Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis

Oncotarget

Volumn 7, Issue 23, 2016, Pages 34453-34471

  Champa, Devora ^a   Orlacchio, Arturo ^a   Patel, Bindi ^a   Ranieri, Michela ^a   Shemetov, Anton A ^a   Verkhusha, Vladislav V ^a   Cuervo, Ana Maria ^a   Di Cristofano, Antonio ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Autophagy; Lysosomes; Necrosis; Obatoclax; Thyroid cancer

Indexed keywords

AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; DIPEPTIDE; MEFLOQUINE; METHYL ESTER LEUCYLLEUCYLMETHIONINE; OBATOCLAX; PEPTIDES AND PROTEINS; PLACEBO; PROTEIN BCL 2; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ATG5 PROTEIN, HUMAN; ATG7 PROTEIN, HUMAN; AUTOPHAGY RELATED PROTEIN 5; AUTOPHAGY RELATED PROTEIN 7; ENZYME INHIBITOR; PYRROLE DERIVATIVE; SMALL INTERFERING RNA;

ACIDIFICATION; ANAPLASTIC THYROID CANCER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL FUSION; CELL PERMEABILIZATION; CELL PROTECTION; CELL VACUOLE; CELLULAR DISTRIBUTION; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MOUSE; NONHUMAN; THYROID CANCER CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL PROLIFERATION; CHEMICALLY INDUCED; DRUG EFFECTS; KNOCKOUT MOUSE; METABOLISM; MULTICELLULAR SPHEROID; NECROSIS; RNA INTERFERENCE; THYROID CARCINOMA; THYROID TUMOR; TUMOR CELL CULTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY-RELATED PROTEIN 5; AUTOPHAGY-RELATED PROTEIN 7; CELL PROLIFERATION; ENZYME INHIBITORS; HUMANS; LYSOSOMES; MEFLOQUINE; MICE; MICE, KNOCKOUT; NECROSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SPHEROIDS, CELLULAR; THYROID CARCINOMA, ANAPLASTIC; THYROID NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 84973596652     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.9121     Document Type: Article

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