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Volumn 465, Issue , 2015, Pages 139-147

Revisiting the Roco G-protein cycle

Author keywords

Dimerization; GAD; Guanosine 5 triphosphatase (gtpase); Leucine rich repeat kinase 2 (lrrk2); Parkinson's disease

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; LEUCINE RICH REPEAT KINASE 2; NUCLEOTIDE; ROCO PROTEIN; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; GUANOSINE DIPHOSPHATE; LRRK2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

EID: 84918508656     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20141095     Document Type: Article
Times cited : (29)

References (31)
  • 1
    • 66949152096 scopus 로고    scopus 로고
    • Parkinson's disease
    • CrossRef PubMed
    • Lees, A. J., Hardy, J. and Revesz, T. (2009) Parkinson's disease. Lancet 373, 2055-2066 CrossRef PubMed
    • (2009) Lancet , vol.373 , pp. 2055-2066
    • Lees, A.J.1    Hardy, J.2    Revesz, T.3
  • 5
    • 0345118282 scopus 로고    scopus 로고
    • Roc, a Ras/GTPase domain in complex proteins
    • CrossRef PubMed
    • Bosgraaf, L. and van Haastert, P. J. (2003) Roc, a Ras/GTPase domain in complex proteins. Biochim. Biophys. Acta 1643, 5-10 CrossRef PubMed
    • (2003) Biochim. Biophys. Acta , vol.1643 , pp. 5-10
    • Bosgraaf, L.1    Van Haastert, P.J.2
  • 6
    • 77953890085 scopus 로고    scopus 로고
    • Parkinson's disease: Insights from pathways
    • CrossRef PubMed
    • Cookson, M. R. and Bandmann, O. (2010) Parkinson's disease: insights from pathways. Hum. Mol. Genet. 19, R21-R27 CrossRef PubMed
    • (2010) Hum. Mol. Genet. , vol.19 , pp. R21-R27
    • Cookson, M.R.1    Bandmann, O.2
  • 8
    • 34548432121 scopus 로고    scopus 로고
    • Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation
    • CrossRef PubMed
    • Luzón-Toro, B., Rubio, d.l.T., Delgado, A., Pérez-Tur, J. and Hilfiker, S. (2007) Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation. Hum. Mol. Genet. 16, 2031-2039 CrossRef PubMed
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 2031-2039
    • Luzón-Toro, B.1    Rubio, D.L.T.2    Delgado, A.3    Pérez-Tur, J.4    Hilfiker, S.5
  • 10
    • 84872515516 scopus 로고    scopus 로고
    • Kinase drug discovery: What's next in the field?
    • CrossRef PubMed
    • Cohen, P. and Alessi, D. R. (2013) Kinase drug discovery: what's next in the field? ACS Chem. Biol. 8, 96-104 CrossRef PubMed
    • (2013) ACS Chem. Biol. , vol.8 , pp. 96-104
    • Cohen, P.1    Alessi, D.R.2
  • 11
    • 40349101849 scopus 로고    scopus 로고
    • Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
    • CrossRef PubMed
    • Deng, J., Lewis, P. A., Greggio, E., Sluch, E., Beilina, A. and Cookson, M. R. (2008) Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proc. Natl. Acad. Sci. U.S.A. 105, 1499-1504 CrossRef PubMed
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 1499-1504
    • Deng, J.1    Lewis, P.A.2    Greggio, E.3    Sluch, E.4    Beilina, A.5    Cookson, M.R.6
  • 12
    • 49949099269 scopus 로고    scopus 로고
    • Structure of the Roc-COR domain tandem of C. Tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase
    • CrossRef PubMed
    • Gotthardt, K., Weyand, M., Kortholt, A., van Haastert, P. J. and Wittinghofer, A. (2008) Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO J. 27, 2239-2249 CrossRef PubMed
    • (2008) EMBO J. , vol.27 , pp. 2239-2249
    • Gotthardt, K.1    Weyand, M.2    Kortholt, A.3    Van Haastert, P.J.4    Wittinghofer, A.5
  • 14
    • 34548604567 scopus 로고    scopus 로고
    • The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an
    • authentic GTPase that stimulates kinase activity. CrossRef PubMed
    • Guo, L., Gandhi, P. N., Wang, W., Petersen, R. B., Wilson-Delfosse, A. L. and Chen, S. G. (2007) The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. Exp. Cell Res. 313, 3658-3670 CrossRef PubMed
    • (2007) Exp. Cell Res. , vol.313 , pp. 3658-3670
    • Guo, L.1    Gandhi, P.N.2    Wang, W.3    Petersen, R.B.4    Wilson-Delfosse, A.L.5    Chen, S.G.6
  • 15
    • 33846818834 scopus 로고    scopus 로고
    • GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
    • CrossRef PubMed
    • Ito, G., Okai, T., Fujino, G., Takeda, K., Ichijo, H., Katada, T. and Iwatsubo, T. (2007) GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease. Biochemistry 46, 1380-1388 CrossRef PubMed
    • (2007) Biochemistry , vol.46 , pp. 1380-1388
    • Ito, G.1    Okai, T.2    Fujino, G.3    Takeda, K.4    Ichijo, H.5    Katada, T.6    Iwatsubo, T.7
  • 17
    • 34548621385 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants
    • CrossRef PubMed
