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Volumn 59, Issue 5, 2015, Pages 391-399

The role of melatonin in diabetes: Therapeutic implications

Author keywords

Beta cells; Calcium; Circadian rhythm; Diabetes; Insulin; Melatonin

Indexed keywords

GLUCOSE; INSULIN; MELATONIN; MELATONIN RECEPTOR;

EID: 84973427393     PISSN: 23593997     EISSN: 23594292     Source Type: Journal    
DOI: 10.1590/2359-3997000000098     Document Type: Review
Times cited : (95)

References (97)
  • 2
    • 68949148762 scopus 로고    scopus 로고
    • Sleep and society: An epidemiological perspective
    • Bixler E. Sleep and society: an epidemiological perspective. Sleep Med. 2009;10:S3-6.
    • (2009) Sleep Med , vol.10 , pp. S3-S6
    • Bixler, E.1
  • 3
    • 63149163425 scopus 로고    scopus 로고
    • Adverse metabolic and cardiovascular consequences of circadian misalignment
    • Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009;106(11):4453-8.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.11 , pp. 4453-4458
    • Scheer, F.A.1    Hilton, M.F.2    Mantzoros, C.S.3    Shea, S.A.4
  • 4
    • 0025758136 scopus 로고
    • Pineal melatonin: Cell biology of its synthesis and of its physiological interactions
    • Reiter RJ. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev. 1991;12(2):151-80.
    • (1991) Endocr Rev , vol.12 , Issue.2 , pp. 151-180
    • Reiter, R.J.1
  • 5
    • 0035049581 scopus 로고    scopus 로고
    • Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat
    • Stefulj J, Hörtner M, Ghosh M, Schauenstein K, Rinner I, Wölfler A, et al. Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat. J Pineal Res. 2001;30(4):243-7.
    • (2001) J Pineal Res , vol.30 , Issue.4 , pp. 243-247
    • Stefulj, J.1    Hörtner, M.2    Ghosh, M.3    Schauenstein, K.4    Rinner, I.5    Wölfler, A.6
  • 6
    • 33645100557 scopus 로고    scopus 로고
    • Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status
    • Peschke E, Frese T, Chankiewitz E, Peschke D, Preiss U, Schneyer U, et al. Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status. J Pineal Res. 2006;40(2):135-43.
    • (2006) J Pineal Res , vol.40 , Issue.2 , pp. 135-143
    • Peschke, E.1    Frese, T.2    Chankiewitz, E.3    Peschke, D.4    Preiss, U.5    Schneyer, U.6
  • 7
    • 0036164051 scopus 로고    scopus 로고
    • Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity
    • Nishida S, Segawa T, Murai I, Nakagawa S. Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity. J Pineal Res. 2002;32(1):26-33.
    • (2002) J Pineal Res , vol.32 , Issue.1 , pp. 26-33
    • Nishida, S.1    Segawa, T.2    Murai, I.3    Nakagawa, S.4
  • 8
    • 58049198441 scopus 로고    scopus 로고
    • Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine β-cell function
    • Staiger H, Machicao F, Schäfer SA, Kirchhoff K, Kantartzis K, Guthoff M, et al. Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine β-cell function. PLoS One. 2008;3(12):e3962.
    • (2008) Plos One , vol.3 , Issue.12
    • Staiger, H.1    Machicao, F.2    Schäfer, S.A.3    Kirchhoff, K.4    Kantartzis, K.5    Guthoff, M.6
  • 9
    • 58149175143 scopus 로고    scopus 로고
    • A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    • Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, Sparsø T, Holmkvist J, Marchand M, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet. 2008;41(1):89-94.
    • (2008) Nat Genet , vol.41 , Issue.1 , pp. 89-94
    • Bouatia-Naji, N.1    Bonnefond, A.2    Cavalcanti-Proença, C.3    Sparsø, T.4    Holmkvist, J.5    Marchand, M.6
  • 10
    • 58149175669 scopus 로고    scopus 로고
    • Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
    • Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spégel P, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 2008;41(1):82-8.
    • (2008) Nat Genet , vol.41 , Issue.1 , pp. 82-88
    • Lyssenko, V.1    Nagorny, C.L.2    Erdos, M.R.3    Wierup, N.4    Jonsson, A.5    Spégel, P.6
  • 12
    • 66649121685 scopus 로고    scopus 로고
    • G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release Studies Involving 19,605 Europeans
    • Sparsø T, Bonnefond A, Andersson E, Bouatia-Naji N, Holmkvist J, Wegner L, et al. G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release Studies Involving 19,605 Europeans. Diabetes. 2009;58(6):1450-6.
    • (2009) Diabetes , vol.58 , Issue.6 , pp. 1450-1456
    • Sparsø, T.1    Bonnefond, A.2    Andersson, E.3    Bouatia-Naji, N.4    Holmkvist, J.5    Wegner, L.6
  • 13
    • 64149094603 scopus 로고    scopus 로고
    • A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals
    • Rönn T, Wen J, Yang Z, Lu B, Du Y, Groop L, et al. A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia. 2009;52(5):830-3.
