-
1
-
-
66949152096
-
Parkinson's disease
-
CrossRef PubMed
-
Lees, A. J., Hardy, J. and Revesz, T. (2009) Parkinson's disease. Lancet 373, 2055-2066 CrossRef PubMed
-
(2009)
Lancet
, vol.373
, pp. 2055-2066
-
-
Lees, A.J.1
Hardy, J.2
Revesz, T.3
-
2
-
-
8844266996
-
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
-
CrossRef PubMed
-
Paisán-Ruiz, C., Jain, S., Evans, E. W., Gilks, W. P., Simón, J., van der, B. M., López de Munain, A., Aparicio, S., Gil, A. M., Khan, N. et al. (2004) Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44, 595-600 CrossRef PubMed
-
(2004)
Neuron
, vol.44
, pp. 595-600
-
-
Paisán-Ruiz, C.1
Jain, S.2
Evans, E.W.3
Gilks, W.P.4
Simón, J.5
Van Der, B.M.6
De López Munain, A.7
Aparicio, S.8
Gil, A.M.9
Khan, N.10
-
3
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
CrossRef PubMed
-
Zimprich, A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M., Lincoln, S., Kachergus, J., Hulihan, M., Uitti, R. J., Calne, D. B. et al. (2004) Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44, 601-607 CrossRef PubMed
-
(2004)
Neuron
, vol.44
, pp. 601-607
-
-
Zimprich, A.1
Biskup, S.2
Leitner, P.3
Lichtner, P.4
Farrer, M.5
Lincoln, S.6
Kachergus, J.7
Hulihan, M.8
Uitti, R.J.9
Calne, D.B.10
-
4
-
-
19944432921
-
A common LRRK2 mutation in idiopathic Parkinson's disease
-
PubMed
-
Gilks, W. P., Abou-Sleiman, P. M., Gandhi, S., Jain, S., Singleton, A., Lees, A. J., Shaw, K., Bhatia, K. P., Bonifati, V., Quinn, N. P. et al. (2005) A common LRRK2 mutation in idiopathic Parkinson's disease. Lancet 365, 415-416 PubMed
-
(2005)
Lancet
, vol.365
, pp. 415-416
-
-
Gilks, W.P.1
Abou-Sleiman, P.M.2
Gandhi, S.3
Jain, S.4
Singleton, A.5
Lees, A.J.6
Shaw, K.7
Bhatia, K.P.8
Bonifati, V.9
Quinn, N.P.10
-
5
-
-
0345118282
-
Roc, a Ras/GTPase domain in complex proteins
-
CrossRef PubMed
-
Bosgraaf, L. and van Haastert, P. J. (2003) Roc, a Ras/GTPase domain in complex proteins. Biochim. Biophys. Acta 1643, 5-10 CrossRef PubMed
-
(2003)
Biochim. Biophys. Acta
, vol.1643
, pp. 5-10
-
-
Bosgraaf, L.1
Van Haastert, P.J.2
-
6
-
-
77953890085
-
Parkinson's disease: Insights from pathways
-
CrossRef PubMed
-
Cookson, M. R. and Bandmann, O. (2010) Parkinson's disease: insights from pathways. Hum. Mol. Genet. 19, R21-R27 CrossRef PubMed
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. R21-R27
-
-
Cookson, M.R.1
Bandmann, O.2
-
7
-
-
33746267531
-
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
-
CrossRef PubMed
-
Greggio, E., Jain, S., Kingsbury, A., Bandopadhyay, R., Lewis, P., Kaganovich, A., van der Brug, M. P., Beilina, A., Blackinton, J., Thomas, K. J. et al. (2006) Kinase activity is required for the toxic effects of mutant LRRK2/dardarin. Neurobiol. Dis. 23, 329-341 CrossRef PubMed
-
(2006)
Neurobiol. Dis.
