Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein

Journal of Biological Chemistry

Volumn 279, Issue 20, 2004, Pages 21302-21311

  Larsen, Flemming ^a   Madsen, Hans O ^a   Sim, Robert B ^b   Koch, Claus ^c   Garred, Peter ^c  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; DISEASES; DNA; GENES; OLIGOMERS; PROTEINS;

MANNOSE BINDING LECTIN (MBL); MUTATIONS;

BIOCHEMISTRY;

COMPLEMENTARY DNA; MANNOSE BINDING LECTIN;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CHO CELL; COMPLEMENT ACTIVATION; COVALENT BOND; GENE; GENE MUTATION; GENETIC CODE; GENETIC DISORDER; HUMAN; LIGAND BINDING; MBL2 GENE; MOLECULAR CLONING; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CHO CELLS; CLONING, MOLECULAR; CODON; COMPLEMENT ACTIVATION; CRICETINAE; DISEASE; HUMANS; MACROMOLECULAR SUBSTANCES; MANNOSE-BINDING LECTIN; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; TRANSFECTION; VARIATION (GENETICS);

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

EID: 2442676733     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400520200     Document Type: Article

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