Cyclooxygenase (COX) 1 and 2 in normal, inflamed, and ulcerated human gastric mucosa

Gut

Volumn 47, Issue 6, 2000, Pages 762-770

  Jackson, L M ^a   Wu, K C ^a   Mahida, Y R ^a   Jenkins, D ^a   Hawkey, C J ^a  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

Cyclooxygenases; Gastric mucosa; Helicobacter pylori; Prostaglandins; Stomach; Ulceration

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; PROSTAGLANDIN E2;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LOCALIZATION; GASTRITIS; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MICROSCOPY; MYOFIBROBLAST; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; STOMACH BIOPSY; STOMACH MUCOSA; STOMACH ULCER; WESTERN BLOTTING;

BIOPSY; BLOTTING, WESTERN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROSTONE; EPITHELIAL CELLS; GASTRIC MUCOSA; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; MICROSCOPY, IMMUNOELECTRON; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; STOMACH ULCER;

EID: 0033676255     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.47.6.762     Document Type: Article

References (54)

1. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury
2. Prostaglandin production of human isolated gastric glands against indomethacin and ethanol injury. Evidence for direct cellular action of prostaglandin
3. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
4. The nature and time course of piroxicam-induced injury to human gastric mucosa
5. Towards a better aspirin
6. Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts
7. Regulation of mesangial cell cyclooxygenase synthesis by cytokines and glucocorticoids
8. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-α and phorbol ester
9. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes
10. Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer
11. Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages
12. Prostaglandin synthase 2
13. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice
14. Selective cyclooxygenase-2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach
15. Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats
16. Identification of parietal cells in gastric body mucosa with HMFG-2 monoclonal antibody
17. Migration of human intestinal laminal propria lymphocytes, macrophages and eosinophils following the loss of surface epithelial cells
18. Pharmacological analysis of cyclooxygenase-1 in inflammation
19. Mechanism of selective human prostaglandin G/H synthase-1 and -2 in intact cells
20. A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors
21. Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by idomethacin in the rat
22. Separation of aspirin's impairment of haemostasis from mucosal injury in the human stomach
23. Gastroduodenal mucosal defence
24. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues
25. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: A novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach
26. Expression of cyclooxygenase-1 and -2 by human gastric endothelial cells
27. Phenotypic and functional characterisation of myofibroblasts, macrophages, and lymphocytes migrating out of the human gastric lamina propria following the loss of epithelial cells
28. Prostaglandin E output by isolated rat gastric parietal cells and non-parietal epithelial cells
29. Prostaglandin production by intact isolated gastric parietal cells
30. 14C] arachidonic acid release by carbachol in the isolated canine parietal cells
31. The effects of acid secretagogues on protective agents of gastric cells from adult rabbit in vitro
32. Gastric mucosal endogenous prostanoids are involved in the cellular regulation of acid secretion from isolated parietal cells
33. Isolated cells from human gastric mucosa - Studies on physiological and pharmacological regulation
34. Effect of sofalcone on localization of 15-hydroxyprostaglandin dehydrogenase, an enzyme that metabolizes prostaglandin E2, in rat gastric mucosa: An immunohistochemical study
35. Inhibition of acid secretion in isolated canine parietal cells by prostaglandins
36. Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach
37. Effects of non-steroidal anti-inflammatory drugs on prostaglandin H synthase isoenzyme 2 (cyclooxygenase 2) production by porcine gastric mucosa in organ culture
38. Expression and localization of cyclooxygenase-2 in normal and ulcerated human gastric mucosa, and in cultured human endothelial cells
39. Expression of inducible nitric oxide synthase and cyclooxygenase-2 and modulation by omeprazole in Helicobacter pylori gastritis
40. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
41. Cyclooxygenase-2 is associated with macula densa of rat kidney and increases with salt restriction
42. Subcellular localization of prostaglandin endoperoxide synthase-2 in murine 3T3 cells
43. Localization of prostaglandin endoperoxide synthase-1 to the endoplasmic reticulum and nuclear envelope is independent of its C-terminal tetrapeptide-PTEL
44. Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2
45. Effect of Helicobacter pylori colonisation on gastric mucosal eicosanoid synthesis in patients taking non-steroidal anti-inflammatory drugs
46. Helicobacter pylori infection induces cyclooxygenase-2 expression in human gastric mucosa
47. Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity
48. Myofibroblasts in human granulation tissue
49. Plasticity of myofibroblasts appearing in granulation tissues after acetic acid treatment - Effect of bFGF
50. Roles of muscularis mucosae and myofibroblasts in the healing process of acetic acid-induced ulcer
51. E2 prostaglandins modulate cell proliferation in the small intestinal epithelium of the rat
52. Myofibroblast differentiation and the regulation of intestinal ion transport
53. Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2
54. No evidence of H. pylori-NSAID interaction in ulcer formation: Results of double-blind, placebo-controlled trials