    • (2009) Diabetologia , vol.52 , Issue.5 , pp. 830-833
    • Rönn, T.1    Wen, J.2    Yang, Z.3    Lu, B.4    Du, Y.5    Groop, L.6
  • 14
    • 0038621817 scopus 로고    scopus 로고
    • Generation of the melatonin endocrine message in mammals: A review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters
    • Simonneaux V, Ribelayga C. Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev. 2003;55(2):325-95.
    • (2003) Pharmacol Rev , vol.55 , Issue.2 , pp. 325-395
    • Simonneaux, V.1    Ribelayga, C.2
  • 15
    • 84989205845 scopus 로고
    • Melatonin and the mammalian pineal gland
    • Arendt J. Melatonin and the mammalian pineal gland: Springer; 1995.
    • (1995) Springer
    • Arendt, J.1
  • 16
    • 0345464120 scopus 로고
    • Enzymatic O-methylation of N-acetylserotonin to melatonin
    • Axelrod J, Weissbach H. Enzymatic O-methylation of N-acetylserotonin to melatonin. Science. 1960;131(3409):1312.
    • (1960) Science , vol.131 , Issue.3409 , pp. 1312
    • Axelrod, J.1    Weissbach, H.2
  • 17
    • 1842405956 scopus 로고    scopus 로고
    • Relationship between heat loss and sleepiness: Effects of postural change and melatonin administration
    • Kräuchi K, Cajochen C, Wirz-Justice A. A relationship between heat loss and sleepiness: effects of postural change and melatonin administration. J Appl Physiol (1985). 1997;83(1):134-9.
    • (1997) J Appl Physiol (1985) , vol.83 , Issue.1 , pp. 134-139
    • Kräuchi, K.1    Cajochen, C.2    Wirz-Justice, A.A.3
  • 18
    • 0029797433 scopus 로고    scopus 로고
    • Non-24-hour sleep-wake syndrome in a sighted man: Circadian rhythm studies and efficacy of melatonin treatment
    • McArthur AJ, Lewy AJ, Sack RL. Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin treatment. Sleep. 1996;19(7):544-53.
    • (1996) Sleep , vol.19 , Issue.7 , pp. 544-553
    • McArthur, A.J.1    Lewy, A.J.2    Sack, R.L.3
  • 19
    • 0033768749 scopus 로고    scopus 로고
    • Actions of melatonin in the reduction of oxidative stress
    • Reiter RJ, Tan D-x, Osuna C, Gitto E. Actions of melatonin in the reduction of oxidative stress. J Biomed Sci. 2000;7(6):444-58.
    • (2000) J Biomed Sci , vol.7 , Issue.6 , pp. 444-458
    • Reiter, R.J.1    Tan, D.-X.2    Osuna, C.3    Gitto, E.4
  • 20
    • 51649105998 scopus 로고    scopus 로고
    • Novel bromomelatonin derivatives as potentially effective drugs to treat bone diseases
    • Suzuki N, Somei M, Seki A, Reiter RJ, Hattori A. Novel bromomelatonin derivatives as potentially effective drugs to treat bone diseases. J Pineal Res. 2008;45(3):229-34.
    • (2008) J Pineal Res , vol.45 , Issue.3 , pp. 229-234
    • Suzuki, N.1    Somei, M.2    Seki, A.3    Reiter, R.J.4    Hattori, A.5
  • 22
    • 0031047713 scopus 로고    scopus 로고
    • The diffuse neuroendocrine system and extrapineal melatonin
    • Kvetnoy I, Sandvik A, Waldum H. The diffuse neuroendocrine system and extrapineal melatonin. J Mol Endocrinol. 1997;18(1):1-3.
    • (1997) J Mol Endocrinol , vol.18 , Issue.1 , pp. 1-3
    • Kvetnoy, I.1    Sandvik, A.2    Waldum, H.3
  • 23
    • 36849034462 scopus 로고    scopus 로고
    • Melatonin, endocrine pancreas and diabetes
    • Peschke E. Melatonin, endocrine pancreas and diabetes. J Pineal Res. 2008;44(1):26-40.
    • (2008) J Pineal Res , vol.44 , Issue.1 , pp. 26-40
    • Peschke, E.1
  • 26
    • 0034812402 scopus 로고    scopus 로고
    • Functional expression of MT2 (Mel1b) melatonin receptors in human PAZ6 adipocytes
    • Brydon L, Petit L, Delagrange P, Strosberg AD, Jockers R. Functional expression of MT2 (Mel1b) melatonin receptors in human PAZ6 adipocytes. Endocrinology. 2001;142(10):4264-71.
    • (2001) Endocrinology , vol.142 , Issue.10 , pp. 4264-4271
    • Brydon, L.1    Petit, L.2    Delagrange, P.3    Strosberg, A.D.4    Jockers, R.5
  • 27
    • 33745553890 scopus 로고    scopus 로고
    • Melatonin stimulates glucose transport via insulin receptor substrate-1/ phosphatidylinositol 3-kinase pathway in C2C12 murine skeletal muscle cells
    • Ha E, Yim SV, Chung JH, Yoon KS, Kang I, Cho YH, et al. Melatonin stimulates glucose transport via insulin receptor substrate-1/ phosphatidylinositol 3-kinase pathway in C2C12 murine skeletal muscle cells. J Pineal Res. 2006;41(1):67-72.
