Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus

Journal of Immunology

Volumn 193, Issue 8, 2014, Pages 3891-3901

  Cho, Young Nan ^a   Kee, Seung Jung ^a   Kim, Tae Jong ^a   Jin, Hye Mi ^a   Kim, Moon Ju ^a   Jung, Hyun Ju ^a   Park, Ki Jeong ^a   Lee, Sung Ji ^a   Lee, Shin Seok ^a   Kwon, Yong Soo ^a   Kee, Hae Jin ^b   Kim, Nacksung ^a   Park, Yong Wook ^a  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CALCINEURIN; CALCIUM ION; GAMMA INTERFERON; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT1; UNCLASSIFIED DRUG; ALPHA-GALACTOSYLCERAMIDE; CYTOKINE; GALACTOSYLCERAMIDE; NFATC2 PROTEIN, HUMAN; PDCD1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR NFAT;

ADULT; ANKYLOSING SPONDYLITIS; ARTICLE; BEHCET DISEASE; CD8+ T LYMPHOCYTE; CELL INTERACTION; CELL STIMULATION; CELLULAR IMMUNODEFICIENCY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DAS28; DISEASE ACTIVITY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNE DYSREGULATION; LYMPHOCYTE FUNCTION; MAJOR CLINICAL STUDY; MALE; MUCOSAL IMMUNITY; MUCOSAL INVARIANT T LYMPHOCYTE; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SLEDAI; SYNOVIAL FLUID; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; ACTIVE TRANSPORT; AUTOIMMUNE DISEASE; BIOSYNTHESIS; CALCIUM SIGNALING; CYTOLOGY; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; METABOLISM; MIDDLE AGED; NATURAL KILLER T CELL;

ACTIVE TRANSPORT, CELL NUCLEUS; ADULT; ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; CALCINEURIN; CALCIUM SIGNALING; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FEMALE; GALACTOSYLCERAMIDES; HUMANS; IMMUNITY, MUCOSAL; INTERFERON-GAMMA; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; NATURAL KILLER T-CELLS; NFATC TRANSCRIPTION FACTORS; PROGRAMMED CELL DEATH 1 RECEPTOR; SYNOVIAL FLUID; T-LYMPHOCYTE SUBSETS;

EID: 84907487373     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1302701     Document Type: Article

References (48)

