Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

Journal of Controlled Release

Volumn 235, Issue , 2016, Pages 236-244

  Chen, Sam ^a   Tam, Yuen Yi C ^a   Lin, Paulo J C ^a,b   Sung, Molly M H ^a   Tam, Ying K ^a,b   Cullis, Pieter R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Acuitas Therapeutics   (Canada)

Author keywords

Drug delivery; Lipid exchange; Lipid nanoparticles; Liposomes; Nanomedicine; siRNA

Indexed keywords

DRUG DELIVERY; GENES; GENETIC ENGINEERING; LIPIDS; LIPOSOMES; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; PARTICLE SIZE;

DISSOCIATION RATES; INTRAVENOUS ADMINISTRATION; IONIZABLE AMINO LIPIDS; LIPID EXCHANGE; LIPID NANOPARTICLES; SIRNA; SMALL INTERFERING RNA (SIRNA); TISSUE PENETRATIONS;

DISSOCIATION;

APOENZYME; LIPID NANOPARTICLE; MACROGOL; NANOPARTICLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; BLOOD CLOTTING FACTOR 7; LIPID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; FEMALE; GENE SILENCING; HEART; IN VIVO STUDY; KIDNEY; LIVER; LIVER CELL; LUNG; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PANCREAS; PARTICLE SIZE; PRIORITY JOURNAL; RNA STABILITY; SPLEEN; ANIMAL; C57BL MOUSE; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; TISSUE DISTRIBUTION;

ADMINISTRATION, INTRAVENOUS; ANIMALS; FACTOR VII; FEMALE; GENE SILENCING; LIPIDS; LIVER; MICE; MICE, INBRED C57BL; NANOPARTICLES; PARTICLE SIZE; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 84973889249     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.05.059     Document Type: Article

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