Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. Can Med Assoc J 173(9):1043–1048
33. Public Health England National Weekly Influenza Report (2015) https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/445791/Weekly_report_summary_wk29_16July2015.pdf
34. Pyne DB, West NP, Cox AJ, Cripps AW (2015) Probiotics supplementation for athletes—clinical and physiological effects. Eur J Sport Sci 15(1):63–72
35. Simpson RJ, Bigley AB, Spielmann G, LaVoy EC, Kunz H, Bollard CM (2016) Human cytomegalovirus infection and the immune response to exercise. Exerc Immunol Rev 22:8–27
36. Spanhaak S, Havenaar R, Schaafsma G (1998) The effect of consumption of milk frermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans. Eur J Clin Nutr 52(12):899–907
37. Tiollier E, Chennaoui M, Gomez-Marino D, Drogou C, Filaire E, Guezennec CY (2007) Effect of a probiotic supplementation on respiratory infections and immune and hormonal parameters during intense military training. Mil Med 172(9):1006–1011
38. Trejo F, Sanz Y (2013) Intestinal bacteria and probiotics: effects on the immune system and impacts on human health. In: Calder PC, Yaqoob P (eds) Diet, immunity and inflammation. Woodhead Publishing, Cambridge, UK, pp 267–291
39. Walsh NP, Gleeson M, Shephard RJ, Gleeson M, Woods JA, Bishop NC, Fleshner M, Green C, Pedersen BK, Hoffman-Goetz L, Rogers CJ, Northoff H, Abbasi A, Simon P (2011a) Position statement part one: immune function and exercise. Exerc Immunol Rev 17:6–63
40. Walsh NP, Gleeson M, Pyne DB, Nieman DC, Dhabhar FS, Shephard RJ, Oliver SJ, Bermon S, Kajeniene A (2011b) Position statement part two: maintaining immune health. Exerc Immunol Rev 17:64–103
41. ®) supplementation and gastrointestinal and respiratory tract illness symptoms: a randomised control trial in athletes. Nutr J 10:30
42. West NP, Horn PL, Pyne DB, Gebski VJ, Lahtinen SJ, Fricker PA, Cripps AW (2014) Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals. Clin Nutr 33:581–587