A complex of Htm1 and the oxidoreductase Pdi1 accelerates degradation of misfolded glycoproteins

Journal of Biological Chemistry

Volumn 291, Issue 23, 2016, Pages 12195-12207

  Pfeiffer, Anett ^a   Stephanowitz, Heike ^b   Krause, Eberhard ^b   Volkwein, Corinna ^a   Hirsch, Christian ^a,d   Jarosch, Ernst ^a   Sommer, Thomas ^a,c  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

^d BERLIN INSTITUTE OF HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CYTOLOGY; GLYCOPROTEINS; POLYSACCHARIDES;

COMPLEX PROCESSES; ENDOPLASMIC RETICULUM; N-ACETYLGLUCOSAMINE; N-GLYCAN STRUCTURES; NATIVE PROTEINS; NON-NATIVE SPECIES; PROTEIN DEGRADATION; SECRETORY GLYCOPROTEIN;

PROTEINS;

GLYCOPROTEIN; HOMOLOGOUS TO MANNOSIDASE 1; ISOMERASE; MANNOSIDASE; PROTEIN DISULFIDE ISOMERASE 1; UNCLASSIFIED DRUG; MNL1 PROTEIN, S CEREVISIAE; MULTIPROTEIN COMPLEX; PDI1 PROTEIN, S CEREVISIAE; POLYSACCHARIDE; PROTEIN BINDING; PROTEIN DISULFIDE ISOMERASE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENZYME ACTIVITY; ENZYME ASSAY; FUNGAL STRAIN; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN UNFOLDING; SACCHAROMYCES CEREVISIAE; STRUCTURE ANALYSIS; CHEMISTRY; ENDOPLASMIC RETICULUM; GENETICS; IMMUNOBLOTTING; METABOLISM; MUTATION;

ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; GLYCOPROTEINS; IMMUNOBLOTTING; MANNOSIDASES; MULTIPROTEIN COMPLEXES; MUTATION; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN DISULFIDE-ISOMERASES; PROTEIN FOLDING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84974603511     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.703256     Document Type: Article

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