Influence of training load on upper respiratory tract infection incidence and antigen-stimulated cytokine production

Scandinavian Journal of Medicine and Science in Sports

Volumn 23, Issue 4, 2013, Pages 451-457

  Gleeson, M ^a   Bishop, N ^a   Oliveira, M ^a   Tauler, P ^b  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^b UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

Exercise; Illness; Immunity; Interleukins; Leukocytes

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN; INTERLEUKIN DERIVATIVE;

ADOLESCENT; ADULT; ARTICLE; BIOSYNTHESIS; DISEASES; ENDURANCE; EXERCISE; FEMALE; HUMAN; IMMUNITY; IMMUNOLOGY; LEUKOCYTE; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; METABOLISM; PHYSIOLOGY; RESPIRATORY TRACT INFECTION; SALIVA; YOUNG ADULT;

EXERCISE; ILLNESS; IMMUNITY; INTERLEUKINS; LEUKOCYTES;

ADOLESCENT; ADULT; CYTOKINES; EXERCISE; FEMALE; HUMANS; IMMUNOGLOBULINS; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; PHYSICAL ENDURANCE; RESPIRATORY TRACT INFECTIONS; SALIVA; YOUNG ADULT;

EID: 84880514541     PISSN: 09057188     EISSN: 16000838     Source Type: Journal    
DOI: 10.1111/j.1600-0838.2011.01422.x     Document Type: Article

References (41)