    • (2006) J Pineal Res , vol.41 , Issue.1 , pp. 67-72
    • Ha, E.1    Yim, S.V.2    Chung, J.H.3    Yoon, K.S.4    Kang, I.5    Cho, Y.H.6
  • 28
    • 0035200294 scopus 로고    scopus 로고
    • Modulation of blood glucose by melatonin: A direct action on melatonin receptors in mouse hepatocytes
    • Poon A, Choy E, Pang S. Modulation of blood glucose by melatonin: a direct action on melatonin receptors in mouse hepatocytes. Neurosignals. 2001;10(6):367-79.
    • (2001) Neurosignals , vol.10 , Issue.6 , pp. 367-379
    • Poon, A.1    Choy, E.2    Pang, S.3
  • 29
    • 0035991404 scopus 로고    scopus 로고
    • Mammalian melatonin receptors: Molecular biology and signal transduction
    • von Gall C, Stehle JH, Weaver DR. Mammalian melatonin receptors: molecular biology and signal transduction. Cell Tissue Res. 2002;309(1):151-62.
    • (2002) Cell Tissue Res , vol.309 , Issue.1 , pp. 151-162
    • Von Gall, C.1    Stehle, J.H.2    Weaver, D.R.3
  • 30
    • 0028018966 scopus 로고
    • Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
    • Reppert SM, Weaver DR, Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron. 1994;13(5):1177-85.
    • (1994) Neuron , vol.13 , Issue.5 , pp. 1177-1185
    • Reppert, S.M.1    Weaver, D.R.2    Ebisawa, T.3
  • 31
    • 0029115639 scopus 로고
    • Molecular characterization of a second melatonin receptor expressed in human retina and brain: The Mel1b melatonin receptor
    • Reppert SM, Godson C, Mahle CD, Weaver DR, Slaugenhaupt SA, Gusella JF. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc Natl Acad Sci U S A. 1995;92(19):8734-8.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.19 , pp. 8734-8738
    • Reppert, S.M.1    Godson, C.2    Mahle, C.D.3    Weaver, D.R.4    Slaugenhaupt, S.A.5    Gusella, J.F.6
  • 32
    • 27644449587 scopus 로고    scopus 로고
    • Functional MT1 and MT2 melatonin receptors in mammals
    • Dubocovich ML, Markowska M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine. 2005;27(2):101-10.
    • (2005) Endocrine , vol.27 , Issue.2 , pp. 101-110
    • Dubocovich, M.L.1    Markowska, M.2
  • 33
    • 0034071906 scopus 로고    scopus 로고
    • Evidence for a melatonin receptor within pancreatic islets of neonate rats: Functional, autoradiographic, and molecular investigations
    • Peschke E, Fauteck JD, Mußhoff U, Schmidt F, Beckmann A, Peschke D. Evidence for a melatonin receptor within pancreatic islets of neonate rats: functional, autoradiographic, and molecular investigations. J Pineal Res. 2000;28(3):156-64.
    • (2000) J Pineal Res , vol.28 , Issue.3 , pp. 156-164
    • Peschke, E.1    Fauteck, J.D.2    Mußhoff, U.3    Schmidt, F.4    Beckmann, A.5    Peschke, D.6
  • 34
    • 0031827222 scopus 로고    scopus 로고
    • Evidence for a circadian rhythm of insulin release from perifused rat pancreatic islets
    • Peschke E, Peschke D. Evidence for a circadian rhythm of insulin release from perifused rat pancreatic islets. Diabetologia. 1998;41(9):1085-92.
    • (1998) Diabetologia , vol.41 , Issue.9 , pp. 1085-1092
    • Peschke, E.1    Peschke, D.2
  • 35
    • 33845537397 scopus 로고    scopus 로고
    • Evidence for the expression of both the MT1- and in addition, the MT2-melatonin receptor
    • Muhlbauer E, Peschke E. Evidence for the expression of both the MT1- and in addition, the MT2-melatonin receptor, in the rat pancreas, islet and beta-cell. J Pineal Res. 2007;42(1):105-6.
    • (2007) J Pineal Res , vol.42 , Issue.1 , pp. 105-106
    • Muhlbauer, E.1    Peschke, E.2
  • 36
    • 84878347362 scopus 로고    scopus 로고
    • Autonomous and self-sustained circadian oscillators displayed in human islet cells
    • Pulimeno P, Mannic T, Sage D, Giovannoni L, Salmon P, Lemeille S, et al. Autonomous and self-sustained circadian oscillators displayed in human islet cells. Diabetologia. 2013;56(3):497-507.
    • (2013) Diabetologia , vol.56 , Issue.3 , pp. 497-507
    • Pulimeno, P.1    Mannic, T.2    Sage, D.3    Giovannoni, L.4    Salmon, P.5    Lemeille, S.6
  • 37
    • 33749031807 scopus 로고    scopus 로고
    • Molecular components of the mammalian circadian clock
    • Ko CH, Takahashi JS. Molecular components of the mammalian circadian clock. Hum Mol Genet. 2006;15(suppl 2):R271-R7.
