Magnetic resonance imaging reveals altered distribution of hepatic fat in children with type 1 diabetes compared to controls

Metabolism: Clinical and Experimental

Volumn 64, Issue 8, 2015, Pages 872-878

  Regnell, Simon E ^a   Peterson, Pernilla ^a   Trinh, Lena ^a   Broberg, Per ^a   Leander, Peter ^a   Lernmark, Åke ^a   Månsson, Sven ^a   Larsson, Helena Elding ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Diabetes complications; Fat fraction; Magnetic resonance imaging; Non alcoholic fatty liver disease; Type 1 diabetes

Indexed keywords

CHOLESTEROL; HEMOGLOBIN A1C; INSULIN; TRIACYLGLYCEROL;

ADOLESCENT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY COMPOSITION; CHILD; CHILDHOOD DISEASE; COMPARATIVE STUDY; CONTINUOUS INFUSION; CONTROLLED STUDY; DIABETIC PATIENT; FEMALE; HEPATIC FAT FRACTION; HUMAN; INCIDENTAL FINDING; INJECTION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN INFUSION; LIVER WEIGHT; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; ADIPOSE TISSUE; COMPLICATION; DIABETES MELLITUS, TYPE 1; LIVER; METABOLISM; NON-ALCOHOLIC FATTY LIVER DISEASE; PROCEDURES;

ADIPOSE TISSUE; ADOLESCENT; CHILD; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; INSULIN; LIVER; MAGNETIC RESONANCE IMAGING; MALE; NON-ALCOHOLIC FATTY LIVER DISEASE;

EID: 84942980370     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2015.04.002     Document Type: Article

References (29)