1. Besisle SE, Hamer DH, Leka LS, Dalla GE, Delgado-Lista J, Fine BC, Jacques PF, Ordovas JM, Meydani SN. IL-2 and IL-10 gene polymorphisms are associated with respiratory tract infection and may modulate the effect of vitamin E on lower respiratory tract infections in elderly nursing home residents. Am J Clin Nutr 2010: 92: 106-114.
2. Bishop NC. Exercise and infection risk. In: Gleeson M, ed. Immune function in sport and exercise. Edinburgh: Elsevier, 2005: 1-14.
3. Blackburn SD, Wherry EJ. IL-10, T cell exhaustion and viral persistence. Trends Microbiol 2007: 15: 143-146.
4. hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 2010: 32: 129-140.
5. Castell LM, Poortmans JR, Leclercq R, Brasseur M, Duchateau J, Newsholme EA. Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation. Eur J Appl Physiol 1997: 75: 47-53.
6. Clancy RL, Gleeson M, Cox A, Callister R, Dorrington M, D'Este C, Pang G, Pyne D, Fricker P, Henriksson A. Reversal in fatigued athletes of a defect in interferon gamma secretion after administration of lactobacillus acidophilus. Br J Sports Med 2006: 40: 351-354.
7. Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003: 35: 1381-1395.
8. Davis JM, Murphy EA, Brown AS, Carmichael MD, Ghaffar A, Mayer EP. Effects of moderate exercise and oat {beta}-glucan on innate immune function and susceptibility to respiratory infection. Am J Physiol Regul Integr Comp Physiol 2004: 286: R366-R372.
9. Fahlman MM, Engels HJ. Mucosal IgA and URTI in American college football players: a year longitudinal study. Med Sci Sports Exerc 2005: 37: 374-380.
10. Fricker PA, Pyne DB, Saunders PU, Cox AJ, Gleeson M, Telford RD. Influence of training loads on patterns of illness in elite distance runners. Clin J Sport Med 2005: 15: 246-252.
11. Fujio K, Okamura T, Yamamoto K. The family of IL-10-secreting CD4+ cells. Adv Immunol 2010: 105: 99-130.
12. Gleeson M, Bishop NC, Oliveira M, McCauley T, Tauler P. Sex differences in immune variables and respiratory infection incidence in an athletic population. Exerc Immunol Rev 2011a: 17: 122-135.
13. Gleeson M, Bishop NC, Oliveira M, Tauler P. Daily probiotic's (Lactobacillus casei Shirota) reduction of infection incidence in athletes. Int J Sport Nutr Exerc Metab 2011b: 21: 55-64.
14. Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 2011c: 11: 607-615.
15. Gleeson M, McDonald WA, Pyne DB, Cripps AW, Francis JL, Fricker PA, Clancy RL. Salivary IgA levels and infection risk in elite swimmers. Med Sci Sports Exerc 1999: 31: 67-73.
16. Heath GW, Macer CA, Nieman DC. Exercise and upper respiratory tract infections: is there a relationship? Sports Med 1992: 14: 353-365.
17. Lancaster GI, Halson SL, Khan Q, Drysdale P, Wallace F, Jeukendrup AE, Drayson MT, Gleeson M. Effects of acute exhaustive exercise and chronic exercise training on type 1 and type 2 lymphocytes. Exerc Immunol Rev 2004: 10: 91-106.
18. Lancaster GI, Khan Q, Drysdale P, Wallace F, Jeukendrup AE, Drayson MT, Gleeson M. The physiological regulation of toll-like receptor expression and function in humans. J Physiol 2005: 563: 945-955.
19. Malek TR. The main function of IL-2 is to promote the development of T regulatory cells. J Leukoc Biol 2003: 74: 961-965.
20. Matthews CE, Ockene IS, Freedson PS, Rosal MC, Merriam PA, Hebert JR. Moderate to vigorous physical activity and risk of upper-respiratory tract infection. Med Sci Sports Exerc 2002: 34: 1242-1248.
21. Maynard CL, Weaver CT. Diversity in the contribution of IL-10 to cell-mediated immune regulation. Immunol Rev 2008: 226: 219-233.
22. McFarlin BK, Flynn MG, Campbell WW, Craig BA, Robinson PJ, Stewart LK, Timmermann KL, Coen PM. Physical activity status, but not age, influences inflammatory biomarkers and toll-like receptor 4. J Gerontol 2006: 61: 388-393.
23. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001: 19: 683-765.
24. Murphy EA, Davis JM, Brown AS, Carmichael MD, Van Rooijen N, Ghaffar A, Mayer EP. Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training. Am J Physiol Regul Integr Comp Physiol 2004: 287: R1354-R1358.
25. Nieman DC. Is infection risk linked to exercise workload? Med Sci Sports Exerc 2000: 32: S406-S411.
26. Nieman DC, Henson DA, Austin MD, Sha W. Upper respiratory tract infection is reduced in physically fit and active adults. Br J Sports Med 2011: 45: 987-992.
27. Nieman DC, Johanssen LM, Lee IW, Arabatzis K. Infectious episodes in runners before and after the Los Angeles marathon. J Sports Med Phys Fitness 1990: 30: 316-328.
28. Okutsu M, Yoshida Y, Zhang X, Tamagawa A, Ohkubo T, Tsuji I, Nagatomi R. Exercise training enhances in vivo tuberculosis purified protein derivative response in the elderly. J Appl Physiol 2008: 104: 1690-1696.
29. Oliveira M, Gleeson M. The influence of prolonged cycling on monocyte toll-like receptor 2 and 4 expression in healthy men. Eur J Appl Physiol 2010: 109: 251-257.
30. Ollier WE. Cytokine genes and disease susceptibility. Cytokine 2004: 28: 174-178.
31. Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 2000: 80: 1055-1081.
32. Peters EM, Bateman ED. Ultramarathon running and URTI: an epidemiological survey. S Afr Med J 1983: 64: 582-584.
33. Steensberg A, Toft AD, Bruunsgaard H, Sandmand M, Halkjar-Kristensen J, Pedersen BK. Strenuous exercise decreases the percentage of type 1 T cells in the circulation. J Appl Physiol 2001: 91: 1708-1712.
34. Stewart LK, Flynn MG, Campbell WW, Craig BA, Robinson JP, McFarlin BK, Timmerman KL, Coen PM, Felker J, Talbert E. Influence of exercise training and age on CD14+ cell surface expression of toll-like receptor 2 and 4. Brain Behav Immun 2005: 19: 389-397.
35. Sugiura H, Sugiura H, Nishida H, Inaba R, Mirbod SM, Iwata H. Effects of different durations of exercise on macrophage functions in mice. J Appl Physiol 2001: 90: 789-794.
36. Sugiura H, Nishida H, Sugiura H, Mirbod SM. Immunomodulatory action of chronic exercise on macrophage and lymphocyte cytokine production in mice. Acta Physiol Scand 2002: 174: 247-256.
37. Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K. Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc Immunol Rev 2002: 8: 6-48.
38. Teixeira AM, Rama L, Borges G, Henriques A, Azevedo S, Alves F, Paiva A. Increase in T regulatory lymphocytes after a winter training season in swimmers. Proc 10th ISEI Symp, Oxford: 11-13 July 2011. Abstract available at http://www.isei.dk.
39. van der Sluijs KF, van Elden LJ, Nijhuis M, Schuurman R, Pater JM, Florquin S, Goldman M, Jansen HM, Lutter R, van der Poll T. IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection. J Immunol 2004: 172: 7603-7609.
40. Wang J, Song H, Tang X, Yang Y, Vieira VJ, Niu Y, Ma Y. Effect of exercise training intensity on murine T-regulatory cells and vaccination response. Scand J Med Sci Sports 2012: 22 (5): 643-652.
41. Yeh S-H, Chuang H, Lin L-, Hsiao C-Y, Eng HL. Regular tai chi chuan exercise enhances functional mobility and CD4CD25 regulatory cells. Br J Sports Med 2006: 40: 239-243.