-
1
-
-
0027771804
-
A C. Elegans mutant that lives twice as long as wild type
-
Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. 1993. A C. Elegans mutant that lives twice as long as wild type. Nature 366:461-64
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
3
-
-
84878948560
-
Molecular chaperone functions in protein folding and proteostasis
-
Kim YE, Hipp MS, Bracher A, Hayer-HartlM, Hartl FU. 2013. Molecular chaperone functions in protein folding and proteostasis. Annu. Rev. Biochem. 82:323-55
-
(2013)
Annu. Rev. Biochem.
, vol.82
, pp. 323-355
-
-
Kim, Y.E.1
Hipp, M.S.2
Bracher, A.3
Hayer-Hartl, M.4
Hartl, F.U.5
-
4
-
-
84919764653
-
A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease
-
Brehme M, Voisine C, Rolland T, Wachi S, Soper JH, et al. 2014. A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative diseasE. Cell Rep. 9:1135-50
-
(2014)
Cell Rep.
, vol.9
, pp. 1135-1150
-
-
Brehme, M.1
Voisine, C.2
Rolland, T.3
Wachi, S.4
Soper, J.H.5
-
5
-
-
70349266064
-
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
-
Ben-Zvi A, Miller EA, Morimoto RI. 2009. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. PNAS 106:14914-19
-
(2009)
PNAS
, vol.106
, pp. 14914-14919
-
-
Ben-Zvi, A.1
Miller, E.A.2
Morimoto, R.I.3
-
6
-
-
77956362155
-
Protein homeostasis and aging in neurodegeneration
-
Douglas PM, Dillin A. 2010. Protein homeostasis and aging in neurodegeneration. J. Cell Biol. 190:719-29
-
(2010)
J. Cell Biol.
, vol.190
, pp. 719-729
-
-
Douglas, P.M.1
Dillin, A.2
-
7
-
-
84906794886
-
Proteostasis impairment in protein-misfolding and-aggregation diseases
-
Hipp MS, Park S-H, Hartl FU. 2014. Proteostasis impairment in protein-misfolding and-aggregation diseases. Trends Cell Biol. 24:506-14
-
(2014)
Trends Cell Biol.
, vol.24
, pp. 506-514
-
-
Hipp, M.S.1
Park, S.-H.2
Hartl, F.U.3
-
8
-
-
84941731816
-
Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments
-
Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, et al. 2015. Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments. EMBO J. 34:2334-49
-
(2015)
EMBO J.
, vol.34
, pp. 2334-2349
-
-
Kirstein, J.1
Morito, D.2
Kakihana, T.3
Sugihara, M.4
Minnen, A.5
-
9
-
-
78650963274
-
Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions
-
Olzscha H, Schermann SM, Woerner AC, Pinkert S, Hecht MH, et al. 2011. Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell 144:67-78
-
(2011)
Cell
, vol.144
, pp. 67-78
-
-
Olzscha, H.1
Schermann, S.M.2
Woerner, A.C.3
Pinkert, S.4
Hecht, M.H.5
-
10
-
-
84955098544
-
Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA
-
Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, et al. 2016. Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA. Science 351:173-76
-
(2016)
Science
, vol.351
, pp. 173-176
-
-
Woerner, A.C.1
Frottin, F.2
Hornburg, D.3
Feng, L.R.4
Meissner, F.5
-
12
-
-
79959463520
-
Regulation ofHSF1 function in the heat stress response: Implications in aging and disease
-
Anckar J, Sistonen L. 2011. Regulation ofHSF1 function in the heat stress response: implications in aging and disease. Annu. Rev. Biochem. 80:1089-115
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 1089-1115
-
-
Anckar, J.1
Sistonen, L.2
-
13
-
-
0038701745
-
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
-
Hsu AL, Murphy CT, Kenyon C. 2003. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300:1142-45
-
(2003)
Science
, vol.300
, pp. 1142-1145
-
-
Hsu, A.L.1
Murphy, C.T.2
Kenyon, C.3
-
14
-
-
84908077843
-
HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span
-
Baird NA, Douglas PM, Simic MS, Grant AR, Moresco JJ, et al. 2014. HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span. Science 346:360-63
-
(2014)
Science
, vol.346
, pp. 360-363
-
-
Baird, N.A.1
Douglas, P.M.2
Simic, M.S.3
Grant, A.R.4
Moresco, J.J.5
-
15
-
-
84928963751
-
Widespread proteome remodeling and aggregation in aging C
-
Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, et al. 2015. Widespread proteome remodeling and aggregation in aging C. Elegans. Cell 161:919-32
-
(2015)
Elegans. Cell
, vol.161
, pp. 919-932
-
-
Walther, D.M.1
Kasturi, P.2
Zheng, M.3
Pinkert, S.4
Vecchi, G.5
-
16
-
-
84939493473
-
Repression of the heat shock response is a programmed event at the onset of reproduction
-
Labbadia J, Morimoto RI. 2015. Repression of the heat shock response is a programmed event at the onset of reproduction. Mol. Cell 59:639-50
-
(2015)
Mol. Cell
, vol.59
, pp. 639-650
-
-
Labbadia, J.1
Morimoto, R.I.2
-
17
-
-
78650510609
-
MTOR: From growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A, Sabatini DM. 2011. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12:21-35
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
18
-
-
82255173966
-
The unfolded protein response: From stress pathway to homeostatic regulation
-
Walter P, Ron D. 2011. The unfolded protein response: from stress pathway to homeostatic regulation. Science 334:1081-86
-
(2011)
Science
, vol.334
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
19
-
-
84941747116
-
UPR (mt)-mediated cytoprotection and organismal aging
-
Schulz AM, HaynesCM. 2015. UPR(mt)-mediated cytoprotection and organismal aging. Biochim. Biophys. Acta 1847:1448-56
-
(2015)
Biochim. Biophys. Acta
, vol.1847
, pp. 1448-1456
-
-
Schulz, A.M.1
Haynes, C.M.2
-
20
-
-
0037147103
-
Rates of behavior and aging specified by mitochondrial function during development
-
Dillin A, Hsu AL, Arantes-Oliveira N, Lehrer-Graiwer J, Hsin H, et al. 2002. Rates of behavior and aging specified by mitochondrial function during development. Science 298:2398-401
-
(2002)
Science
, vol.298
, pp. 2398-2401
-
-
Dillin, A.1
Hsu, A.L.2
Arantes-Oliveira, N.3
Lehrer-Graiwer, J.4
Hsin, H.5
-
22
-
-
84925852614
-
Promoting health and longevity through diet: From model organisms to humans
-
Fontana L, Partridge L. 2015. Promoting health and longevity through diet: from model organisms to humans. Cell 161:106-18
-
(2015)
Cell
, vol.161
, pp. 106-118
-
-
Fontana, L.1
Partridge, L.2
|