1. Adams LA, Angulo P, Lindor KD. Nonalcoholic fatty liver disease. CMAJ 2005;172(7):899-905.
2. Hamaguchi M, Kojima T, Takeda N, Nakagawa T, Taniguchi H, Fujii K, et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 2005;143(10): 722-8.
3. Regnell SE, Lernmark Å. Hepatic steatosis in type 1 diabetes. Rev Diabet Stud 2011;8(4):454-67.
4. Schwimmer JB, Behling C, Newbury R, Deutsch R, Nievergelt C, Schork NJ, et al. Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology 2005;42(3):641-9.
5. Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, Angulo P. The natural history of nonalcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 2009;58(11):1538-44.
6. Al-Hussaini AA, Sulaiman N, Al-Zahrani M, Alenazi A, Khan M. Prevalence of liver disease among type 1 diabetic children. J Pediatr Gastroenterol Nutr 2010;42(3):641-9.
7. Tominaga K, Kurata JH, Chen YK, Fujimoto E, Miyagawa S, Abe I, et al. Prevalence of fatty liver in Japanese children and relationship to obesity. An epidemiological ultrasonographic survey. Dig Dis Sci 1995;40(9):2002-9.
8. Targher G, Bertolini L, Padovani R, Rodella S, Zoppini G, Pichiri I, et al. Prevalence of non-alcoholic fatty liver disease and its associationwith cardiovascular disease in patients with type 1 diabetes. J Hepatol 2010;53(4):713-8.
9. Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 2002; 123(3):745-50.
10. Torbenson M, Chen YY, Brunt E, Cummings OW, Gottfried M, Jakate S, et al. Glycogenic hepatopathy: an underrecognized hepatic complication of diabetes mellitus. Am J Surg Pathol 2006;30(4):508-13.
11. Saikusa M, Yatsuga S, Tonan T, Koga Y. Glycogenic hepatopathy and non-alcoholic fatty liver disease in type 1 diabetes patients. Pediatr Int 2013;55(6):806-7.
12. Borra RJ, Salo S, Dean K, Lautamäki R, Nuutila P, Komu M, et al. Nonalcoholic fatty liver disease: rapid evaluation of liver fat content with in-phase and out-of-phase MR imaging. Radiology 2009;250(1):130-6.
13. Mansson S, Peterson P, Johansson E. Quantification of lowfat contents: a comparison of MR imaging and spectroscopy methods at 1.5 and 3 T. Magn Reson Imaging 2012;30(10):1461-7.
14. Hines CD, Agni R, Roen C, Rowland I, Hernando D, Bultman E, et al. Validation of MRI biomarkers of hepatic steatosis in the presence of iron overload in the ob/ob mouse. J Magn Reson Imaging 2012;35(4):844-51.
15. Schwenzer NF, Springer F, Schraml C, Stefan N, Machann J, Schick F. Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance. J Hepatol 2009;51(3):433-45.
16. Capitan V, Petit JM, Aho S, Lefevre PH, Favelier S, Loffroy R, et al. Macroscopic heterogeneity of liver fat: an MR-based study in type-2 diabetic patients. Eur Radiol 2012;22(10):2161-8.
17. Ferrannini E, Wahren J, Faber OK, Felig P, Binder C, DeFronzo RA. Splanchnic and renal metabolism of insulin in human subjects: a dose-response study. Am J Physiol 1983;244(6): E517-27.
18. Targher G, Bertolini L, Chonchol M, Rodella S, ZoppiniG, Lippi G, et al. Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and retinopathy in type 1 diabetic patients. Diabetologia 2010;53:1341-8.
19. Targher G, Pichiri I, Zoppini G, Trombetta M, Bonora E. Increased prevalence of chronic kidney disease in patients with type 1 diabetes and non-alcoholic fatty liver. Diabet Med 2012;29(6):220-6.
20. Larsson K, Elding-Larsson H, Cederwall E, Kockum K, Niederud J, Sjöblad S, et al. Genetic and perinatal factors as risk for childhood type 1 diabetes. Diabetes Metab Res Rev 2004;20(6):429-37.
21. Karlberg J, Luo ZC, Albertsson-Wikland K. Body mass index reference values (mean and SD) for Swedish children. Acta Paediatr 2001;90(12):1427-34.
22. YuH, Shimakawa A, Hines CD, McKenzie CA, Hamilton G, Sirlin CB, et al. Combination of complex-based andmagnitude-based multiecho water-fat separation for accurate quantification of fat-fraction. Magn Reson Med 2011;66(1):199-206.
23. Burt AD, Mutton A, Day CP. Diagnosis and interpretation of steatosis and steatohepatitis. Semin Diagn Pathol 1998;15(4): 246-58.
24. Perseghin G, Lattuada G, De Cobelli F, Esposito A, Constantino F, Canu T, et al. Reduced intrahepatic fat content is associated with increased whole-body lipid oxidation in patients with type 1 diabetes. Diabetologia 2005;48(12):2615-21.
25. Polonsky KS, Given BD, Hirsch L, Shapiro ET, Tillil H, Beebe C, et al. Quantitative study of insulin secretion and clearance in normal and obese subjects. J Clin Invest 1988;81(2):435-41.
26. Waldhausl W, Bratusch-Marrain P, Gasic S, Korn A, Nowotny P. Insulin production rate following glucose ingestion estimated by splanchnic C-peptide output in normal man. Diabetologia 1979;17(4):221-7.
27. Llauradó G, Sevastianova K, Sädevirta S, Hakkaraine A, Lundbom N, Orcho-Melander M, et al. Liver fat content and hepatic insulin sensitivity in overweight patients with type 1 diabetes. J Clin Endocrinol Metab 2015;100(2):607-16.
28. El-Karaksy HM, Anwar G, Esmat G. Prevalence of hepatic abnormalities in a cohort of Egyptian children with type 1 diabetes mellitus. Pediatr Diabetes 2010;11(7):462-70.
29. Bonekamp S, Tang A, Mashhood A, Wolfson T, Changchien C, Middleton MS, et al. Spatial distribution of MRI-determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease. J Magn Reson Imaging 2014;39(6): 1525-32.