메뉴 건너뛰기




Volumn 36, Issue 4, 2016, Pages 641-671

COX-1 Inhibitors: Beyond Structure Toward Therapy

Author keywords

COX 1 inhibitors; docking studies; natural compounds and dietary phytochemicals; neuroinflammation; ovarian cancer

Indexed keywords

BENZAMIDE DERIVATIVE; CANNABINOID; CARBOXYLIC ACID; CURCUMINOID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; FLAVONOID; ISOXAZOLE DERIVATIVE; PLANT EXTRACT; PYRAZOLE DERIVATIVE; RUMEX NEPALENSIS EXTRACT; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 84974678249     PISSN: 01986325     EISSN: 10981128     Source Type: Journal    
DOI: 10.1002/med.21389     Document Type: Review
Times cited : (55)

References (64)
  • 1
    • 78650657838 scopus 로고    scopus 로고
    • Selective COX-1 inhibition: A therapeutic target to be reconsidered
    • Perrone MG, Scilimati A, Simone L, Vitale P. Selective COX-1 inhibition: A therapeutic target to be reconsidered. Curr Med Chem 2010;17(32):3769–3805.
    • (2010) Curr Med Chem , vol.17 , Issue.32 , pp. 3769-3805
    • Perrone, M.G.1    Scilimati, A.2    Simone, L.3    Vitale, P.4
  • 2
    • 84924696954 scopus 로고    scopus 로고
    • General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model
    • Perrone MG, Vitale P, Panella A, Fortuna CG, Scilimati A. General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model. Eur J Med Chem 2015;94:252–264.
    • (2015) Eur J Med Chem , vol.94 , pp. 252-264
    • Perrone, M.G.1    Vitale, P.2    Panella, A.3    Fortuna, C.G.4    Scilimati, A.5
  • 4
    • 84921415434 scopus 로고    scopus 로고
    • The effect of COX-2-selective meloxicam on the myocardial, vascular and renal risks: A systematic review
    • Asghar W, Jamali F. The effect of COX-2-selective meloxicam on the myocardial, vascular and renal risks: A systematic review. Inflammopharmacology 2015;23(1):1–16.
    • (2015) Inflammopharmacology , vol.23 , Issue.1 , pp. 1-16
    • Asghar, W.1    Jamali, F.2
  • 5
    • 84922519182 scopus 로고    scopus 로고
    • Cyclooxygenase inhibitors: From pharmacology to clinical read-outs
    • Patrignani P, Patrono C. Cyclooxygenase inhibitors: From pharmacology to clinical read-outs. Biochim Biophys Acta 2015;1851(4):422–432.
    • (2015) Biochim Biophys Acta , vol.1851 , Issue.4 , pp. 422-432
    • Patrignani, P.1    Patrono, C.2
  • 7
    • 0033565252 scopus 로고    scopus 로고
    • Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process
    • Reddy BS, Kawamori T, Lubet RA, Steele VE, Kelloff GJ, Rao CV. Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process. Cancer Res 1999;59(14):3387–3391.
    • (1999) Cancer Res , vol.59 , Issue.14 , pp. 3387-3391
    • Reddy, B.S.1    Kawamori, T.2    Lubet, R.A.3    Steele, V.E.4    Kelloff, G.J.5    Rao, C.V.6
  • 10
    • 84953775020 scopus 로고    scopus 로고
    • Update on SAR studies toward new COX-1 selective inhibitors
    • Vitale P, Scilimati A, Perrone MG. Update on SAR studies toward new COX-1 selective inhibitors. Curr Med Chem 2015;22(37):4271–4292.
    • (2015) Curr Med Chem , vol.22 , Issue.37 , pp. 4271-4292
    • Vitale, P.1    Scilimati, A.2    Perrone, M.G.3
  • 11
    • 0031664462 scopus 로고    scopus 로고
    • Analgesic effect of mofezolac, a non-steroidal anti-inflammatory drug, against phenylquinone-induced acute pain in mice A new antiinflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
    • Goto K, Ochi H, Yasunaga Y, Matsuyuki H, Imayoshi T, Kusuhara H, Okumoto T. Analgesic effect of mofezolac, a non-steroidal anti-inflammatory drug, against phenylquinone-induced acute pain in mice A new antiinflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins Other Lipid Mediat 1998;56(4):245–254.