, vol.23
, pp. 329-341
-
-
Greggio, E.1
Jain, S.2
Kingsbury, A.3
Bandopadhyay, R.4
Lewis, P.5
Kaganovich, A.6
Van Der Brug, M.P.7
Beilina, A.8
Blackinton, J.9
Thomas, K.J.10
-
8
-
-
34548432121
-
Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation
-
CrossRef PubMed
-
Luzón-Toro, B., Rubio, d.l.T., Delgado, A., Pérez-Tur, J. and Hilfiker, S. (2007) Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation. Hum. Mol. Genet. 16, 2031-2039 CrossRef PubMed
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 2031-2039
-
-
Luzón-Toro, B.1
Rubio, D.L.T.2
Delgado, A.3
Pérez-Tur, J.4
Hilfiker, S.5
-
9
-
-
28044460070
-
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
-
CrossRef PubMed
-
West, A. B., Moore, D. J., Biskup, S., Bugayenko, A., Smith, W. W., Ross, C. A., Dawson, V. L. and Dawson, T. M. (2005) Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc. Natl. Acad. Sci. U.S.A. 102, 16842-16847 CrossRef PubMed
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 16842-16847
-
-
West, A.B.1
Moore, D.J.2
Biskup, S.3
Bugayenko, A.4
Smith, W.W.5
Ross, C.A.6
Dawson, V.L.7
Dawson, T.M.8
-
10
-
-
84872515516
-
Kinase drug discovery: What's next in the field?
-
CrossRef PubMed
-
Cohen, P. and Alessi, D. R. (2013) Kinase drug discovery: what's next in the field? ACS Chem. Biol. 8, 96-104 CrossRef PubMed
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 96-104
-
-
Cohen, P.1
Alessi, D.R.2
-
11
-
-
40349101849
-
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
-
CrossRef PubMed
-
Deng, J., Lewis, P. A., Greggio, E., Sluch, E., Beilina, A. and Cookson, M. R. (2008) Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proc. Natl. Acad. Sci. U.S.A. 105, 1499-1504 CrossRef PubMed
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 1499-1504
-
-
Deng, J.1
Lewis, P.A.2
Greggio, E.3
Sluch, E.4
Beilina, A.5
Cookson, M.R.6
-
12
-
-
49949099269
-
Structure of the Roc-COR domain tandem of C. Tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase
-
CrossRef PubMed
-
Gotthardt, K., Weyand, M., Kortholt, A., van Haastert, P. J. and Wittinghofer, A. (2008) Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO J. 27, 2239-2249 CrossRef PubMed
-
(2008)
EMBO J.
, vol.27
, pp. 2239-2249
-
-
Gotthardt, K.1
Weyand, M.2
Kortholt, A.3
Van Haastert, P.J.4
Wittinghofer, A.5
-
13
-
-
84896522656
-
Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain
-
CrossRef PubMed
-
Liao, J., Wu, C. X., Burlak, C., Zhang, S., Sahm, H., Wang, M., Zhang, Z. Y., Vogel, K. W., Federici, M., Riddle, S. M. et al. (2014) Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain. Proc. Natl. Acad. Sci. U.S.A. 111, 4055-4060 CrossRef PubMed
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. 4055-4060
-
-
Liao, J.1
Wu, C.X.2
Burlak, C.3
Zhang, S.4
Sahm, H.5
Wang, M.6
Zhang, Z.Y.7
Vogel, K.W.8
Federici, M.9
Riddle, S.M.10
-
14
-
-
34548604567
-
The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an
-
authentic GTPase that stimulates kinase activity. CrossRef PubMed
-
Guo, L., Gandhi, P. N., Wang, W., Petersen, R. B., Wilson-Delfosse, A. L. and Chen, S. G. (2007) The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. Exp. Cell Res. 313, 3658-3670 CrossRef PubMed
-
(2007)
Exp. Cell Res.
, vol.313
, pp. 3658-3670
-
-
Guo, L.1
Gandhi, P.N.2
Wang, W.3
Petersen, R.B.4
Wilson-Delfosse, A.L.5
Chen, S.G.6
-
15
-
-
33846818834
-
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
-
CrossRef PubMed
-
Ito, G., Okai, T., Fujino, G., Takeda, K., Ichijo, H., Katada, T. and Iwatsubo, T. (2007) GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease. Biochemistry 46, 1380-1388 CrossRef PubMed
-
(2007)
Biochemistry
, vol.46
, pp. 1380-1388
-
-
Ito, G.1
Okai, T.2
Fujino, G.3
Takeda, K.4
Ichijo, H.5
Katada, T.6
Iwatsubo, T.7
-
16
-
-
34247468302
-
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
-
CrossRef PubMed
-
Lewis, P. A., Greggio, E., Beilina, A., Jain, S., Baker, A. and Cookson, M. R. (2007) The R1441C mutation of LRRK2 disrupts GTP hydrolysis. Biochem. Biophys. Res. Commun. 357, 668-671 CrossRef PubMed
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.357
, pp. 668-671
-
-
Lewis, P.A.1
Greggio, E.2
Beilina, A.3
Jain, S.4
Baker, A.5
Cookson, M.R.6
-
17
-
-
34548621385
-
Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants
-
CrossRef PubMed
-
Li, X., Tan, Y. C., Poulose, S., Olanow, C. W., Huang, X. Y. and Yue, Z. (2007) Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J. Neurochem. 103, 238-247 CrossRef PubMed
-
(2007)
