Lactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial

Journal of Strength and Conditioning Research

Volumn 31, Issue 1, 2017, Pages 62-70

  Michalickova, Danica M ^a   Kostic Vucicevic, Marija M ^b   Vukasinovic Vesic, Milica Dj ^b   Stojmenovic, Tamara B ^b   Dikic, Nenad V ^b   Andjelkovic, Marija S ^b   Djordjevic, Brizita I ^a   Tanaskovic, Bojana P ^c   Minic, Rajna D ^c  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b Sports Medicine Association of Serbia   (Serbia)

^c Vaccines and Sera   (Serbia)

Author keywords

Immune system; Immunoglobulins; Probiotics; Salivary IgA

Indexed keywords

BACTERIUM ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PROBIOTIC AGENT;

ADULT; ATHLETE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMORAL IMMUNITY; IMMUNOLOGY; LACTOBACILLUS HELVETICUS; MALE; MUCOSAL IMMUNITY; OXYGEN CONSUMPTION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SALIVA; YOUNG ADULT;

ADULT; ANTIBODIES, BACTERIAL; ATHLETES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMMUNITY, HUMORAL; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LACTOBACILLUS HELVETICUS; MALE; OXYGEN CONSUMPTION; PROBIOTICS; SALIVA; YOUNG ADULT;

EID: 85017484618     PISSN: 10648011     EISSN: 15334295     Source Type: Journal    
DOI: 10.1519/JSC.0000000000001456     Document Type: Article

References (40)