    • (1998) Prostaglandins Other Lipid Mediat , vol.56 , Issue.4 , pp. 245-254
    • Goto, K.1    Ochi, H.2    Yasunaga, Y.3    Matsuyuki, H.4    Imayoshi, T.5    Kusuhara, H.6    Okumoto, T.7
  • 12
    • 4544371096 scopus 로고    scopus 로고
    • Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: Reversal cyclooxygenase-2 selectivity by sulfonamide group removal
    • Di Nunno L, Vitale P, Scilimati A, Tacconelli S, Patrignani P. Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: Reversal cyclooxygenase-2 selectivity by sulfonamide group removal. J Med Chem 2004;47(20):4881–4890.
    • (2004) J Med Chem , vol.47 , Issue.20 , pp. 4881-4890
    • Di Nunno, L.1    Vitale, P.2    Scilimati, A.3    Tacconelli, S.4    Patrignani, P.5
  • 14
  • 17
    • 43049148000 scopus 로고    scopus 로고
    • Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. Design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor
    • Kakuta H, Zheng X, Oda H, Harada S, Sugimoto Y, Sasaki K, Tai A. Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. Design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. J Med Chem 2008;51(8):2400–2411.
    • (2008) J Med Chem , vol.51 , Issue.8 , pp. 2400-2411
    • Kakuta, H.1    Zheng, X.2    Oda, H.3    Harada, S.4    Sugimoto, Y.5    Sasaki, K.6    Tai, A.7
  • 19
    • 79952265579 scopus 로고    scopus 로고
    • Significance and creation of novel cyclooxygenase-1 (COX-1) selective inhibitors
    • Fukai R, Zheng X, Motoshima K, Kakuta H. Significance and creation of novel cyclooxygenase-1 (COX-1) selective inhibitors. J Pharm Soc Jpn 2011;131(3):347–351.
    • (2011) J Pharm Soc Jpn , vol.131 , Issue.3 , pp. 347-351
    • Fukai, R.1    Zheng, X.2    Motoshima, K.3    Kakuta, H.4
  • 20
    • 78650511272 scopus 로고    scopus 로고
    • Design of novel N-phenylnicotinamides as selective cyclooxygenase-1 inhibitors
    • Shi L, Li ZL, Yang Y, Zhu ZW, Zhu HL. Design of novel N-phenylnicotinamides as selective cyclooxygenase-1 inhibitors. Bioorg Med Chem Lett 2011;21(1):121–124.
    • (2011) Bioorg Med Chem Lett , vol.21 , Issue.1 , pp. 121-124
    • Shi, L.1    Li, Z.L.2    Yang, Y.3    Zhu, Z.W.4    Zhu, H.L.5
  • 23
    • 84907854234 scopus 로고    scopus 로고
    • Discovery of potential and selective COX-1 inhibitory leads using pharmacophore modelling, in silico screening and in vitro evaluation
    • Balaji B, Hariharan S, Shah DB, Ramanathan M. Discovery of potential and selective COX-1 inhibitory leads using pharmacophore modelling, in silico screening and in vitro evaluation. Eur J Med Chem 2014;86:469–480.
    • (2014) Eur J Med Chem , vol.86 , pp. 469-480
    • Balaji, B.1    Hariharan, S.2    Shah, D.B.3    Ramanathan, M.4
  • 24
    • 84899858172 scopus 로고    scopus 로고
    • Functionalized magnetic nanoparticles coupled with mass spectrometry for screening and identification of cyclooxygenase-1 inhibitors from natural products
    • Zhang Y, Shi S, Chen X, Peng M. Functionalized magnetic nanoparticles coupled with mass spectrometry for screening and identification of cyclooxygenase-1 inhibitors from natural products. J Chrom B Anal Technol Biomed Life Sci 2014;960:126–132.
    • (2014) J Chrom B Anal Technol Biomed Life Sci , vol.960 , pp. 126-132
    • Zhang, Y.1    Shi, S.2    Chen, X.3    Peng, M.4
  • 26
    • 79952362649 scopus 로고    scopus 로고
    • Anti-inflammatory, cyclooxygenase inhibitory and antioxidant activities of standardized extracts of Tridax procumbens L
    • Jachak SM, Gautam R, Selvam C, Madhan H, Srivastava A, Khan T. Anti-inflammatory, cyclooxygenase inhibitory and antioxidant activities of standardized extracts of Tridax procumbens L. Fitoterapia 2011;82(2):173–177.
    • (2011) Fitoterapia , vol.82 , Issue.2 , pp. 173-177
    • Jachak, S.M.1    Gautam, R.2    Selvam, C.3    Madhan, H.4    Srivastava, A.5    Khan, T.6
  • 27
    • 84901596593 scopus 로고    scopus 로고
    • Nectandra amazonum-derived flavonoids as COX-1 inhibitors: In vitro and docking studies
    • Valdés-Barrera ID, Cuca-Suarez LE, Coy-Barrera ED. Nectandra amazonum-derived flavonoids as COX-1 inhibitors: In vitro and docking studies. Nat Prod Commun 2014;9(5):649–652.