    • (2006) Hum Mol Genet , vol.15 , pp. R271-R277
    • Ko, C.H.1    Takahashi, J.S.2
  • 39
    • 0030729774 scopus 로고    scopus 로고
    • The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior
    • Lopez-Molina L, Conquet F, Dubois-Dauphin M, Schibler U. The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior. EMBO J. 1997;16(22):6762-71.
    • (1997) EMBO J , vol.16 , Issue.22 , pp. 6762-6771
    • Lopez-Molina, L.1    Conquet, F.2    Dubois-Dauphin, M.3    Schibler, U.4
  • 40
    • 0037178787 scopus 로고    scopus 로고
    • The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
    • Preitner N, Damiola F, Lopez-Molina L, Zakany J, Duboule D, Albrecht U, et al. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 2002;110(2):251-60.
    • (2002) Cell , vol.110 , Issue.2 , pp. 251-260
    • Preitner, N.1    Damiola, F.2    Lopez-Molina, L.3    Zakany, J.4    Duboule, D.5    Albrecht, U.6
  • 41
    • 82055164281 scopus 로고    scopus 로고
    • A clock ticks in pancreatic beta cells
    • Yoshino J, Imai S. A clock ticks in pancreatic beta cells. Cell metabolism. 2010;12(2):107-8.
    • (2010) Cell Metabolism , vol.12 , Issue.2 , pp. 107-108
    • Yoshino, J.1    Imai, S.2
  • 42
    • 78649687209 scopus 로고    scopus 로고
    • Circadian integration of metabolism and energetics
    • Bass J, Takahashi JS. Circadian integration of metabolism and energetics. Science. 2010;330(6009):1349-54.
    • (2010) Science , vol.330 , Issue.6009 , pp. 1349-1354
    • Bass, J.1    Takahashi, J.S.2
  • 44
    • 84905059422 scopus 로고    scopus 로고
    • The effects of light at night on circadian clocks and metabolism
    • Fonken LK, Nelson RJ. The effects of light at night on circadian clocks and metabolism. Endocr Rev. 2014;35(4):648-70.
    • (2014) Endocr Rev , vol.35 , Issue.4 , pp. 648-670
    • Fonken, L.K.1    Nelson, R.J.2
  • 45
    • 77954848215 scopus 로고    scopus 로고
    • Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
    • Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 2010;466(7306):627-31.
    • (2010) Nature , vol.466 , Issue.7306 , pp. 627-631
    • Marcheva, B.1    Ramsey, K.M.2    Buhr, E.D.3    Kobayashi, Y.4    Su, H.5    Ko, C.H.6
  • 46
    • 0036720357 scopus 로고    scopus 로고
    • Receptor (MT1) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1
    • Peschke E, Mühlbauer E, Mußhoff U, Csernus VJ, Chankiewitz E, Peschke D. Receptor (MT1) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1. J Pineal Res. 2002;33(2):63-71.
    • (2002) J Pineal Res , vol.33 , Issue.2 , pp. 63-71
    • Peschke, E.1    Mühlbauer, E.2    Mußhoff, U.3    Csernus, V.J.4    Chankiewitz, E.5    Peschke, D.6
  • 47
    • 0037077043 scopus 로고    scopus 로고
    • Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: Potential role in incretin-mediated cell function by sensitization of cAMP signaling
    • Kemp DM, Ubeda M, Habener JF. Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling. Mol Cell Endocrinol. 2002;191(2):157-66.
    • (2002) Mol Cell Endocrinol , vol.191 , Issue.2 , pp. 157-166
    • Kemp, D.M.1    Ubeda, M.2    Habener, J.F.3
  • 48
    • 0036720357 scopus 로고    scopus 로고
    • Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1
    • Peschke E, Muhlbauer E, Musshoff U, Csernus VJ, Chankiewitz E, Peschke D. Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1. J Pineal Res. 2002;33(2):63-71.
    • (2002) J Pineal Res , vol.33 , Issue.2 , pp. 63-71
    • Peschke, E.1    Muhlbauer, E.2    Musshoff, U.3    Csernus, V.J.4    Chankiewitz, E.5    Peschke, D.6
  • 49
    • 51649124759 scopus 로고    scopus 로고
    • Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells
    • Stumpf I, Muhlbauer E, Peschke E. Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells. J Pineal Res. 2008;45(3):318-27.
    • (2008) J Pineal Res , vol.45 , Issue.3 , pp. 318-327
    • Stumpf, I.1    Muhlbauer, E.2    Peschke, E.3
  • 50
    • 59149091752 scopus 로고    scopus 로고
    • Modulation of the cGMP signaling pathway by melatonin in pancreatic beta-cells
    • Stumpf I, Bazwinsky I, Peschke E. Modulation of the cGMP signaling pathway by melatonin in pancreatic beta-cells. J Pineal Res. 2009;46(2):140-7.
