Pharmacological profile of FK881(ASP6537), a novel potent and selective cyclooxygenase-1 inhibitor

Biochemical Pharmacology

Volumn 82, Issue 7, 2011, Pages 746-754

  Imanishi, Junko ^a   Morita, Yoshiaki ^a   Yoshimi, Eiji ^a   Kuroda, Kanae ^a   Masunaga, Tomoko ^a   Yamagami, Kaoru ^a   Kuno, Masako ^a   Hamachi, Emi ^a   Aoki, Satoshi ^a   Takahashi, Fumie ^a   Nakamura, Katsuya ^a   Miyata, Susumu ^a   Ohkubo, Yoshitaka ^a   Mutoh, Seitaro ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Cyclooxygenases 1; Gastrointestinal toxicity; Hyperalgesia; Inflammation; Inhibitor; NSAIDs

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; DICLOFENAC; FK 881; RECOMBINANT ENZYME; ROFECOXIB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; GASTROINTESTINAL TOXICITY; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; MALE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT;

ACETIC ACID; ANIMALS; ARTHRITIS, EXPERIMENTAL; CARRAGEENAN; CHO CELLS; CRICETINAE; CRICETULUS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; EDEMA; FEMALE; HUMANS; HYPERALGESIA; MALE; MICE; PAIN; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; STOMACH ULCER; TRIAZOLES;

EID: 80051800303     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.06.035     Document Type: Article

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