Impaired synthesis of prostaglandin E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF-/- mice: Implications for fibroproliferation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 284, Issue 6 28-6, 2003, Pages

  Charbeneau, Ryan P ^a   Christensen, Paul J ^a   Chrisman, Cara J ^a   Paine III, Robert ^a,b   Toews, Galen B ^a,b   Peters Golden, Marc ^a   Moore, Bethany B ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^c 6301 MSRB III ^*  (United States)

Author keywords

Cyclooxygenase 1; Cyclooxygenase 2; Granulocyte macrophage colony stimulating factor; Idiopathic pulmonary fibrosis

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FLUORESCEIN ISOTHIOCYANATE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; SURFACTANT PROTEIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME IMMUNOASSAY; FIBROGENESIS; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROBLAST; LUNG FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; TISSUE HOMOGENATE;

EID: 0037834817     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00350.2002     Document Type: Article

References (38)

1. American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment International consensus statement American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med 161: 646-664, 2000.
2. Baum B, Moss S, Breul R, and Crystal R. Effect of cyclic AMP on the intracellular degradation of newly synthesized collagen. J Biol Chem 255: 2843-2847, 1980.
3. Bitterman PB, Wewers MD, Rennard SI, Adelberg S, and Crystal R. Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators. J Clin Invest 77: 700-708, 1986.
4. Borok Z, Gillissen A, Buhl R, Hoyt R, Hubbard R, Osaki T, Rennard S, and Crystal R. Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E. Am Rev Respir Dis 144: 1080-1084, 1991.
5. Brock TG, McNish RW, Coffey MJ, Ojo TC, Phare SM, and Peters-Golden M. Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes. J Immunol 156: 2522-2527, 1996.
6. Canturk NZ, Vural B, Esen N, Canturk Z, Oktay G, Kirkali G, and Solakoglu S. Effects of granulocyte-macrophage colony-stimulating factor on incisional wound healing in an experimental diabetic rat model. Endocr Res 25: 105-116, 1999.
7. Christensen PJ, Bailie MB, Goodman RE, O'Brien AD, Toews GB, and Paine R III. Role of diminished epithelial GM-CSF in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 279: L487-L495, 2000.
8. Christensen PJ, Goodman RE, Pastoriza L, Moore B, and Toews GB. Induction of lung fibrosis in the mouse by intratracheal instillation of fluorescein isothiocyanate is not T-cell-dependent. Am J Pathol 155: 1773-1779, 1999.
9. Corti M, Brody AR, and Harrison JH. Isolation and primary culture of murine alveolar type II cells. Am J Respir Cell Mol Biol 14: 309-315, 1996.
10. Dranoff G, Crawford AD, Sadelain M, Ream B, Rashid A, Bronson RT, Dickersin GR, Bachurski CJ, Mark EL, Whitsett JA, and Mulligan RC. Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science 264: 713-716, 1994.
11. Elias JA, Rossman MD, Zurier RB, and Daniele RP. Human alveolar macrophage inhibition of lung fibroblast growth. A prostaglandin-dependent process. Am Rev Respir Dis 131: 94-99, 1985.
12. Fernberg JO, Brosjo O, Friesland S, and Masucci G. GM-CSF at relatively high topic concentrations can significantly enhance the healing of surgically induced chronic wounds after radiotherapy. Med Oncol 18: 231-235, 2001.
13. Goldstein R and Polgar P. The effect and interaction of bradykinin and prostaglandins on protein and collagen production by lung fibroblasts. J Biol Chem 257: 8630-8633, 1982.
14. Groves RW and Schmidt-Lucke JA. Recombinant human GM-CSF in the treatment of poorly healing wounds. Adv Skin Wound Care 13: 107-112, 2000.
15. Huffman J, Hull W, Dranoff G, Mulligan R, and Whitsett J. Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice. J Clin Invest 97: 649-655, 1996.
16. Huffman Reed JA, Rice WR, Zsengeller ZK, Wert SE, Dranoff G, and Whitsett JA. GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice. Am J Physiol Lung Cell Mol Physiol 273: L715-L725, 1997.