    • (2009) J Pineal Res , vol.46 , Issue.2 , pp. 140-147
    • Stumpf, I.1    Bazwinsky, I.2    Peschke, E.3
  • 51
    • 25144453239 scopus 로고    scopus 로고
    • Melatonin stimulates inositol-1,4,5-trisphosphate and Ca2+ release from INS1 insulinoma cells
    • Bach AG, Wolgast S, Muhlbauer E, Peschke E. Melatonin stimulates inositol-1,4,5-trisphosphate and Ca2+ release from INS1 insulinoma cells. J Pineal Res. 2005;39(3):316-23.
    • (2005) J Pineal Res , vol.39 , Issue.3 , pp. 316-323
    • Bach, A.G.1    Wolgast, S.2    Muhlbauer, E.3    Peschke, E.4
  • 52
    • 0033346394 scopus 로고    scopus 로고
    • Dual signaling of human Mel1a melatonin receptors via G(I2), G(i3), and G(q/11) proteins
    • Brydon L, Roka F, Petit L, de Coppet P, Tissot M, Barrett P, et al. Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. Mol Endocrinol. 1999;13(12):2025-38.
    • (1999) Mol Endocrinol , vol.13 , Issue.12 , pp. 2025-2038
    • Brydon, L.1    Roka, F.2    Petit, L.3    De Coppet, P.4    Tissot, M.5    Barrett, P.6
  • 53
    • 33645098511 scopus 로고    scopus 로고
    • Parallel signaling pathways of melatonin in the pancreatic beta-cell
    • Peschke E, Bach AG, Muhlbauer E. Parallel signaling pathways of melatonin in the pancreatic beta-cell. J Pineal Res. 2006;40(2):184-91.
    • (2006) J Pineal Res , vol.40 , Issue.2 , pp. 184-191
    • Peschke, E.1    Bach, A.G.2    Muhlbauer, E.3
  • 54
    • 85047676942 scopus 로고    scopus 로고
    • The Mel1a melatonin receptor is coupled to parallel signal transduction pathways
    • Godson C, Reppert SM. The Mel1a melatonin receptor is coupled to parallel signal transduction pathways. Endocrinology. 1997;138(1):397-404.
    • (1997) Endocrinology , vol.138 , Issue.1 , pp. 397-404
    • Godson, C.1    Reppert, S.M.2
  • 58
    • 84890129569 scopus 로고    scopus 로고
    • Influence of melatonin receptor signalling on parameters involved in blood glucose regulation
    • Bazwinsky-Wutschke I, Bieseke L, Muhlbauer E, Peschke E. Influence of melatonin receptor signalling on parameters involved in blood glucose regulation. J Pineal Res. 2014;56(1):82-96.
    • (2014) J Pineal Res , vol.56 , Issue.1 , pp. 82-96
    • Bazwinsky-Wutschke, I.1    Bieseke, L.2    Muhlbauer, E.3    Peschke, E.4
  • 59
    • 34547112397 scopus 로고    scopus 로고
    • Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin
    • Hussain SA, Khadim HM, Khalaf BH, Ismail SH, Hussein KI, Sahib AS. Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin. Saudi Med J. 2006;27(10):1483-8.
    • (2006) Saudi Med J , vol.27 , Issue.10 , pp. 1483-1488
    • Hussain, S.A.1    Khadim, H.M.2    Khalaf, B.H.3    Ismail, S.H.4    Hussein, K.I.5    Sahib, A.S.6
  • 60
    • 0035072930 scopus 로고    scopus 로고
    • Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women
    • Cagnacci A, Arangino S, Renzi A, Paoletti AM, Melis GB, Cagnacci P, et al. Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women. Clin Endocrinol (Oxf). 2001;54(3):339-46.
    • (2001) Clin Endocrinol (Oxf) , vol.54 , Issue.3 , pp. 339-346
    • Cagnacci, A.1    Arangino, S.2    Renzi, A.3    Paoletti, A.M.4    Melis, G.B.5    Cagnacci, P.6
  • 61
    • 58149175143 scopus 로고    scopus 로고
    • A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    • Bouatia-Naji N, Bonnefond A, Cavalcanti-Proenca C, Sparso T, Holmkvist J, Marchand M, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet. 2009;41(1):89-94.
    • (2009) Nat Genet , vol.41 , Issue.1 , pp. 89-94
    • Bouatia-Naji, N.1    Bonnefond, A.2    Cavalcanti-Proenca, C.3    Sparso, T.4    Holmkvist, J.5    Marchand, M.6
  • 62
    • 79952574655 scopus 로고    scopus 로고
    • Melatonin stimulates glucagon secretion in vitro and in vivo
    • Bahr I, Muhlbauer E, Schucht H, Peschke E. Melatonin stimulates glucagon secretion in vitro and in vivo. J Pineal Res. 2011;50(3):336-44.
    • (2011) J Pineal Res , vol.50 , Issue.3 , pp. 336-344
    • Bahr, I.1    Muhlbauer, E.2    Schucht, H.3    Peschke, E.4
  • 63
    • 0037077043 scopus 로고    scopus 로고
    • Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: Potential role in incretin-mediated cell function by sensitization of cAMP signaling
    • Kemp DM, Ubeda M, Habener JF. Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling. Mol Cell Endocrinol. 2002;191(2):157-66.
