Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration

Journal of Controlled Release

Volumn 196, Issue , 2014, Pages 106-112

  Chen, Sam ^a   Tam, Yuen Yi C ^a   Lin, Paulo J C ^a   Leung, Alex K K ^a   Tam, Ying K ^a,b   Cullis, Pieter R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Acuitas Therapeutics   (Canada)

Author keywords

Drug delivery; Lipid nanoparticles; Liposomes; Nanomedicine; siRNA; Subcutaneous administration

Indexed keywords

LIPOSOMES; MEDICAL NANOTECHNOLOGY;

GENE SILENCING; HEPATOCYTES; LIPID NANOPARTICLES; SIRNA;

DRUG DELIVERY;

BLOOD CLOTTING FACTOR 7; LIPID NANOPARTICLE; MACROGOL; NANOPARTICLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; LIPID;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; FEMALE; GENE SILENCING; LIPID COMPOSITION; LIVER CELL; MICROFLUIDICS; MOUSE; NONHUMAN; PARTICLE SIZE; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; MEDICINAL CHEMISTRY; SUBCUTANEOUS DRUG ADMINISTRATION; TISSUE DISTRIBUTION;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; FACTOR VII; FEMALE; GENE SILENCING; HEPATOCYTES; INFUSIONS, SUBCUTANEOUS; LIPIDS; MICE; MICE, INBRED C57BL; NANOPARTICLES; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 84908363683     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.09.025     Document Type: Article

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