    • Li, X., Tan, Y. C., Poulose, S., Olanow, C. W., Huang, X. Y. and Yue, Z. (2007) Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J. Neurochem. 103, 238-247 CrossRef PubMed
    • (2007) J. Neurochem. , vol.103 , pp. 238-247
    • Li, X.1    Tan, Y.C.2    Poulose, S.3    Olanow, C.W.4    Huang, X.Y.5    Yue, Z.6
  • 19
    • 0029991350 scopus 로고    scopus 로고
    • Transfecting mammalian cells: Optimization of critical parameters affecting calcium-phosphate precipitate formation
    • CrossRef PubMed
    • Jordan, M., Schallhorn, A. and Wurm, F. M. (1996) Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res. 24, 596-601 CrossRef PubMed
    • (1996) Nucleic Acids Res. , vol.24 , pp. 596-601
    • Jordan, M.1    Schallhorn, A.2    Wurm, F.M.3
  • 20
    • 84862996255 scopus 로고    scopus 로고
    • Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations
    • CrossRef PubMed
    • Gilsbach, B. K., Ho, F. Y., Vetter, I. R., van Haastert, P. J., Wittinghofer, A. and Kortholt, A. (2012) Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc. Natl. Acad. Sci. U.S.A. 109, 10322-10327 CrossRef PubMed
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 10322-10327
    • Gilsbach, B.K.1    Ho, F.Y.2    Vetter, I.R.3    Van Haastert, P.J.4    Wittinghofer, A.5    Kortholt, A.6
  • 21
    • 0035834388 scopus 로고    scopus 로고
    • The guanine nucleotide-binding switch in three dimensions
    • CrossRef PubMed
    • Vetter, I. R. and Wittinghofer, A. (2001) The guanine nucleotide-binding switch in three dimensions. Science 294, 1299-1304 CrossRef PubMed
    • (2001) Science , vol.294 , pp. 1299-1304
    • Vetter, I.R.1    Wittinghofer, A.2
  • 22
    • 77749255337 scopus 로고    scopus 로고
    • Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2, characterization of the kinase and GTPase activities
    • CrossRef PubMed
    • Liu, M., Dobson, B., Glicksman, M. A., Yue, Z. and Stein, R. L. (2010) Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2, characterization of the kinase and GTPase activities. Biochemistry 49, 2008-2017 CrossRef PubMed
    • (2010) Biochemistry , vol.49 , pp. 2008-2017
    • Liu, M.1    Dobson, B.2    Glicksman, M.A.3    Yue, Z.4    Stein, R.L.5
  • 23
    • 0026026818 scopus 로고
    • The GTPase superfamily: Conserved structure and molecular mechanism
    • CrossRef PubMed
    • Bourne, H. R., Sanders, D. A. and Mccormick, F. (1991) The GTPase superfamily: conserved structure and molecular mechanism. Nature 349, 117-127 CrossRef PubMed
    • (1991) Nature , vol.349 , pp. 117-127
    • Bourne, H.R.1    Sanders, D.A.2    Mccormick, F.3
  • 24
    • 47749114984 scopus 로고    scopus 로고
    • The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
    • CrossRef PubMed
    • Greggio, E., Zambrano, I., Kaganovich, A., Beilina, A., Taymans, J. M., Daniëls, V., Lewis, P., Jain, S., Ding, J., Syed, A. et al. (2008) The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. J. Biol. Chem. 283, 16906-16914 CrossRef PubMed
    • (2008) J. Biol. Chem. , vol.283 , pp. 16906-16914
    • Greggio, E.1    Zambrano, I.2    Kaganovich, A.3    Beilina, A.4    Taymans, J.M.5    Daniëls, V.6    Lewis, P.7    Jain, S.8    Ding, J.9    Syed, A.10
  • 25
    • 73649120624 scopus 로고    scopus 로고
    • Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization
    • CrossRef PubMed
    • Sen, S., Webber, P. J. and West, A. B. (2009) Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization. J. Biol. Chem. 284, 36346-36356 CrossRef PubMed
    • (2009) J. Biol. Chem. , vol.284 , pp. 36346-36356
    • Sen, S.1    Webber, P.J.2    West, A.B.3
  • 27
    • 78149446290 scopus 로고    scopus 로고
    • ARHGEF7 (innodatabeta -PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
    • CrossRef PubMed
    • Haebig, K., Gloeckner, C. J., Miralles, M. G., Gillardon, F., Schulte, C., Riess, O., Ueffing, M., Biskup, S. and Bonin, M. (2010) ARHGEF7 (innodatabeta -PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS ONE 5, e13762 CrossRef PubMed
    • (2010) PLoS ONE , vol.5 , pp. e13762
    • Haebig, K.1    Gloeckner, C.J.2    Miralles, M.G.3    Gillardon, F.4    Schulte, C.5    Riess, O.6    Ueffing, M.7    Biskup, S.8    Bonin, M.9
  • 28
    • 84858050446 scopus 로고    scopus 로고
    • ArfGAP1 is a GTPase activating protein for LRRK2, reciprocal regulation of ArfGAP1 by LRRK2
    • CrossRef PubMed
    • Xiong, Y., Yuan, C., Chen, R., Dawson, T. M. and Dawson, V. L. (2012) ArfGAP1 is a GTPase activating protein for LRRK2, reciprocal regulation of ArfGAP1 by LRRK2. J. Neurosci. 32, 3877-3886 CrossRef PubMed
    • (2012) J. Neurosci. , vol.32 , pp. 3877-3886
    • Xiong, Y.1    Yuan, C.2    Chen, R.3    Dawson, T.M.4    Dawson, V.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.