1. Ainsworth, BE, Haskell, WL, Herrmann, SD, Meckes, N, Bassett, DR Jr, Tudor-Locke, C, Greer, JL, Vezina, J, Whitt- Glover, MC, and Leon, AS. Compendium of physical activities: A second update of codes and MET values. Med Sci Sports Exerc 43: 1575-1581, 2011.
2. Alberda, C, Gramlich, L, Meddings, J, Field, C, McCargar, L, Kutsogiannis, D, Fedorak, R, and Madsen, K. Effects of probiotic therapy in critically ill patients: A randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 85: 816-823, 2007.
3. Albers, R, Antoine, JM, Bourdet-Sicard, R, Calder, PC, Gleeson, M, Lesourd, B, and Watzl, B. Markers to measure immunomodulation in human nutrition intervention studies. Br J Nutr 94: 452-481, 2005.
4. Baralic, I, Andjelkovic, M, Djordjevic, B, Dikic, N, Radivojevic, N, Suzin-Zivkovic, V, and Pejic, S. Effect of astaxanthin supplementation on salivary IgA, oxidative stress, and inflammation in young soccer players. Evid Based Complement Alternat Med 2015: 783761, 2015.
5. Brandtzaeg, P, Karlsson, G, Hansson, G, Petruson, B, Björkander, J, and Hanson, LA. The clinical condition of IgA-deficient patients is related to the proportion of IgD- and IgM-producing cells in their nasal mucosa. Clin Exp Immunol 67: 626-636, 1987.
6. Bunker, JJ, Flynn, TM, Koval, JC, Shaw, DG, Meisel, M, McDonald, BD, and Bendelac, A. Innate and adaptive humoral responses coat distinct commensal bacteria with immunoglobulin A. Immunity 43: 541-553, 2015.
7. Christensen, HR, Larsen, CN, Kæstel, P, Rosholm, LB, Sternberg, C, Michaelsen, KF, and Frøkiær, H. Immunomodulating potential of supplementation with probiotics: A dose-response study in healthy young adults. FEMS Immunol Med Microbiol 47: 380-390, 2006.
8. Clancy, RL, Gleeson, M, Cox, A, Callister, R, Dorrington, M, D'Este, C, Pang, G, Pyne, D, Fricker, P, and Henriksson, A. Reversal in fatigued athletes of a defect in interferon-g secretion after administration of Lactobacillus acidophilus. Br J Sports Med 40: 351-354, 2006.
9. Corthesy, B, Boris, S, Isler, P, Grangette, C, and Mercenier, A. Oral immunization of mice with lactic acid bacteria producing Helicobacter pylori urease B subunit partially protects against challenge with Helicobacter felis. J Infect Dis 192: 1441-1449, 2005.
10. Cox, AJ, Pyne, DB, Saunders, PU, and Fricker, PA. Oral administration of the probiotic Lactobacillus fermentum VRI-003 and mucosal immunity in endurance athletes. Br J Sports Med 44: 222-226, 2010.
11. Crago, SS, Kutteh, WH, Moro, I, Allansmith, MR, Radl, J, Haaijman, JJ, and Mestecky, J. Distribution of IgA1, IgA2-, and J chain containing cells in human tissues. J Immunol 132: 16-18, 1984.
12. Daele, J and Zicot, AF. Humoral immunodeficiency in recurrent upper respiratory tract infections. Some basic, clinical and therapeutic features. Acta Otorhinolaryngol Belg 54: 373-390, 2000.
13. Forrest, BD. Indirect measurement of intestinal immune responses to an orally administered attenuated bacterial vaccine. Infect Immun 60: 2023-2029, 1992.
14. Gleeson, M, Pyne, DB, and Callister, R. The missing links in exercise effects on mucosal immunity. Exerc Immunol Rev 10: 107-128, 2004.
15. Gleeson, M, Bishop, NC, Oliveira, M, and Tauler, P. Daily probiotic's (Lactobacillus casei Shirota) reduction of infection incidence in athletes. Int J Sport Nutr Exerc Metab 21: 55-64, 2011.
16. Gleeson, M, Bishop, N, Oliveira, M, McCauley, T, Tauler, P, and Lawrence, C. Effects of a Lactobacillus salivarius probiotic intervention on infection, cold symptom duration and severity, and mucosal immunity in endurance athletes. Int J Sport Nutr Exerc Metab 22: 235-242, 2012.
17. Hanson, PG and Flaherty, DK. Immunological responses to training in conditioned runners. Clin Sci (Lond) 60: 225-228, 1981.
18. Hellard, P, Avalos, M, Guimaraes, F, Toussaint, JF, and Pyne, DB. Training-related risk of common illnesses in elite swimmers over a 4-yr period. Med Sci Sport Exer 47: 698-707, 2015.
19. Israel, S, Buhl, B, Krause, M, and Neumann, G. Die Konzentration der Immunglobuline A, G und M im Serum bei Trainierten und untrainierten sowie nach verschiedenen sportlicken Ausdauerleistungen. Med Sport 22: 225-231, 1982.
20. Kaminogawa, S and Nanno, M. Modulation of immune functions by foods. Evid Based Complement Alternat Med 1: 241-250, 2004.
