Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore

Cytokine

Volumn 56, Issue 2, 2011, Pages 218-223

  Andiappan, Anand Kumar ^a   Parate, Pallavi Nilkanth ^a   Anantharaman, Ramani ^a   Suri, Bani Kaur ^a   Wang, De Yun ^a   Chew, Fook Tim ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

AR; Asthma; BDNF; Genetic predisposition; Neurotrophin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; ALLERGIC ASTHMA; ALLERGIC RHINITIS; ARTICLE; BDNF GENE; CHINESE; CONTROLLED STUDY; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUESTIONNAIRE; SELF REPORT; SINGAPORE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ASTHMA; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHINA; FEMALE; GENETIC VARIATION; HUMANS; HYPERSENSITIVITY; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RHINITIS; SINGAPORE;

EID: 80053326632     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.05.008     Document Type: Article

References (59)

1. Nathan R.A. The burden of allergic rhinitis. Allergy and Asthma Proceedings 2007, 28:3-9.
2. Bousquet J., Khaltaev N., Cruz A.A., Denburg J., Fokkens W.J., Togias A., et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008, 63:8-160.
3. Devereux G. The increase in the prevalence of asthma and allergy: food for thought. Nature Reviews Immunology 2006, 6:869-874.
4. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nature Reviews Immunology 2008, 8:169-182.
5. Postma D.S., Koppelman G.H., Meyers D.A. The genetics of atopy and airway hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2000, 162:S118-S123.
6. MacLean J.A., Eidelman F.J. The genetics of atopy and atopic eczema. Archives of Dermatology 2001, 137:1474-1476.
7. Kabesch M. Next generation genetics in allergy. Current Opinion in Allergy and Clinical Immunology 2010, 10:407.
8. Ng T.P., Tan W.C. Epidemiology of allergic rhinitis and its associated risk-factors in singapore. International Journal of Epidemiology 1994, 23:553-558.
9. Wuthrich B., Cozzio A., Roll A., Senti G., Kundig T., Schmid-Grendelmeier P. Atopic eczema: Genetics or environment?. Annals of Agricultural and Environmental Medicine 2007, 14:195-201.
10. Choi S.H., Yoo Y., Yu J., Rhee C.S., Min Y.G., Koh Y.Y. Bronchial hyperresponsiveness in young children with allergic rhinitis and its risk factors. Allergy 2007, 62:1051-1056.
11. Nockher W.A., Renz H. Neurotrophins in allergic diseases: from neuronal growth factors to intercellular signaling molecules. Journal of Allergy and Clinical Immunology 2006, 117:583-589.
12. Raap U., Kapp A. Neuroimmunological findings in allergic skin diseases. Current Opinion in Allergy and Clinical Immunology 2005, 5:419-424.
13. Nassenstein C., Kerzel S., Braun A. Neurotrophins and neurotrophin receptors in allergic asthma. Ngf and related molecules in health and disease 2004, 347-367. Elsevier Science Bv, Amsterdam. L. Aloe, L. Calza (Eds.).
14. Howarth P.H. ABC of allergies - pathogenic mechanisms: a rational basis for treatment. British Medical Journal 1998, 316:758-761.
15. Raap U., Braunstahl G.J. The role of neurotrophins in the pathophysiology of allergic rhinitis. Current Opinion in Allergy and Clinical Immunology 2010, 10:8-13.
16. Bibel M., Barde Y.A. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes & Development 2000, 14:2919-2937.
17. Lewin G.R., Barde Y.A. Physiology of the neurotrophins. Annual Review of Neuroscience 1996, 19:289-317.
18. Lessmann V., Gottmann K., Malcangio M. Neurotrophin secretion: current facts and future prospects. Progress in Neurobiology 2004, 72:165-166.
