Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis

Journal of Allergy and Clinical Immunology

Volumn 137, Issue 3, 2016, Pages 758-766.e3

  Andiappan, Anand Kumar ^a,c   Sio, Yang Yie ^c   Lee, Bernett ^a   Suri, Bani Kaur ^c   Matta, Sri Anusha ^c   Lum, Josephine ^a   Foo, Shihui ^a   Koh, Geraldine ^a   Liu, Jianjun ^b   Zolezzi, Francesca ^a   Poidinger, Michael ^a   Wang, De Yun ^d   Rotzschke, Olaf ^a   Chew, Fook Tim ^c  

^a AGENCY FOR SCIENCE   (Singapore)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

Author keywords

17q21; allergic asthma; allergic rhinitis; eosinophil counts; IgE; ORMDL3; Singapore Chinese

Indexed keywords

IMMUNOGLOBULIN E; MEMBRANE PROTEIN; ORMDL3 PROTEIN, HUMAN;

ADULT; ALLELE; ALLERGIC ASTHMA; ALLERGIC RHINITIS; ARTICLE; ASTHMA ASSOCIATED OROSOMUCOID LIKE 3 GENE; CHROMATIN STRUCTURE; CHROMOSOME 17Q; CHROMOSOME 17Q12 21; COHORT ANALYSIS; CONTROLLED STUDY; EOSINOPHIL; EOSINOPHIL COUNT; ETHNICITY; FEMALE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; SINGAPORE; SINGLE NUCLEOTIDE POLYMORPHISM; YOUNG ADULT; ADOLESCENT; ASTHMA; BLOOD; CASE CONTROL STUDY; CHILD; CHROMOSOME 17; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; IMMUNOLOGY; LEUKOCYTE COUNT; META ANALYSIS (TOPIC); MIDDLE AGED; PHENOTYPE; QUANTITATIVE TRAIT LOCUS;

ADOLESCENT; ADULT; ALLELES; ASTHMA; CASE-CONTROL STUDIES; CHILD; CHROMOSOMES, HUMAN, PAIR 17; EOSINOPHILS; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN E; LEUKOCYTE COUNT; LINKAGE DISEQUILIBRIUM; MALE; MEMBRANE PROTEINS; META-ANALYSIS AS TOPIC; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; QUANTITATIVE TRAIT LOCI; RHINITIS, ALLERGIC; YOUNG ADULT;

EID: 84973563197     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.08.038     Document Type: Article

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