    • (2002) Mol Cell Endocrinol , vol.191 , Issue.2 , pp. 157-166
    • Kemp, D.M.1    Ubeda, M.2    Habener, J.F.3
  • 65
    • 79954417344 scopus 로고    scopus 로고
    • Distribution of melatonin receptors in murine pancreatic islets
    • Nagorny CL, Sathanoori R, Voss U, Mulder H, Wierup N. Distribution of melatonin receptors in murine pancreatic islets. J Pineal Res. 2011;50(4):412-7.
    • (2011) J Pineal Res , vol.50 , Issue.4 , pp. 412-417
    • Nagorny, C.L.1    Sathanoori, R.2    Voss, U.3    Mulder, H.4    Wierup, N.5
  • 67
    • 0032994093 scopus 로고    scopus 로고
    • Diurnal variations in insulin secretion and K+ permeability in isolated rat islets
    • Delattre E, Cipolla-Neto J, Boschero AC. Diurnal variations in insulin secretion and K+ permeability in isolated rat islets. Clin Exp Pharmacol Physiol. 1999;26(7):505-10.
    • (1999) Clin Exp Pharmacol Physiol , vol.26 , Issue.7 , pp. 505-510
    • Delattre, E.1    Cipolla-Neto, J.2    Boschero, A.C.3
  • 69
    • 36849080350 scopus 로고    scopus 로고
    • Activation of insulin and IGF-1 signaling pathways by melatonin through MT1 receptor in isolated rat pancreatic islets
    • Picinato MC, Hirata AE, Cipolla-Neto J, Curi R, Carvalho CR, Anhe GF, et al. Activation of insulin and IGF-1 signaling pathways by melatonin through MT1 receptor in isolated rat pancreatic islets. J Pineal Res. 2008;44(1):88-94.
    • (2008) J Pineal Res , vol.44 , Issue.1 , pp. 88-94
    • Picinato, M.C.1    Hirata, A.E.2    Cipolla-Neto, J.3    Curi, R.4    Carvalho, C.R.5    Anhe, G.F.6
  • 70
    • 0031865423 scopus 로고    scopus 로고
    • Diurnal rhythms in plasma glucose, insulin, growth hormone and melatonin levels in fasted and hyperglycaemic rats
    • Bizot-Espiard JG, Double A, Guardiola-Lemaitre B, Delagrange P, Ktorza A, Penicaud L. Diurnal rhythms in plasma glucose, insulin, growth hormone and melatonin levels in fasted and hyperglycaemic rats. Diabetes Metab. 1998;24(3):235-40.
    • (1998) Diabetes Metab , vol.24 , Issue.3 , pp. 235-240
    • Bizot-Espiard, J.G.1    Double, A.2    Guardiola-Lemaitre, B.3    Delagrange, P.4    Ktorza, A.5    Penicaud, L.6
  • 71
    • 0035178919 scopus 로고    scopus 로고
    • Role for the pineal and melatonin in glucose homeostasis: Pinealectomy increases night-time glucose concentrations
    • la Fleur SE, Kalsbeek A, Wortel J, van der Vliet J, Buijs RM. Role for the pineal and melatonin in glucose homeostasis: pinealectomy increases night-time glucose concentrations. J Neuroendocrinol. 2001;13(12):1025-32.
    • (2001) J Neuroendocrinol , vol.13 , Issue.12 , pp. 1025-1032
    • La Fleur, S.E.1    Kalsbeek, A.2    Wortel, J.3    Van Der Vliet, J.4    Buijs, R.M.5
  • 72
    • 84875418835 scopus 로고    scopus 로고
    • Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon
    • Peschke E, Bahr I, Muhlbauer E. Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon. Int J Mol Sci. 2013;14(4):6981-7015.
    • (2013) Int J Mol Sci , vol.14 , Issue.4 , pp. 6981-7015
    • Peschke, E.1    Bahr, I.2    Muhlbauer, E.3
  • 73
    • 77956095525 scopus 로고    scopus 로고
    • Removal of melatonin receptor type 1 induces insulin resistance in the mouse
    • Contreras-Alcantara S, Baba K, Tosini G. Removal of melatonin receptor type 1 induces insulin resistance in the mouse. Obesity (Silver Spring). 2010;18(9):1861-3.
    • (2010) Obesity (Silver Spring) , vol.18 , Issue.9 , pp. 1861-1863
    • Contreras-Alcantara, S.1    Baba, K.2    Tosini, G.3
  • 74
    • 58149175669 scopus 로고    scopus 로고
    • Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
    • Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spegel P, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 2009;41(1):82-8.
    • (2009) Nat Genet , vol.41 , Issue.1 , pp. 82-88
    • Lyssenko, V.1    Nagorny, C.L.2    Erdos, M.R.3    Wierup, N.4    Jonsson, A.5    Spegel, P.6
  • 75
    • 64149094603 scopus 로고    scopus 로고
    • A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals
    • Ronn T, Wen J, Yang Z, Lu B, Du Y, Groop L, et al. A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia. 2009;52(5):830-3.
    • (2009) Diabetologia , vol.52 , Issue.5 , pp. 830-833
    • Ronn, T.1    Wen, J.2    Yang, Z.3    Lu, B.4    Du, Y.5    Groop, L.6
  • 76
    • 77950641869 scopus 로고    scopus 로고
    • MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai
    • Liu C, Wu Y, Li H, Qi Q, Langenberg C, Loos RJ, et al. MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai. BMC Med Genet. 2010;11:59.