    • (2014) Nat Prod Commun , vol.9 , Issue.5 , pp. 649-652
    • Valdés-Barrera, I.D.1    Cuca-Suarez, L.E.2    Coy-Barrera, E.D.3
  • 28
    • 84928350833 scopus 로고    scopus 로고
    • Antibacterial and COX-1 inhibitory effect of medicinal plants from the Pamir Mountains, Afghanistan
    • Jeppesen AS, Soelberg J, Jäger A. Antibacterial and COX-1 inhibitory effect of medicinal plants from the Pamir Mountains, Afghanistan. Plants 2012;1:74–81.
    • (2012) Plants , vol.1 , pp. 74-81
    • Jeppesen, A.S.1    Soelberg, J.2    Jäger, A.3
  • 30
    • 79955646963 scopus 로고    scopus 로고
    • Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids isolated from Cannabis sativa
    • Ruhaak LR, Felth J, Karlsson PC, Rafter JJ, Verpoorte R, Bohlin L. Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids isolated from Cannabis sativa. Biol Pharm Bull 2011;34(5):774–778.
    • (2011) Biol Pharm Bull , vol.34 , Issue.5 , pp. 774-778
    • Ruhaak, L.R.1    Felth, J.2    Karlsson, P.C.3    Rafter, J.J.4    Verpoorte, R.5    Bohlin, L.6
  • 31
    • 0034721794 scopus 로고    scopus 로고
    • Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2
    • Kozak KR, Rowlinson SW, Marnett LJ. Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2. J Biol Chem 2000;275(43):33744–33749.
    • (2000) J Biol Chem , vol.275 , Issue.43 , pp. 33744-33749
    • Kozak, K.R.1    Rowlinson, S.W.2    Marnett, L.J.3
  • 32
    • 0030611859 scopus 로고    scopus 로고
    • Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2
    • Yu M, Ives D, Ramesha CS. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. J Biol Chem 1997;272(34):21181–21186.
    • (1997) J Biol Chem , vol.272 , Issue.34 , pp. 21181-21186
    • Yu, M.1    Ives, D.2    Ramesha, C.S.3
  • 33
    • 50049113509 scopus 로고    scopus 로고
    • Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis
    • Takeda S, Misawa K, Yamamoto I, Watanabe K. Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis. Drug Metab Dispos 2008;36(9):1917–1921.
    • (2008) Drug Metab Dispos , vol.36 , Issue.9 , pp. 1917-1921
    • Takeda, S.1    Misawa, K.2    Yamamoto, I.3    Watanabe, K.4
  • 34
    • 84870685440 scopus 로고    scopus 로고
    • Platelet-associated angiogenesis evaulating factors: A pharmacological perspective
    • Radziwon-Balicka A, Moncada de la Rosa C, Jurasz P. Platelet-associated angiogenesis evaulating factors: A pharmacological perspective. Can J Physiol Pharmacol 2012;90(6):679–688.
    • (2012) Can J Physiol Pharmacol , vol.90 , Issue.6 , pp. 679-688
    • Radziwon-Balicka, A.1    Moncada de la Rosa, C.2    Jurasz, P.3
  • 36
    • 84882619034 scopus 로고    scopus 로고
    • Targeting the tumor microenvironment: From understanding pathways to effective clinical trials
    • Fang H, Declerck YA. Targeting the tumor microenvironment: From understanding pathways to effective clinical trials. Cancer Res 2013;73(16):4965–4977.
    • (2013) Cancer Res , vol.73 , Issue.16 , pp. 4965-4977
    • Fang, H.1    Declerck, Y.A.2
  • 37
    • 77956503727 scopus 로고    scopus 로고
    • Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres
    • Bar EE, Lin A, Mahairaki V, Matsui W, Eberhart CG. Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres. Am J Pathol 2010;177(3):1491–1502.
    • (2010) Am J Pathol , vol.177 , Issue.3 , pp. 1491-1502
    • Bar, E.E.1    Lin, A.2    Mahairaki, V.3    Matsui, W.4    Eberhart, C.G.5
  • 38
    • 84870941135 scopus 로고    scopus 로고
    • Hypoxia-regulated target genes implicated in tumor metastasis
    • Tsai YP, Wu KJ. Hypoxia-regulated target genes implicated in tumor metastasis. J Biomed Sci 2012;14(19):102
    • (2012) J Biomed Sci , vol.14 , Issue.19 , pp. 102
    • Tsai, Y.P.1    Wu, K.J.2
  • 39
    • 84855999133 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1a (HIF-1a) expression by interleukin-1b (IL-1b), insulin-like growth factors I (IGF-I) and II (IGF-II) in human osteoarthritic chondrocytes
    • Rossi Sartori-Cintra A, Sampaia de Mara C, Argolo DL, Bellini Coimbra I. Regulation of hypoxia-inducible factor-1a (HIF-1a) expression by interleukin-1b (IL-1b), insulin-like growth factors I (IGF-I) and II (IGF-II) in human osteoarthritic chondrocytes. Clinics (Sao Paulo) 2012;67(1):35–40.
