Genetically engineered fusion of MAP-1 and factor H domains 1-5 generates a potent dual upstream inhibitor of both the lectin and alternative complement pathways

FASEB Journal

Volumn 29, Issue 12, 2015, Pages 4945-4955

  Nordmaj, Mie Anemone ^a   Munthe Fog, Lea ^a   Hein, Estrid ^a   Skjoedt, Mikkel Ole ^a   Garred, Peter ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Chimeric molecules; Complement therapeutics; Inflammation; Recombinant protein; Regulation

Indexed keywords

CHIMERIC PROTEIN; COMPLEMENT COMPONENT C3B; COMPLEMENT FACTOR H; FICOLIN; FICOLIN 1; FICOLIN 2; FICOLIN 3; HYBRID PROTEIN; LECTIN; LIGAND; MICROTUBULE ASSOCIATED PROTEIN 1; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; COMPLEMENT; MANNOSE BINDING LECTIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT DEPOSITION; COMPLEMENT INHIBITION; EC50; FEMALE; GENETIC CODE; GENETIC ENGINEERING; GENETIC TRANSFECTION; HUMAN; IC50; IN VITRO STUDY; NONHUMAN; OPTICAL DENSITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DETERMINATION; SIZE EXCLUSION CHROMATOGRAPHY; GENE VECTOR; GENETICS; METABOLISM; VALIDATION STUDY;

CHROMATOGRAPHY, GEL; COMPLEMENT FACTOR H; COMPLEMENT SYSTEM PROTEINS; GENETIC VECTORS; HUMANS; LECTINS; MANNOSE-BINDING LECTIN; RECOMBINANT FUSION PROTEINS;

EID: 84973434267     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-277103     Document Type: Article

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