17. Ikegami R, Sugimoto Y, Segi E, Katsuyama M, Karahashi H, Amano F, Maruyama T, Yamane H, Tsuchiya S, and Ichikawa A. The expression of prostaglandin E receptors EP2 and EP4 and their different regulation by lipopolysaccharide in C3H/HeN peritoneal macrophages. J Immunol 166: 4689-4696, 2001.
18. Keerthisingam CB, Jenkins RG, Harrison NK, Hernandez-Rodriguez NA, Booth H, Laurent GJ, Hart SL, Foster ML, and McAnulty RJ. Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factorbeta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. Am J Pathol 158: 1411-1422, 2001.
19. Korn J, Halushka P, and Leroy E. Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production. J Clin Invest 65: 543-554, 1980.
20. 2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase2-dependent. Am J Respir Cell Mol Biol 27: 752-759, 2002.
21. Leslie CC, McCormick-Shannon K, Mason RJ, and Shannon JM. Proliferation of rat alveolar epithelial cells in low density primary culture. Am J Respir Cell Mol Biol 9: 64-72, 1993.
22. Marques da Costa R, Jesus FM, Aniceto C, and Mendes M. Double-blind randomized placebo-controlled trial of the use of granulocyte-macrophage colony-stimulating factor in chronic leg ulcers. Am J Surg 173: 165-168, 1997.
23. Moore BB, Coffey MJ, Christensen P, Sitterding S, Ngan R, Wilke CA, McDonald R, Phare SM, Peters-Golden M, Paine R III, and Toews GB. GM-CSF regulates bleomycin induced pulmonary fibrosis via a prostaglandin-dependent mechanism. J Immunol 165: 4032-4039, 2000.
24. Moore BB, Paine R III, Christensen PJ, Moore TA, Sitterding S, Ngan R, Wilke CA, Kuziel WA, and Toews GB. Protection from pulmonary fibrosis in the absence of CCR2 signaling. J Immunol 167: 4368-4377, 2001.
25. 2 synthesis by lung fibroblasts isolated from rats with bleomycin-induced lung fibrosis. Int J Exp Pathol 80: 41-49, 1999.
26. 2 on fibronectin release from human alveolar macrophages. Am Rev Respir Dis 141: 965-969, 1990.
27. Pan T, Mason RJ, Westcott JY, and Shannon JM. Rat alveolar type II cells inhibit lung fibroblast proliferation in vitro. Am J Respir Cell Mol Biol 25: 353-361, 2001.
28. Payne WG, Ochs DE, Meltzer DD, Hill DP, Mannari RJ, Robson LE, and Robson MC. Long-term outcome study of growth factor-treated pressure ulcers. Am J Surg 181: 81-86, 2001.
29. Piquet P, Grau G, and Kossordo SD. Role of granulocyte-macrophage colony-stimulating factor in pulmonary fibrosis in mice by bleomycin. Exp Lung Res 19: 579-587, 1993.
30. Reed JA, Ikegami M, Cianciolo ER, Lu W, Cho PS, Hull W, Jobe AH, and Whitsett JA. Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice. Am J Physiol Lung Cell Mol Physiol 276: L556-L563, 1999.
31. Selman M, King TE, and Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 134: 136-151, 2001.
32. Smith W and Rollins T. Characteristics of rabbit anti-PGH synthase antibodies and use in immunochemistry. Methods Enzymol 86: 213-222, 1982.
33. Thrall R, McCormack J, Jack R, McReynolds R, and Ward P. Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin. Am J Pathol 95: 117-128, 1979.
34. 2 and to express cyclooxygenase-2. J Clin Invest 95: 1861-1868, 1995.
35. Xing Z, Ohkawara Y, Jordana M, Graham F, and Gauldie J. Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions. J Clin Invest 97: 1102-1110, 1996.
36. Xing Z, Tremblay G, Sime P, and Gauldie J. Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-B1 and myofibroblast accumulation. Am J Pathol 150: 59-66, 1997.
37. Young L and Adamson IY. Epithelial-fibroblast interactions in bleomycin-induced lung injury and repair. Environ Health Perspect 101: 56-61, 1993.
38. Zsengeller ZK, Reed JA, Bachurski CJ, LeVine AM, Forry-Schaudies S, Hirsch R, and Whitsett JA. Adenovirus-mediated granulocyte-macrophage colony-stimulating factor improves lung pathology of pulmonary alveolar proteinosis in granulocyte-macrophage colony-stimulating factor-deficient mice. Hum Gene Ther 9: 2101-2109, 1998.