    • (2012) Clinics (Sao Paulo) , vol.67 , Issue.1 , pp. 35-40
    • Rossi Sartori-Cintra, A.1    Sampaia de Mara, C.2    Argolo, D.L.3    Bellini Coimbra, I.4
  • 40
    • 84863010982 scopus 로고    scopus 로고
    • Anti-neoplastic action of aspirin against a T-cell lymphoma involves an alteration in the tumour microenvironment and regulation of tumour cell survival
    • Kumar A, Vishvakarma NK, Tyagi A, Bharti AC, Singh SM. Anti-neoplastic action of aspirin against a T-cell lymphoma involves an alteration in the tumour microenvironment and regulation of tumour cell survival. Biosci Rep 2012;32(1):91–104.
    • (2012) Biosci Rep , vol.32 , Issue.1 , pp. 91-104
    • Kumar, A.1    Vishvakarma, N.K.2    Tyagi, A.3    Bharti, A.C.4    Singh, S.M.5
  • 41
    • 84902789629 scopus 로고    scopus 로고
    • Aspirin may modify tumor microenvironment via antiplatelet effect
    • Su BB, Chen JH, Shi H, Chen QQ, Wan J. Aspirin may modify tumor microenvironment via antiplatelet effect. Med Hypotheses 2014;83:148–150.
    • (2014) Med Hypotheses , vol.83 , pp. 148-150
    • Su, B.B.1    Chen, J.H.2    Shi, H.3    Chen, Q.Q.4    Wan, J.5
  • 43
    • 81255205399 scopus 로고    scopus 로고
    • Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
    • Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 2011;20(5):576–590.
    • (2011) Cancer Cell , vol.20 , Issue.5 , pp. 576-590
    • Labelle, M.1    Begum, S.2    Hynes, R.O.3
  • 44
    • 79957487931 scopus 로고    scopus 로고
    • Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    • Bao B, Wang Z, Ali S, Kong D, Li Y, Ahmad A, Banerjee S, Azmi AS, Miele L, Sarkar FH. Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett 2011;307(1):26–36.
    • (2011) Cancer Lett , vol.307 , Issue.1 , pp. 26-36
    • Bao, B.1    Wang, Z.2    Ali, S.3    Kong, D.4    Li, Y.5    Ahmad, A.6    Banerjee, S.7    Azmi, A.S.8    Miele, L.9    Sarkar, F.H.10
  • 46
    • 84925535784 scopus 로고    scopus 로고
    • Aspirin inhibit platelet-induced epithelial-to-mesenchymal transition of circulating tumor cells
    • Lou XL, Deng J, Deng H, Ting Y, Zhou L, Liu YH, Hu JP, Huang XF, Qi XQ. Aspirin inhibit platelet-induced epithelial-to-mesenchymal transition of circulating tumor cells. Biomed Rep 2014;2(3):331–334.
    • (2014) Biomed Rep , vol.2 , Issue.3 , pp. 331-334
    • Lou, X.L.1    Deng, J.2    Deng, H.3    Ting, Y.4    Zhou, L.5    Liu, Y.H.6    Hu, J.P.7    Huang, X.F.8    Qi, X.Q.9
  • 50
    • 84880750089 scopus 로고    scopus 로고
    • Selective cyclooxygenase inhibitors increase paclitaxel sensitivity in taxane-resistant ovarian cancer by suppressing P-glycoprotein expression
    • Lee JP, Hahn HS, Hwang SJ, Choi JY, Park JS, Lee IH, Kim TJ. Selective cyclooxygenase inhibitors increase paclitaxel sensitivity in taxane-resistant ovarian cancer by suppressing P-glycoprotein expression. J Gynecol Oncol 2013;24(3):273–279.