    • (2010) BMC Med Genet , vol.11 , pp. 59
    • Liu, C.1    Wu, Y.2    Li, H.3    Qi, Q.4    Langenberg, C.5    Loos, R.J.6
  • 77
    • 77955357997 scopus 로고    scopus 로고
    • Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects
    • Tam CH, Ho JS, Wang Y, Lee HM, Lam VK, Germer S, et al. Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects. PLoS One. 2010;5(7):e11428.
    • (2010) Plos One , vol.5 , Issue.7
    • Tam, C.H.1    Ho, J.S.2    Wang, Y.3    Lee, H.M.4    Lam, V.K.5    Germer, S.6
  • 78
    • 77955352048 scopus 로고    scopus 로고
    • Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion
    • Hu C, Zhang R, Wang C, Yu W, Lu J, Ma X, et al. Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion. PLoS One. 2010;5(7):e11761.
    • (2010) Plos One , vol.5 , Issue.7 , pp. e11761
    • Hu, C.1    Zhang, R.2    Wang, C.3    Yu, W.4    Lu, J.5    Ma, X.6
  • 79
    • 77951278305 scopus 로고    scopus 로고
    • Two susceptible diabetogenic variants near
    • Kan MY, Zhou DZ, Zhang D, Zhang Z, Chen Z, Yang YF, et al. Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort. Diabet Med. 2010;27(5):598-602.
    • (2010) Diabet Med , vol.27 , Issue.5 , pp. 598-602
    • Kan, M.Y.1    Zhou, D.Z.2    Zhang, D.3    Zhang, Z.4    Chen, Z.5    Yang, Y.F.6
  • 80
    • 79951488022 scopus 로고    scopus 로고
    • Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome
    • Li C, Shi Y, You L, Wang L, Chen ZJ. Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome. Mol Hum Reprod. 2011;17(3):193-8.
    • (2011) Mol Hum Reprod , vol.17 , Issue.3 , pp. 193-198
    • Li, C.1    Shi, Y.2    You, L.3    Wang, L.4    Chen, Z.J.5
  • 81
    • 77949300137 scopus 로고    scopus 로고
    • Common variants at the GCK, GCKR, G6PC2ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations
    • Takeuchi F, Katsuya T, Chakrewarthy S, Yamamoto K, Fujioka A, Serizawa M, et al. Common variants at the GCK, GCKR, G6PC2ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations. Diabetologia. 2010;53(2):299-308.
    • (2010) Diabetologia , vol.53 , Issue.2 , pp. 299-308
    • Takeuchi, F.1    Katsuya, T.2    Chakrewarthy, S.3    Yamamoto, K.4    Fujioka, A.5    Serizawa, M.6
  • 82
    • 84863622669 scopus 로고    scopus 로고
    • Association of genetic variants of melatonin receptor 1B with gestational plasma glucose level and risk of glucose intolerance in pregnant Chinese women
    • Liao S, Liu Y, Tan Y, Gan L, Mei J, Song W, et al. Association of genetic variants of melatonin receptor 1B with gestational plasma glucose level and risk of glucose intolerance in pregnant Chinese women. PLoS One. 2012;7(7):e40113.
    • (2012) Plos One , vol.7 , Issue.7
    • Liao, S.1    Liu, Y.2    Tan, Y.3    Gan, L.4    Mei, J.5    Song, W.6
  • 83
    • 84870597076 scopus 로고    scopus 로고
    • Association between the melatonin receptor 1B gene polymorphism on the risk of type 2 diabetes, impaired glucose regulation: A metaanalysis
    • Xia Q, Chen ZX, Wang YC, Ma YS, Zhang F, Che W, et al. Association between the melatonin receptor 1B gene polymorphism on the risk of type 2 diabetes, impaired glucose regulation: a metaanalysis. PLoS One. 2012;7(11):e50107.
    • (2012) Plos One , vol.7 , Issue.11
    • Xia, Q.1    Chen, Z.X.2    Wang, Y.C.3    Ma, Y.S.4    Zhang, F.5    Che, W.6
  • 84
    • 84934945720 scopus 로고    scopus 로고
    • MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women
    • Vejrazkova D, Lukasova P. MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women. Int J Endocrinol. 2014;2014:508923.
    • (2014) Int J Endocrinol , vol.2014
    • Vejrazkova, D.1    Lukasova, P.2
  • 86
    • 58049198441 scopus 로고    scopus 로고
    • Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function
    • Staiger H, Machicao F, Schafer SA, Kirchhoff K, Kantartzis K, Guthoff M, et al. Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. PLoS One. 2008;3(12):e3962.
    • (2008) Plos One , vol.3 , Issue.12
    • Staiger, H.1    Machicao, F.2    Schafer, S.A.3    Kirchhoff, K.4    Kantartzis, K.5    Guthoff, M.6
  • 87
    • 84907930175 scopus 로고    scopus 로고
    • Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening
    • Rubio-Sastre P, Scheer FA, Gomez-Abellan P, Madrid JA, Garaulet M. Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. Sleep. 2014;37(10):1715-9.
