Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis

Clinical Science

Volumn 130, Issue 8, 2016, Pages 575-586

  Evans, Iona C ^a   Barnes, Josephine L ^a   Garner, Ian M ^a   Pearce, David R ^a   Maher, Toby M ^a,b   Shiwen, Xu ^a   Renzoni, Elisabetta A ^b   Wells, Athol U ^b   Denton, Christopher P ^a   Laurent, Geoffrey J ^c   Abraham, David J ^a   McAnulty, Robin J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Cyclooxygenase 2; DNA methylation; Fibroblast; Idiopathic pulmonary fibrosis; Prostaglandin E2; Systemic sclerosis

Indexed keywords

COLLAGEN; CYCLOOXYGENASE 2; DECITABINE; MESSENGER RNA; PROSTAGLANDIN E2; REGULATOR PROTEIN; SMALL INTERFERING RNA; THYROID CANCER PROTEIN 1; UNCLASSIFIED DRUG; C8ORF4 PROTEIN, HUMAN; DNA METHYLTRANSFERASE; ENZYME INHIBITOR; PTGS2 PROTEIN, HUMAN; TUMOR PROTEIN;

ADULT; APOPTOSIS; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME 8; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; ENZYME REGULATION; EPIGENETICS; FEMALE; GENE EXPRESSION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG FIBROBLAST; LUNG FIBROSIS; LUNG PARENCHYMA; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; MOLECULAR PATHOLOGY; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; PROSTAGLANDIN SYNTHESIS; TRANSCRIPTION REGULATION; UPREGULATION; AGED; ANTAGONISTS AND INHIBITORS; BINDING SITE; CASE CONTROL STUDY; CELL CULTURE; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; GENOTYPE; LUNG; METABOLISM; PATHOLOGY; PHENOTYPE; RNA INTERFERENCE; SYSTEMIC SCLEROSIS;

AGED; BINDING SITES; CASE-CONTROL STUDIES; CELL PROLIFERATION; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; DNA METHYLATION; DNA MODIFICATION METHYLASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; EPIGENESIS, GENETIC; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOTYPE; HUMANS; LUNG; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PHENOTYPE; PROMOTER REGIONS, GENETIC; PULMONARY FIBROSIS; RNA INTERFERENCE; RNA, MESSENGER; SCLERODERMA, SYSTEMIC; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84973519350     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20150697     Document Type: Article

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