    • (2013) J Gynecol Oncol , vol.24 , Issue.3 , pp. 273-279
    • Lee, J.P.1    Hahn, H.S.2    Hwang, S.J.3    Choi, J.Y.4    Park, J.S.5    Lee, I.H.6    Kim, T.J.7
  • 51
    • 0032725481 scopus 로고    scopus 로고
    • Cyclooxygenase-1 in human Alzheimer and control brain: Quantitative analysis of expression by microglia and CA3 hippocampal neurons
    • Yermakova AV, Rollins J, Callahan LM, Rogers J, O'Banion MK. Cyclooxygenase-1 in human Alzheimer and control brain: Quantitative analysis of expression by microglia and CA3 hippocampal neurons. J Neuropathol Exp Neurol 1999;58(11):1135–1146.
    • (1999) J Neuropathol Exp Neurol , vol.58 , Issue.11 , pp. 1135-1146
    • Yermakova, A.V.1    Rollins, J.2    Callahan, L.M.3    Rogers, J.4    O'Banion, M.K.5
  • 52
    • 34248180111 scopus 로고    scopus 로고
    • Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging
    • Aïd S, Bosetti F. Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging. Brain Res Bull 2007;73(1–3):108–113.
    • (2007) Brain Res Bull , vol.73 , Issue.1-3 , pp. 108-113
    • Aïd, S.1    Bosetti, F.2
  • 54
    • 62949176283 scopus 로고    scopus 로고
    • The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: Implications for translational research
    • Choi SH, Aid S, Bosetti F. The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: Implications for translational research. Trends Pharmacol Sci 2009;30:174–181.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 174-181
    • Choi, S.H.1    Aid, S.2    Bosetti, F.3
  • 55
    • 43249109884 scopus 로고    scopus 로고
    • Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury
    • Choi SH, Langenbach R, Bosetti F. Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury. FASEB J 2008;22:1491–501.
    • (2008) FASEB J , vol.22 , pp. 1491-1501
    • Choi, S.H.1    Langenbach, R.2    Bosetti, F.3
  • 57
    • 77957127862 scopus 로고    scopus 로고
    • Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain
    • Choi SH, Aid S, Choi U, Bosetti F. Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain. Pharmacogenomics J 2010;10:448–457.
    • (2010) Pharmacogenomics J , vol.10 , pp. 448-457
    • Choi, S.H.1    Aid, S.2    Choi, U.3    Bosetti, F.4
  • 58
    • 79961125036 scopus 로고    scopus 로고
    • Cyclooxygenase-1 is involved in the inhibition of hippocampal neurogenesis after lipopolysaccharide-induced neuroinflammation
    • Russo I, Amornphimoltham P, Weigert R, Barlati S, Bosetti F. Cyclooxygenase-1 is involved in the inhibition of hippocampal neurogenesis after lipopolysaccharide-induced neuroinflammation. Cell Cycle 2011;10:2568–2573.
    • (2011) Cell Cycle , vol.10 , pp. 2568-2573
    • Russo, I.1    Amornphimoltham, P.2    Weigert, R.3    Barlati, S.4    Bosetti, F.5
  • 60
    • 0033676255 scopus 로고    scopus 로고
    • Cyclooxygenase (COX) 1 and 2 in normal, inflamed, and ulcerated human gastric mucosa
    • Jackson LM1, Wu KC, Mahida YR, Jenkins D, Hawkey CJ. Cyclooxygenase (COX) 1 and 2 in normal, inflamed, and ulcerated human gastric mucosa. Gut 2000;47(6):762–770.
    • (2000) Gut , vol.47 , Issue.6 , pp. 762-770
    • Jackson, L.M.1    Wu, K.C.2    Mahida, Y.R.3    Jenkins, D.4    Hawkey, C.J.5
  • 61
    • 15044358766 scopus 로고    scopus 로고
    • Differential expression of COX-1 and COX-2 in the gastrointestinal tract of the rat
    • Haworth R, Oakley K, McCormack N, Pilling A. Differential expression of COX-1 and COX-2 in the gastrointestinal tract of the rat. Toxicol Pathol 2005;33(2):239–245.
    • (2005) Toxicol Pathol , vol.33 , Issue.2 , pp. 239-245
    • Haworth, R.1    Oakley, K.2    McCormack, N.3    Pilling, A.4
  • 64
    • 0036551298 scopus 로고    scopus 로고
    • Up-regulation of COX-2 by inhibition of COX-1 in the rat: A key to NSAID-induced gastric injury
    • Tanaka A, Araki H, Hase S, Komoike Y, Takeuchi K. Up-regulation of COX-2 by inhibition of COX-1 in the rat: A key to NSAID-induced gastric injury. Aliment Pharmacol Ther 2002;16(2):90–101.
    • (2002) Aliment Pharmacol Ther , vol.16 , Issue.2 , pp. 90-101
    • Tanaka, A.1    Araki, H.2    Hase, S.3    Komoike, Y.4    Takeuchi, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.