A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order

Journal of Allergy and Clinical Immunology

Volumn 128, Issue 5, 2011, Pages 996-1005

  Ramasamy, Adaikalavan ^a   Curjuric, Ivan ^b,c   Coin, Lachlan J ^a   Kumar, Ashish ^b,d,e   McArdle, Wendy L ^f   Imboden, Medea ^b,c   Leynaert, Benedicte ^g   Kogevinas, Manolis ^h,i,j,k   Schmid Grendelmeier, Peter ^l   Pekkanen, Juha ^m,n   Wjst, Matthias ^o   Bircher, Andreas J ^c,p   Sovio, Ulla ^a,q   Rochat, Thierry ^r   Hartikainen, Anna Liisa ^s   Balding, David J ^t   Jarvelin, Marjo Riitta ^a   Probst Hensch, Nicole ^b,c   Strachan, David P ^u   Jarvis, Deborah L ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF BRISTOL   (United Kingdom)

^g Epidemiologie   (France)

^h CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

ⁱ INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^j CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^k UNIVERSITY OF CRETE   (Greece)

^l UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^m NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

ⁿ UNIVERSITY OF EASTERN FINLAND   (Finland)

^o INSTITUTE OF EPIDEMIOLOGY   (Germany)

^p UNIVERSITY HOSPITAL BASEL   (Switzerland)

^q LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^r GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^s UNIVERSITY OF OULU   (Finland)

^t UNIVERSITY COLLEGE LONDON   (United Kingdom)

^u ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

more..

Author keywords

British 1958 Birth Cohort; European Community Respiratory Health Survey; gene environment interaction; genome wide association study; Hay fever; hygiene hypothesis; IgE sensitization to grass; Northern Finland Birth Cohort of 1966; older siblings; Swiss Study on Air Pollution and Lung Disease in Adults

Indexed keywords

CARRIER PROTEIN; CASPASE RECRUITMENT DOMAIN PROTEIN 4; EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15; HLA ANTIGEN; IMMUNOGLOBULIN E; LEUCIN RICH REPEAT CONTAINING 32; MEMBRANE PROTEIN; PROTEIN SERINE THREONINE KINASE; SOLUTE CARRIER FAMILY 25 MEMBER 46; THYMIC STROMAL LYMPHOPOIETIN; TOLL LIKE RECEPTOR 6; TRANSMEMBRANE PROTEIN 232; UNCLASSIFIED DRUG;

ADULT; ALLERGIC RHINITIS; ARTICLE; BIRTH ORDER; CHROMOSOME 11; COHORT ANALYSIS; CONTROLLED STUDY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GRASS; HUMAN; LOCUS CERULEUS; META ANALYSIS (TOPIC); PHENOTYPE; PRIORITY JOURNAL; SENSITIZATION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BIRTH ORDER; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; POACEAE; POLYMORPHISM, SINGLE NUCLEOTIDE; RHINITIS, ALLERGIC, SEASONAL;

EID: 80055099134     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.08.030     Document Type: Article

References (36)