J. Neurochem.
, vol.103
, pp. 238-247
-
-
Li, X.1
Tan, Y.C.2
Poulose, S.3
Olanow, C.W.4
Huang, X.Y.5
Yue, Z.6
-
18
-
-
33846562487
-
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
-
CrossRef PubMed
-
West, A. B., Moore, D. J., Choi, C., Andrabi, S. A., Li, X., Dikeman, D., Biskup, S., Zhang, Z., Lim, K. L., Dawson, V. L. and Dawson, T. M. (2007) Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Hum. Mol. Genet. 16, 223-232 CrossRef PubMed
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 223-232
-
-
West, A.B.1
Moore, D.J.2
Choi, C.3
Andrabi, S.A.4
Li, X.5
Dikeman, D.6
Biskup, S.7
Zhang, Z.8
Lim, K.L.9
Dawson, V.L.10
Dawson, T.M.11
-
19
-
-
0029991350
-
Transfecting mammalian cells: Optimization of critical parameters affecting calcium-phosphate precipitate formation
-
CrossRef PubMed
-
Jordan, M., Schallhorn, A. and Wurm, F. M. (1996) Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res. 24, 596-601 CrossRef PubMed
-
(1996)
Nucleic Acids Res.
, vol.24
, pp. 596-601
-
-
Jordan, M.1
Schallhorn, A.2
Wurm, F.M.3
-
20
-
-
84862996255
-
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations
-
CrossRef PubMed
-
Gilsbach, B. K., Ho, F. Y., Vetter, I. R., van Haastert, P. J., Wittinghofer, A. and Kortholt, A. (2012) Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc. Natl. Acad. Sci. U.S.A. 109, 10322-10327 CrossRef PubMed
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 10322-10327
-
-
Gilsbach, B.K.1
Ho, F.Y.2
Vetter, I.R.3
Van Haastert, P.J.4
Wittinghofer, A.5
Kortholt, A.6
-
21
-
-
0035834388
-
The guanine nucleotide-binding switch in three dimensions
-
CrossRef PubMed
-
Vetter, I. R. and Wittinghofer, A. (2001) The guanine nucleotide-binding switch in three dimensions. Science 294, 1299-1304 CrossRef PubMed
-
(2001)
Science
, vol.294
, pp. 1299-1304
-
-
Vetter, I.R.1
Wittinghofer, A.2
-
22
-
-
77749255337
-
Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2, characterization of the kinase and GTPase activities
-
CrossRef PubMed
-
Liu, M., Dobson, B., Glicksman, M. A., Yue, Z. and Stein, R. L. (2010) Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2, characterization of the kinase and GTPase activities. Biochemistry 49, 2008-2017 CrossRef PubMed
-
(2010)
Biochemistry
, vol.49
, pp. 2008-2017
-
-
Liu, M.1
Dobson, B.2
Glicksman, M.A.3
Yue, Z.4
Stein, R.L.5
-
23
-
-
0026026818
-
The GTPase superfamily: Conserved structure and molecular mechanism
-
CrossRef PubMed
-
Bourne, H. R., Sanders, D. A. and Mccormick, F. (1991) The GTPase superfamily: conserved structure and molecular mechanism. Nature 349, 117-127 CrossRef PubMed
-
(1991)
Nature
, vol.349
, pp. 117-127
-
-
Bourne, H.R.1
Sanders, D.A.2
Mccormick, F.3
-
24
-
-
47749114984
-
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
-
CrossRef PubMed
-
Greggio, E., Zambrano, I., Kaganovich, A., Beilina, A., Taymans, J. M., Daniëls, V., Lewis, P., Jain, S., Ding, J., Syed, A. et al. (2008) The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. J. Biol. Chem. 283, 16906-16914 CrossRef PubMed
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16906-16914
-
-
Greggio, E.1
Zambrano, I.2
Kaganovich, A.3
Beilina, A.4
Taymans, J.M.5
Daniëls, V.6
Lewis, P.7
Jain, S.8
Ding, J.9
Syed, A.10
-
25
-
-
73649120624
-
Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization
-
CrossRef PubMed
-
Sen, S., Webber, P. J. and West, A. B. (2009) Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization. J. Biol. Chem. 284, 36346-36356 CrossRef PubMed
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 36346-36356
-
-
Sen, S.1
Webber, P.J.2
West, A.B.3
-
26
-
-
84885943281
-
LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and tropomyosin 4
-
CrossRef PubMed
-
Häbig, K., Gellhaar, S., Heim, B., Djuric, V., Giesert, F., Wurst, W., Walter, C., Hentrich, T., Riess, O. and Bonin, M. (2013) LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and tropomyosin 4. Biochim. Biophys. Acta 1832, 2352-2367 CrossRef PubMed
-
(2013)
Biochim. Biophys. Acta
, vol.1832
, pp. 2352-2367
-
-
Häbig, K.1
Gellhaar, S.2
Heim, B.3
Djuric, V.4
Giesert, F.5
Wurst, W.6
Walter, C.7
Hentrich, T.8
Riess, O.9
Bonin, M.10
-
27
-
-
78149446290
-
ARHGEF7 (innodatabeta -PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
-
CrossRef PubMed
-
Haebig, K., Gloeckner, C. J., Miralles, M. G., Gillardon, F., Schulte, C., Riess, O., Ueffing, M., Biskup, S. and Bonin, M. (2010) ARHGEF7 (innodatabeta -PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS ONE 5, e13762 CrossRef PubMed
-
(2010)
PLoS ONE
, vol.5
, pp. e13762
-
-
Haebig, K.1
Gloeckner, C.J.2
Miralles, M.G.3
Gillardon, F.4
Schulte, C.5
Riess, O.6
Ueffing, M.7
Biskup, S.8
Bonin, M.9
-
28
-
-
84858050446
-
ArfGAP1 is a GTPase activating protein for LRRK2, reciprocal regulation of ArfGAP1 by LRRK2
-
CrossRef PubMed
-
Xiong, Y., Yuan, C., Chen, R., Dawson, T. M. and Dawson, V. L. (2012) ArfGAP1 is a GTPase activating protein for LRRK2, reciprocal regulation of ArfGAP1 by LRRK2. J. Neurosci. 32, 3877-3886 CrossRef PubMed
-
(2012)
J. Neurosci.
, vol.32
, pp. 3877-3886
-
-
Xiong, Y.1
Yuan, C.2
Chen, R.3
Dawson, T.M.4
Dawson, V.L.5
-
29
-
-
84865583070
-
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers
-
CrossRef PubMed
-
Civiero, L., Vancraenenbroeck, R., Belluzzi, E., Beilina, A., Lobbestael, E., Reyniers, L., Gao, F., Micetic, I., De Maeyer, M., Bubacco, L. et al. (2012) Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. PLoS ONE 7, e43472 CrossRef PubMed
-
(2012)
PLoS ONE
, vol.7
, pp. e43472
-
-
Civiero, L.1
Vancraenenbroeck, R.2
Belluzzi, E.3
Beilina, A.4
Lobbestael, E.5
Reyniers, L.6
Gao, F.7
Micetic, I.8
De Maeyer, M.9
Bubacco, L.10
-
30
-
-
84861870829
-
Number and brightness analysis of LRRK2 oligomerization in live cells
-
CrossRef PubMed
-
James, N. G., Digman, M. A., Gratton, E., Barylko, B., Ding, X., Albanesi, J. P., Goldberg, M. S. and Jameson, D. M. (2012) Number and brightness analysis of LRRK2 oligomerization in live cells. Biophys. J. 102, L41-L43 CrossRef PubMed
-
(2012)
Biophys. J.
, vol.102
, pp. L41-L43
-
-
James, N.G.1
Digman, M.A.2
Gratton, E.3
Barylko, B.4
Ding, X.5
Albanesi, J.P.6
Goldberg, M.S.7
Jameson, D.M.8
-
31
-
-
67349250817
-
It takes two to tango: Regulation of G proteins by dimerization
-
CrossRef PubMed
-
Gasper, R., Meyer, S., Gotthardt, K., Sirajuddin, M. and Wittinghofer, A. (2009) It takes two to tango: regulation of G proteins by dimerization. Nat. Rev. Mol. Cell Biol. 10, 423-429 CrossRef PubMed
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 423-429
-
-
Gasper, R.1
Meyer, S.2
Gotthardt, K.3
Sirajuddin, M.4
Wittinghofer, A.5
|