1. Treiner, E., L. Duban, S. Bahram, M. Radosavljevic, V. Wanner, F. Tilloy, P. Affaticati, S. Gilfillan, and O. Lantz. 2003. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 422: 164-169.
2. Walker, L. J., Y. H. Kang, M. O. Smith, H. Tharmalingham, N. Ramamurthy, V. M. Fleming, N. Sahgal, A. Leslie, Y. Oo, A. Geremia, et al. 2012. Human MAIT and CD8α α cells develop from a pool of type-17 precommitted CD8+ T cells. Blood 119: 422-433.
3. Dusseaux, M., E. Martin, N. Serriari, I. Péguillet, V. Premel, D. Louis, M. Milder, L. Le Bourhis, C. Soudais, E. Treiner, and O. Lantz. 2011. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood 117: 1250-1259.
4. Le Bourhis, L., E. Martin, I. Péguillet, A. Guihot, N. Froux, M. Coré, E. Lévy, M. Dusseaux, V. Meyssonnier, V. Premel, et al. 2010. Antimicrobial activity of mucosal-associated invariant T cells. [Published erratum appears in 2010 Nat. Immunol. 11: 969.] Nat. Immunol. 11: 701-708.
5. Martin, E., E. Treiner, L. Duban, L. Guerri, H. Laude, C. Toly, V. Premel, A. Devys, I. C. Moura, F. Tilloy, et al. 2009. Stepwise development of MAIT cells in mouse and human. PLoS Biol. 7: e54.
6. Le Bourhis, L., L. Guerri, M. Dusseaux, E. Martin, C. Soudais, and O. Lantz. 2011. Mucosal-associated invariant T cells: unconventional development and function. Trends Immunol. 32: 212-218.
7. Kjer-Nielsen, L., O. Patel, A. J. Corbett, J. Le Nours, B. Meehan, L. Liu, M. Bhati, Z. Chen, L. Kostenko, R. Reantragoon, et al. 2012. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 491: 717-723.
8. Chua, W. J., S. M. Truscott, C. S. Eickhoff, A. Blazevic, D. F. Hoft, and T. H. Hansen. 2012. Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection. Infect. Immun. 80: 3256-3267.
9. Georgel, P., M. Radosavljevic, C. Macquin, and S. Bahram. 2011. The nonconventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice. Mol. Immunol. 48: 769-775.
10. Gold, M. C., S. Cerri, S. Smyk-Pearson, M. E. Cansler, T. M. Vogt, J. Delepine, E. Winata, G. M. Swarbrick, W. J. Chua, Y. Y. Yu, et al. 2010. Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol. 8: e1000407.
11. Lantz, O., and A. Bendelac. 1994. An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. J. Exp. Med. 180: 1097-1106.
12. Bendelac, A., O. Lantz, M. E. Quimby, J. W. Yewdell, J. R. Bennink, and R. R. Brutkiewicz. 1995. CD1 recognition by mouse NK1+ T lymphocytes. Science 268: 863-865.
13. Kawano, T., J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, et al. 1997. CD1d-restricted and TCRmediated activation of valpha14 NKT cells by glycosylceramides. Science 278: 1626-1629.
14. Spada, F. M., Y. Koezuka, and S. A. Porcelli. 1998. CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells. J. Exp. Med. 188: 1529-1534.
15. Van Kaer, L. 2005. alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles. Nat. Rev. Immunol. 5: 31-42.
16. Godfrey, D. I., and M. Kronenberg. 2004. Going both ways: immune regulation via CD1d-dependent NKT cells. J. Clin. Invest. 114: 1379-1388.
17. Cho, Y. N., S. J. Kee, S. J. Lee, S. R. Seo, T. J. Kim, S. S. Lee, M. S. Kim, W. W. Lee, D. H. Yoo, N. Kim, and Y. W. Park. 2011. Numerical and functional deficiencies of natural killer T cells in systemic lupus erythematosus: their deficiency related to disease activity. Rheumatology (Oxford) 50: 1054-1063.
18. Kojo, S., Y. Adachi, H. Keino, M. Taniguchi, and T. Sumida. 2001. Dysfunction of T cell receptor AV24AJ18+, BV11+ double-negative regulatory natural killer T cells in autoimmune diseases. Arthritis Rheum. 44: 1127-1138.
19. Lee, S. J., Y. N. Cho, T. J. Kim, S. C. Park, D. J. Park, H. M. Jin, S. S. Lee, S. J. Kee, N. Kim, D. H. Yoo, and Y. W. Park. 2012. Natural killer T cell deficiency in active adult-onset Still's Disease: correlation of deficiency of natural killer T cells with dysfunction of natural killer cells. Arthritis Rheum. 64: 2868-2877.
20. Tudhope, S. J., A. von Delwig, J. Falconer, A. Pratt, T. Woolridge, G. Wilson, J. D. Isaacs, and W. F. Ng. 2010. Profound invariant natural killer T-cell deficiency in inflammatory arthritis. Ann. Rheum. Dis. 69: 1873-1879.
21. Greenaway, H. Y., B. Ng, D. A. Price, D. C. Douek, M. P. Davenport, and V. Venturi. 2013. NKT and MAIT invariant TCRa sequences can be produced efficiently by VJ gene recombination. Immunobiology 218: 213-224.
22. Savage, A. K., M. G. Constantinides, J. Han, D. Picard, E. Martin, B. Li, O. Lantz, and A. Bendelac. 2008. The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 29: 391-403.
23. Hasni, S., A. Ippolito, and G. G. Illei. 2011. Helicobacter pylori and autoimmune diseases. Oral Dis. 17: 621-627.
24. Scher, J. U., and S. B. Abramson. 2011. The microbiome and rheumatoid arthritis. Nat. Rev. Rheumatol. 7: 569-578.