    • (2014) Sleep , vol.37 , Issue.10 , pp. 1715-1719
    • Rubio-Sastre, P.1    Scheer, F.A.2    Gomez-Abellan, P.3    Madrid, J.A.4    Garaulet, M.5
  • 88
    • 77954471399 scopus 로고    scopus 로고
    • A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects
    • Donga E, van Dijk M, van Dijk JG, Biermasz NR, Lammers GJ, van Kralingen KW, et al. A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects. J Clin Endocrinol Metab. 2010;95(6):2963-8.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.6 , pp. 2963-2968
    • Donga, E.1    Van Dijk, M.2    Van Dijk, J.G.3    Biermasz, N.R.4    Lammers, G.J.5    Van Kralingen, K.W.6
  • 89
    • 33744971827 scopus 로고    scopus 로고
    • Sleep duration as a risk factor for the development of type 2 diabetes
    • Yaggi HK, Araujo AB, McKinlay JB. Sleep duration as a risk factor for the development of type 2 diabetes. Diabetes Care. 2006;29(3):657-61.
    • (2006) Diabetes Care , vol.29 , Issue.3 , pp. 657-661
    • Yaggi, H.K.1    Araujo, A.B.2    McKinlay, J.B.3
  • 91
    • 79953743149 scopus 로고    scopus 로고
    • Melatonin and the metabolic syndrome: Physiopathologic and therapeutical implications
    • Cardinali DP, Cano P, Jimenez-Ortega V, Esquifino AI. Melatonin and the metabolic syndrome: physiopathologic and therapeutical implications. Neuroendocrinology. 2011;93(3):133-42.
    • (2011) Neuroendocrinology , vol.93 , Issue.3 , pp. 133-142
    • Cardinali, D.P.1    Cano, P.2    Jimenez-Ortega, V.3    Esquifino, A.I.4
  • 92
    • 77953212878 scopus 로고    scopus 로고
    • MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans
    • Andersson EA, Holst B, Sparso T, Grarup N, Banasik K, Holmkvist J, et al. MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. Diabetes. 2010;59(6):1539-48.
    • (2010) Diabetes , vol.59 , Issue.6 , pp. 1539-1548
    • Andersson, E.A.1    Holst, B.2    Sparso, T.3    Grarup, N.4    Banasik, K.5    Holmkvist, J.6
  • 93
    • 66649121685 scopus 로고    scopus 로고
    • G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: Studies involving 19,605 Europeans
    • Sparso T, Bonnefond A, Andersson E, Bouatia-Naji N, Holmkvist J, Wegner L, et al. G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans. Diabetes. 2009;58(6):1450-6.
    • (2009) Diabetes , vol.58 , Issue.6 , pp. 1450-1456
    • Sparso, T.1    Bonnefond, A.2    Andersson, E.3    Bouatia-Naji, N.4    Holmkvist, J.5    Wegner, L.6
  • 94
    • 0029741066 scopus 로고    scopus 로고
    • Evidence for a circadianrhythm of insulin secretion
    • Boden G, Ruiz J, Urbain JL, Chen X. Evidence for a circadian rhythm of insulin secretion. Am J Physiol. 1996;271(2 Pt 1):E246-52.
    • (1996) Sleep Med Rev , vol.271 , Issue.2 , pp. E246-E252
    • Boden, G.1    Ruiz, J.2    Urbain, J.L.3    Chen, X.4
  • 95
    • 11844277100 scopus 로고    scopus 로고
    • The basic physiology and pathophysiology of melatonin
    • Claustrat B, Brun J, Chazot G. The basic physiology and pathophysiology of melatonin. Sleep Med Rev. 2005;9(1):11-24.
    • (2005) Sleep Med Rev , vol.9 , Issue.1 , pp. 11-24
    • Claustrat, B.1    Brun, J.2    Chazot, G.3
  • 96
    • 33744899824 scopus 로고    scopus 로고
    • Diurnal rhythm in endogenous glucose production is a major contributor to fasting hyperglycaemia in type 2 diabetes. Suprachiasmatic deficit or limit cycle behaviour?
    • Radziuk J, Pye S. Diurnal rhythm in endogenous glucose production is a major contributor to fasting hyperglycaemia in type 2 diabetes. Suprachiasmatic deficit or limit cycle behaviour? Diabetologia. 2006;49(7):1619-28.
    • (2006) Diabetologia , vol.49 , Issue.7 , pp. 1619-1628
    • Radziuk, J.1    Pye, S.2
  • 97
    • 84896392653 scopus 로고    scopus 로고
    • Effects of light on the circadian rhythm of diabetic rats under restricted feeding
    • Wu T, ZhuGe F, Zhu Y, Wang N, Jiang Q, Fu H, et al. Effects of light on the circadian rhythm of diabetic rats under restricted feeding. J Physiol Biochem. 2014;70(1):61-71.
    • (2014) J Physiol Biochem , vol.70 , Issue.1 , pp. 61-71
    • Wu, T.1    Zhuge, F.2    Zhu, Y.3    Wang, N.4    Jiang, Q.5    Fu, H.6


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