19. Braun A., Lommatzsch M., Mannsfeldt A., Neuhaus-Steinmetz U., Fischer A., Schnoy N., et al. Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation. American Journal of Respiratory Cell and Molecular Biology 1999, 21:537-546.
20. Nockher W.A. The role of neurotrophins in the pathogenesis of asthma and related diseases: allergy and asthma as prototypic neuro-immune diseases?. Clinical and Experimental Allergy 2002, 32:1266-1268.
21. Coffey C.S., Mulligan R.M., Schlosser R.J. Mucosal expression of nerve growth factor and brain-derived neurotrophic factor in chronic rhinosinusitis. American Journal of Rhinology & Allergy 2009, 23:571-574.
22. Hahn C., Islamian A.P., Renz H., Nockher W.A. Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation. Journal of Allergy and Clinical Immunology 2006, 117:787-794.
23. Raap U., Werfel T., Goltz C., Deneka N., Langer K., Bruder M., et al. Circulating levels of brain-derived neurotrophic factor correlate with disease severity in the intrinsic type of atopic dermatitis. Allergy 2006, 61:1416-1418.
24. Martinowich K., Manji H., Lu B. New insights into BDNF function in depression and anxiety. Nature Neuroscience 2007, 10:1089-1093.
25. Grande I., Fries G.R., Kunz M., Kapczinski F. The Role of BDNF as a mediator of neuroplasticity in bipolar disorder. Psychiatry Investigation 2010, 7:243-250.
26. Post R.M. Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications. Journal of Psychiatric Research 2007, 41:979-990.
27. Kuipers S.D., Bramham C.R. Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy. Current Opinion in Drug Discovery & Development 2006, 9:580-586.
28. Miller F.D., Kaplan D.R. TRK makes the retrograde. Science 2002, 295:1471-1473.
29. Noga O., Englmann C., Hanf G., Grutzkau A., Guhl S., Kunkel G. Activation of the specific neurotrophin receptors TrkA, TrkB and TrkC influences the function of eosinophils. Clinical and Experimental Allergy 2002, 32:1348-1354.
30. Virchow J.C., Julius P., Lommatzsch M., Luttmann W., Renz H., Braun A. Neurotophins are increased in bronchoalveolar lavage fluid after segmental allergen provocation. American Journal of Respiratory and Critical Care Medicine 1998, 158:2002-2005.
31. Nassenstein C., Braun A., Erpenbeck V.J., Lommatzsch M., Schmidt S., Krug N., et al. The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma. Journal of Experimental Medicine 2003, 198:455-467.
32. Lommatzsch M., Braun A., Renz H. Neurotrophins in allergic airway dysfunction what the mouse model is teaching us. Neuroendocrine and neural regulation of autoimmune and inflammatory disease: molecular systems, and clinical insights 2003, 241-249. New York Acad Sciences, New York. E.M. Sternberg, F.G. Haour, C.C. Smith (Eds.).
33. Rothenberg M.E. Mechanisms of disease - Eosinophilia. New England Journal of Medicine 1998, 338:1592-1600.
34. Demonchy J.G.R., Kauffman H.F., Venge P., Koeter G.H., Jansen H.M., Sluiter H.J., et al. Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. American Review of Respiratory Disease 1985, 131:373-376.
35. Maisonpierre P.C., Lebeau M.M., Espinosa R., Ip N.Y., Belluscio L., Delamonte S.M., et al. Human and rat brain-derived neurotrophic factor and neurotrophin-3 - gene structures, distributions, and chromosomal localizations. Genomics 1991, 10:558-568.
36. Hoffjan S., Parwez Q., Petrasch-Parwez E., Stemmler S. Variation in the BDNF and NGFB genes in German atopic dermatitis patients. Molecular and Cellular Probes 2009, 23:35-38.
37. Zeilinger S., Pinto L.A., Nockher W.A., Depner M., Klopp N., Illig T., et al. The effect of BDNF gene variants on asthma in German children. Allergy 2009, 64:1790-1794.
38. Szczepankiewicz A., Breborowicz A., Skibinska M., Wilkosc M., Tomaszewska M., Hauser J. Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic children. Pediatric Allergy and Immunology 2007, 18:293-297.