25. Chiba, A., R. Tajima, C. Tomi, Y. Miyazaki, T. Yamamura, and S. Miyake. 2012. Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis. Arthritis Rheum. 64: 153-161.
26. Miyazaki, Y., S. Miyake, A. Chiba, O. Lantz, and T. Yamamura. 2011. Mucosalassociated invariant T cells regulate Th1 response in multiple sclerosis. Int. Immunol. 23: 529-535.
27. Hochberg, M. C. 1997. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 40: 1725.
28. Aletaha, D., T. Neogi, A. J. Silman, J. Funovits, D. T. Felson, C. O. Bingham, III, N. S. Birnbaum, G. R. Burmester, V. P. Bykerk, M. D. Cohen, et al. 2010. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 62: 2569-2581.
29. van der Linden, S., H. A. Valkenburg, and A. Cats. 1984. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 27: 361-368.
30. International Study Group for Behçet's Disease. 1990. Criteria for diagnosis of Behçet's disease. Lancet 335: 1078-1080.
31. Pasquinelli, V., A. I. Rovetta, I. B. Alvarez, J. O. Jurado, R. M. Musella, D. J. Palmero, A. Malbrán, B. Samten, P. F. Barnes, and V. E. García. 2013. Phosphorylation of mitogen-activated protein kinases contributes to interferon g production in response to Mycobacterium tuberculosis. J. Infect. Dis. 207: 340-350.
32. Sada-Ovalle, I., A. Chiba, A. Gonzales, M. B. Brenner, and S. M. Behar. 2008. Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria. PLoS Pathog. 4: e1000239.
33. Teixeira, L. K., B. P. Fonseca, A. Vieira-de-Abreu, B. A. Barboza, B. K. Robbs, P. T. Bozza, and J. P. Viola. 2005. IFN-gamma production by CD8+ T cells depends on NFAT1 transcription factor and regulates Th differentiation. J. Immunol. 175: 5931-5939.
34. Leeansyah, E., A. Ganesh, M. F. Quigley, A. Sönnerborg, J. Andersson, P. W. Hunt, M. Somsouk, S. G. Deeks, J. N. Martin, M. Moll, et al. 2013. Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection. Blood 121: 1124-1135.
35. Rao, A., C. Luo, and P. G. Hogan. 1997. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15: 707-747.
36. Keir, M. E., M. J. Butte, G. J. Freeman, and A. H. Sharpe. 2008. PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26: 677-704.
37. Chang, W. S., J. Y. Kim, Y. J. Kim, Y. S. Kim, J. M. Lee, M. Azuma, H. Yagita, and C. Y. Kang. 2008. Cutting edge: Programmed death-1/programmed death ligand 1 interaction regulates the induction and maintenance of invariant NKT cell anergy. J. Immunol. 181: 6707-6710.
38. Parekh, V. V., S. Lalani, S. Kim, R. Halder, M. Azuma, H. Yagita, V. Kumar, L. Wu, and L. V. Kaer. 2009. PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J. Immunol. 182: 2816-2826.
39. Cosgrove, C., J. E. Ussher, A. Rauch, K. Gärtner, A. Kurioka, M. H. Hühn, K. Adelmann, Y. H. Kang, J. R. Fergusson, P. Simmonds, et al. 2013. Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood 121: 951-961.
40. Park, Y. W., S. J. Kee, Y. N. Cho, E. H. Lee, H. Y. Lee, E. M. Kim, M. H. Shin, J. J. Park, T. J. Kim, S. S. Lee, et al. 2009. Impaired differentiation and cytotoxicity of natural killer cells in systemic lupus erythematosus. Arthritis Rheum. 60: 1753-1763.
41. Gérart, S., S. Sibéril, E. Martin, C. Lenoir, C. Aguilar, C. Picard, O. Lantz, A. Fischer, and S. Latour. 2013. Human iNKT and MAIT cells exhibit a PLZFdependent proapoptotic propensity that is counterbalanced by XIAP. Blood 121: 614-623.
42. Chikuma, S., S. Terawaki, T. Hayashi, R. Nabeshima, T. Yoshida, S. Shibayama, T. Okazaki, and T. Honjo. 2009. PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo. J. Immunol. 182: 6682-6689.
43. Tsushima, F., S. Yao, T. Shin, A. Flies, S. Flies, H. Xu, K. Tamada, D. M. Pardoll, and L. Chen. 2007. Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood 110: 180-185.
44. Kee, S. J., Y. S. Kwon, Y. W. Park, Y. N. Cho, S. J. Lee, T. J. Kim, S. S. Lee, H. C. Jang, M. G. Shin, J. H. Shin, et al. 2012. Dysfunction of natural killer T cells in patients with active Mycobacterium tuberculosis infection. Infect. Immun. 80: 2100-2108.
45. Blackburn, S. D., H. Shin, W. N. Haining, T. Zou, C. J. Workman, A. Polley, M. R. Betts, G. J. Freeman, D. A. Vignali, and E. J. Wherry. 2009. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 10: 29-37.
46. Desmetz, C., Y. L. Lin, C. Mettling, P. Portalès, D. Noël, J. Clot, C. Jorgensen, and P. Corbeau. 2007. Cell surface CCR5 density determines the intensity of T cell migration towards rheumatoid arthritis synoviocytes. Clin. Immunol. 123: 148-154.
47. Nanki, T., T. Shimaoka, K. Hayashida, K. Taniguchi, S. Yonehara, and N. Miyasaka. 2005. Pathogenic role of the CXCL16-CXCR6 pathway in rheumatoid arthritis. Arthritis Rheum. 52: 3004-3014.
48. Ruth, J. H., S. Shahrara, C. C. Park, J. C. Morel, P. Kumar, S. Qin, and A. E. Koch. 2003. Role of macrophage inflammatory protein-3alpha and its ligand CCR6 in rheumatoid arthritis. Lab. Invest. 83: 579-588.