1. M.L. Burr, B.K. Butland, S. King, and E. Vaughan-Williams Changes in asthma prevalence: two surveys 15 years apart Arch Dis Child 64 1989 1452 1456 (Pubitemid 19255182)
2. T.K. Ninan, and G. Russell Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart BMJ 304 1992 873 875
3. D. Vercelli Discovering susceptibility genes for asthma and allergy Nat Rev Immunol 8 2008 169 182 (Pubitemid 351323288)
4. J. Xu, D.S. Postma, T.D. Howard, G.H. Koppelman, S.L. Zheng, and O.C. Stine Major genes regulating total serum immunoglobulin E levels in families with asthma Am J Hum Genet 67 2000 1163 1173
5. C. Ober, and S. Hoffjan Asthma genetics 2006: the long and winding road to gene discovery Genes Immun 7 2006 95 100 (Pubitemid 43336051)
6. G. Duetsch, T. Illig, S. Loesgen, K. Rohde, N. Klopp, and N. Herbon STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study Hum Mol Genet 11 2002 613 621 (Pubitemid 34285132)
7. S. Weidinger, C. Gieger, E. Rodriguez, H. Baurecht, M. Mempel, and N. Klopp Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus PLoS Genet 4 2008 e1000166
8. M.F. Moffatt, I.G. Gut, F. Demenais, D.P. Strachan, E. Bouzigon, and S. Heath A large-scale, consortium-based genomewide association study of asthma N Engl J Med 363 2010 1211 1221
9. Y.I. Wan, D.P. Strachan, D.M. Evans, J. Henderson, T. McKeever, and J.W. Holloway A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom J Allergy Clin Immunol 127 2011 223 231 e1-3
10. D. Strachan Hay fever, hygiene, and household size BMJ 299 1989 1259 1260 (Pubitemid 19280051)
11. D.P. Strachan Family size, infection and atopy: the first decade of the "hygiene hypothesis." Thorax 55 suppl 1 2000 S2 S10 (Pubitemid 30468238)
12. W. Karmaus, and C. Botezan Does a higher number of siblings protect against the development of allergy and asthma? A review J Epidemiol Community Health 56 2002 209 217 (Pubitemid 34174446)
13. D.P. Strachan, A.R. Rudnicka, C. Power, P. Shepherd, E. Fuller, and A. Davis Lifecourse influences on health among British adults: effects of region of residence in childhood and adulthood Int J Epidemiol 36 2007 522 531 (Pubitemid 47244549)
14. P.G. Burney, C. Luczynska, S. Chinn, and D. Jarvis The European Community Respiratory Health Survey Eur Respir J 7 1994 954 960 (Pubitemid 24153598)
15. D. Jarvis, S. Chinn, C. Luczynska, and P. Burney The association of family size with atopy and atopic disease Clin Exp Allergy 27 1997 240 245 (Pubitemid 27122116)
16. Genes for asthma? An analysis of the European Community Respiratory Health Survey Am J Respir Crit Care Med 156 1997 1773 1780
17. P. Rantakallio Groups at risk in low birth weight infants and perinatal mortality Acta Paediatr Scand 193 suppl 193 1969 1
18. S.H. Downs, C. Schindler, L.J. Liu, D. Keidel, L. Bayer-Oglesby, and M.H. Brutsche Reduced exposure to PM10 and attenuated age-related decline in lung function N Engl J Med 357 2007 2338 2347 (Pubitemid 350223388)
19. U. Ackermann-Liebrich, B. Kuna-Dibbert, N.M. Probst-Hensch, C. Schindler, D. Felber Dietrich, and E.Z. Stutz Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003: methods and characterization of participants Soz Praventivmed 50 2005 245 263 (Pubitemid 41386704)
20. R Development Core Team (2008). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0. Available at: http://www.R-project.org. Accessed September 29, 2011.
21. HuGE Literature Finder. HuGE navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePubLit.do. Accessed September 9, 2010.
22. S. Haider, B. Ballester, D. Smedley, J. Zhang, P. Rice, and A. Kasprzyk BioMart Central Portal - unified access to biological data Nucleic Acids Res 37 Web Server issue 2009 W23 W27
23. C.E. Murcray, J.P. Lewinger, and W.J. Gauderman Gene-environment interaction in genome-wide association studies Am J Epidemiol 169 2009 219 226
24. M.J. Ege, D. Strachan, W. Cookson, M. Moffatt, I. Gut, and M. Lathrop Gene-environment interaction for childhood asthma and exposure to farming in Central Europe J Allergy Clin Immunol 127 2011 138 144
25. J. Esparza-Gordillo, S. Weidinger, R. Fölster-Holst, A. Bauerfeind, F. Ruschendorf, and G. Patone A common variant on chromosome 11q13 is associated with atopic dermatitis Nat Genet 41 2009 596 601
26. G. O'Regan, L. Campbell, H. Cordell, A. Irvine, W. McLean, and S. Brown Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations J Allergy Clin Immunol 125 2010 170 174 e1-2
27. I. Marenholz, A. Bauerfeind, J. Esparza-Gordillo, T. Kerscher, R. Granell, and R. Nickel The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever Hum Mol Genet 20 2011 2443 2449
28. C. Fang, L.Q. Siew, C.J. Corrigan, and S. Ying The role of thymic stromal lymphopoietin in allergic inflammation and chronic obstructive pulmonary disease Arch Immunol Ther Exp (Warsz) 58 2010 81 90
29. G. Weinmayr, J. Genuneit, G. Nagel, B. Björkstén, M. van Hage, and A. Priftanji International variations in associations of allergic markers and diseases in children: ISAAC Phase Two Allergy 65 2010 766 775
30. B.B. Levine, R.H. Stember, and M. Fotino Ragweed hay fever: genetic control and linkage to HL-A haplotypes Science 178 1972 1201 1203
31. A. Dixon, L. Liang, M. Moffatt, W. Chen, S. Heath, and K. Wong A genome-wide association study of global gene expression Nat Genet 39 2007 1202 1207 (Pubitemid 47482680)
32. Genome-wide evaluation of validity and efficiency of genotype imputation [database on the Internet]. Available at: http://www.sph.umich.edu/csg/liang/ imputation/. Accessed September 9, 2010.
33. A. Koivikko, R. Kupias, Y. Mäkinen, and A. Pohjola Pollen seasons: forecasts of the most important allergenic plants in Finland Allergy 41 1986 233 242 (Pubitemid 16039027)
34. G.M. Hunninghake, M.E. Soto-Quiros, L. Avila, H.P. Kim, J. Lasky-Su, and N. Rafaels TSLP polymorphisms are associated with asthma in a sex-specific fashion Allergy 65 2010 1566 1575
35. S. Michel, L. Liang, M. Depner, N. Klopp, A. Ruether, and A. Kumar Unifying candidate gene and GWAS approaches in asthma PLoS One 5 2010 e13894
36. C. Cramer, E. Link, M. Horster, S. Koletzko, C.P. Bauer, and D. Berdel Elder siblings enhance the effect of filaggrin mutations on childhood eczema: results from the 2 birth cohort studies LISAplus and GINIplus J Allergy Clin Immunol 125 2010 1254 1260 e5