One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

ACS Catalysis

Volumn 6, Issue 6, 2016, Pages 3753-3759

  France, Scott P ^a   Hussain, Shahed ^a   Hill, Andrew M ^a   Hepworth, Lorna J ^a   Howard, Roger M ^b   Mulholland, Keith R ^c   Flitsch, Sabine L ^a   Turner, Nicholas J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

Author keywords

biocatalysis; carboxylic acid reductase; imine reductase; piperidines; pyrrolidines; transaminase

Indexed keywords

BIOCATALYSTS; CARBOXYLIC ACIDS; CATALYSIS; ENZYMES; NITROGEN COMPOUNDS;

BIOCATALYSIS; HIGH CONVERSIONS; IMINE REDUCTASE; KETO ACIDS; METHYL GROUP; OMEGA-TRANSAMINASES; PIPERIDINES; PYRROLIDINES;

SYNTHESIS (CHEMICAL);

EID: 84973885473     PISSN: 21555435     EISSN: None     Source Type: Journal    
DOI: 10.1021/acscatal.6b00855     Document Type: Article

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