LRRK2 autophosphorylation enhances its GTPase activity

FASEB Journal

Volumn 30, Issue 1, 2016, Pages 336-347

  Liu, Zhiyong ^a,b   Mobley, James A ^c   Delucas, Lawrence J ^b   Kahn, Richard A ^d   West, Andrew B ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c Kentucky   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

G protein; GTP hydrolysis; Parkinson disease; Phosphorylation; ROC

Indexed keywords

DIMER; DYNAMIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; LEUCINE RICH REPEAT KINASE 2; MONOMER; LRRK2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; PROTOZOAL PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; CATALYSIS; COMPUTER MODEL; CONFORMATIONAL TRANSITION; DIFFERENTIAL SCANNING CALORIMETRY; DIMERIZATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HYDROLYSIS; MASS SPECTROMETRY; PRIORITY JOURNAL; SIZE EXCLUSION CHROMATOGRAPHY; STOICHIOMETRY; AMOEBA (LIFE CYCLE STAGE); CHEMISTRY; ENZYMOLOGY; HUMAN; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; AMOEBA; GTP PHOSPHOHYDROLASES; GUANOSINE TRIPHOSPHATE; HUMANS; LEUCINE-RICH REPEAT SERINE-THREONINE PROTEIN KINASE-2; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTOZOAN PROTEINS;

EID: 84974784616     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-277095     Document Type: Article

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