39. Szczepankiewicz A., Rose-Zerilli M.J., Barton S.J., Holgate S.T., Holloway J.W. Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families. International Archives of Allergy and Immunology 2009, 149:343-349.
40. Szczepankiewicz A., Breborowicz A., Sobkowiak P., Popiel A. Association of BDNF Gene Polymorphism with Asthma in Polish children. World Allergy Organization Journal 2010, 3:235-238. 10.1097/WOX.0b013e3181eedb6.
41. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112:257-269.
42. Andiappan A.K., Anantharaman R., Parate P., Wang D.Y., Chew F.T. Evaluating the transferability of Hapmap SNPs to a Singapore Chinese population. Bmc Genetics 2010, 11:36.
43. Shek L.P.C., Tay A.H.N., Chew F.T., Goh D.L.M., Lee B.W. Genetic susceptibility to asthma and atopy among Chinese in Singapore - linkage to markers on chromosome 5q31-33. Allergy 2001, 56:749-753.
44. Bousquet J., van Cauwenberge P., Khaltaev N., Ait-Khaled N., Annesi-Maesano I., Baena-Cagnani C., et al. Allergic rhinitis and its impact on asthma. Journal of Allergy and Clinical Immunology 2001, 108:S147-S334.
45. Gibbs R.A., Belmont J.W., Hardenbol P., Willis T.D., Yu F.L., Yang H.M., et al. The International HapMap Project. Nature 2003, 426:789-796.
46. de Bakker P.I.W., Yelensky R., Pe'er I., Gabriel S.B., Daly M.J., Altshuler D. Efficiency and power in genetic association studies. Nature Genetics 2005, 37:1217-1223.
47. Gabriel S.B., Schaffner S.F., Nguyen H., Moore J.M., Roy J., Blumenstiel B., et al. The structure of haplotype blocks in the human genome. Science 2002, 296:2225-2229.
48. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
49. Petryshen T.L., Sabeti P.C., Aldinger K.A., Fry B., Fan J.B., Schaffner S.F., et al. Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Molecular Psychiatry 2010, 15:810-815.
50. Chuu J.Y.J., Taylor J.L., Tinklenberg J., Noda A., Yesavage J., Murphy G.M. The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease. Journal of Alzheimer's Disease 2006, 9:43-49.
51. Henningsson S., Borg J., Lundberg J., Bah J., Lindström M., Ryding E., et al. Genetic variation in brain-derived neurotrophic factor is associated with serotonin transporter but not serotonin-1A receptor availability in men. Biological Psychiatry 2009, 66:477-485.
52. Chen Z.Y., Jing D.Q., Bath K.G., Ieraci A., Khan T., Siao C.J., et al. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 2006, 314:140-143.
53. Scuri M., Samsell L., Piedimonte G. The role of neurotrophins in inflammation and allergy. Inflammation Allergy - Drug Targets (Formerly ???Current Drug Targets) 2010, 9:173-180.
54. Raap U., Fokkens W., Bruder M., Hoogsteden H., Kapp A., Braunstahl G.J. Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis. Allergy 2008, 63:468-475.
55. Massa S.M., Yang T., Xie Y.M., Shi J., Bilgen M., Joyce J.N., et al. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. Journal of Clinical Investigation 2010, 120:1774-1785.
56. Kingwell K. Neurodegenerative disease BDNF copycats. Nature Reviews Drug Discovery 2010, 9:433.
57. Xu M.Q., Li S., Xing Q.H., Gao R., Feng G.Y., Lin Z.G., et al. Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study. European Journal of Human Genetics 2010, 18:707-712.
58. Hon K.L.E., Leung T.F. Seromarkers in childhood atopic dermatitis. Expert Review of Dermatology 2010, 5:299-314.
59. Lommatzsch M., Schloetcke K., Klotz J., Schuhbaeck K., Zingler D., Zingler C., et al. Brain-derived neurotrophic factor in platelets and airflow limitation in asthma. American Journal of Respiratory and Critical Care Medicine 2005, 171:115-120.