21. Kemgang, TS, Kapila, S, Shanmugam, VP, and Kapila, R. Cross-talk between probiotic lactobacilli and host immune system. J Appl Microbiol 117: 303-319, 2014.
22. Kerr, MA. The structure and function of human IgA. Biochem J 271: 285-296, 1990.
23. Kutteh, WH, Prince, SJ, and Mestecky, J. Tissue origins of human polymeric and monomeric IgA. J Immunol 128: 990-995, 1982.
24. Lowry, OH, Rosebrough, NJ, Farr, AL, and Randall, RJ. Protein measurement with the Folin Phenol Reagent. J Biol Chem 193: 267- 275, 1951.
25. Macpherson, AJ, Gatto, D, Sainsbury, E, Harriman, GR, Hengartner, H, and Zinkernagel, RM. A primitive T cell independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288: 2222-2226, 2000.
26. Monteiro, RC and Van De Winkel, JG. IgA Fc receptors. Annu Rev Immunol 21: 177-204, 2003.
27. Nieman, DC and Nehlsen-Cannarella, SL. The effects of acute and chronic exercise on immunoglobulins. Sports Med 11: 183-201, 1991.
28. Ouwehand, AC, Ten Bruggencate, SJM, Schonewille, AJ, Alhoniemi, E, Forssten, SD, and Bovee-Oudenhoven, IMJ. Lactobacillus acidophilus supplementation in human subjects and their resistance to enterotoxigenic Escherichia coli infection. Br J Nutr 111: 465-473, 2014.
29. Paineau, D, Carcano, D, Leyer, G, Darquy, S, Alyanakian, MA, Simoneau, G, Bergmann, JF, Brassart, D, Bornet, F, and Ouwehand, AC. Effects of seven potential probiotic strains on specific immune responses in healthy adults: A double-blind, randomized, controlled trial. FEMS Immunol Med Microbiol 53: 107-113, 2008.
30. Paturi, G, Phillips, M, and Kailasapathy, KS. Effect of probiotic strains Lactobacillus acidophilus LAFTI L10 and Lactobacillus paracasei LAFTI L26 on systemic immune functions and bacterial translocation in mice. J Food Prot 71: 796-801, 2008.
31. Shimizu, K, Sato, H, Suga, Y, Yamahira, S, Toba, M, Hamuro, K, and Kuno, S. The effects of Lactobacillus pentosus strain b240 and appropriate physical training on salivary secretory IgA levels in elderly adults with low physical fitness: A randomized, double-blind, placebo-controlled trial. J Clin Biochem Nutr 54: 61-66, 2014.
32. Sindhu, KN, Sowmyanarayanan, TV, Paul, A, Babji, S, Ajjampur, SS, Priyadarshini, S, and Kang, G. Immune response and intestinal permeability in children with acute gastroenteritis treated with Lactobacillus rhamnosus GG: A randomized, double-blind, placebocontrolled trial. Clin Infect Dis 58: 1107-1115, 2014.
33. Solomon, A. In: Monoclonal Immunoglobulins as Biomarkers of Cancer. In: Cancer markers. S Sell, ed. Clifton, NJ: Humana Press, 1980. pp. 57-87.
34. Stojanović, M, Inić -Kanada, A, Popović, Z, Ž ivković, I, and Dimitrijevíc, L. Changes in pools of autoantibodies and antibacterial antibodies in patients suffering from recurrent infections of the urinary tract and undergoing bacterial immunization treatment. Immunol Lett 94: 123-133, 2004.
35. Tomasi, TB and Plaut, AG. In: Humoral Aspects of Mucosal Immunity. In: Advances in host defense mechanisms. A JI Gallin and S Fauci, eds. New York, NY: Raven Press, 1985. pp. 31-61.
36. Tiollier, E, Chennaoui, M, Gomez-Merino, D, Drogou, C, Filaire, E, and Guezennec, CY. Effect of a probiotics supplementation on respiratory infections and immune and hormonal parameters during intense military training. Mil Med 172: 1006-1011, 2007.
37. Walsh, NP, Gleeson, M, Shephard, RJ, Gleeson, M, Woods, JA, Bishop, NC, Fleshner, M, Green, C, Pedersen, BK, Hoffman- Goetz, L, Rogers, CJ, Northoff, H, Abbasi, A, and Simon, P. Position statement. Part one: Immune function and exercise. Exerc Immunol Rev 17: 6-63, 2011.
38. Wang, Y, Gao, L, Zhang, Y, Shi, C, and Ren, C. Efficacy of probiotic therapy in full-term infants with critical illness. Asia Pac J Clin Nutr 23: 575-580, 2014.
39. West, NP, Pyne, DB, Cripps, AW, Hopkins, WG, Eskesen, DC, Jairath, A, and Fricker, PA. Lactobacillus fermentum (PCC (R)) supplementation and gastrointestinal and respiratory-tract illness symptoms: A randomised control trial in athletes. Nutr J 10: 30, 2011.
40. West, NP, Horn, PL, Pyne, DB, Gebski, VJ, Lahtinen, SJ, Fricker, PA, and Cripps, AW. Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals. Clin Nutr 33: 581-587, 2014.