-
1
-
-
70349689918
-
The aging of the immune system
-
Weiskopf, D., Weinberger, B. & Grubeck-Loebenstein, B. The aging of the immune system. Transplant international: official journal of the European Society for Organ Transplantation 22, 1041-1050 (2009).
-
(2009)
Transplant International: Official Journal of the European Society for Organ Transplantation
, vol.22
, pp. 1041-1050
-
-
Weiskopf, D.1
Weinberger, B.2
Grubeck-Loebenstein, B.3
-
2
-
-
84900012738
-
A systems biology approach to the effect of aging, immunosenescence and vaccine response
-
Poland, G. A., Ovsyannikova, I. G., Kennedy, R. B., Lambert, N. D. & Kirkland, J. L. A systems biology approach to the effect of aging, immunosenescence and vaccine response. Current opinion in immunology 29, 62-68 (2014).
-
(2014)
Current Opinion in Immunology
, vol.29
, pp. 62-68
-
-
Poland, G.A.1
Ovsyannikova, I.G.2
Kennedy, R.B.3
Lambert, N.D.4
Kirkland, J.L.5
-
3
-
-
79955964506
-
Age effects on B cells and humoral immunity in humans
-
Frasca, D., Diaz, A., Romero, M., Landin, A. M. & Blomberg, B. B. Age effects on B cells and humoral immunity in humans. Ageing Res Rev 10, 330-335 (2011).
-
(2011)
Ageing Res Rev
, vol.10
, pp. 330-335
-
-
Frasca, D.1
Diaz, A.2
Romero, M.3
Landin, A.M.4
Blomberg, B.B.5
-
4
-
-
61349097791
-
B-cell responses to vaccination at the extremes of age
-
Siegrist, C. A. & Aspinall, R. B-cell responses to vaccination at the extremes of age. Nature reviews. Immunology 9, 185-194 (2009).
-
(2009)
Nature Reviews. Immunology
, vol.9
, pp. 185-194
-
-
Siegrist, C.A.1
Aspinall, R.2
-
5
-
-
84920982264
-
Variation in the human immune system is largely driven by non-heritable influences
-
Brodin, P. et al. Variation in the human immune system is largely driven by non-heritable influences. Cell 160, 37-47 (2015).
-
(2015)
Cell
, vol.160
, pp. 37-47
-
-
Brodin, P.1
-
6
-
-
84883760080
-
How to define biomarkers of human T cell aging and immunocompetence?
-
Herndler-Brandstetter, D., Ishigame, H. & Flavell, R. A. How to define biomarkers of human T cell aging and immunocompetence? Front Immunol 4, 136 (2013).
-
(2013)
Front Immunol
, vol.4
, pp. 136
-
-
Herndler-Brandstetter, D.1
Ishigame, H.2
Flavell, R.A.3
-
7
-
-
84857416171
-
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans
-
den Braber, I. et al. Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans. Immunity 36, 288-297 (2012).
-
(2012)
Immunity
, vol.36
, pp. 288-297
-
-
Den Braber, I.1
-
8
-
-
84874831901
-
Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors
-
Pekalski, M. L. et al. Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors. The Journal of Immunology 190, 2554-2566 (2013).
-
(2013)
The Journal of Immunology
, vol.190
, pp. 2554-2566
-
-
Pekalski, M.L.1
-
9
-
-
79959770648
-
Gain and loss of T cell subsets in old age-age-related reshaping of the T cell repertoire
-
Arnold, C. R., Wolf, J., Brunner, S., Herndler-Brandstetter, D. & Grubeck-Loebenstein, B. Gain and loss of T cell subsets in old age-age-related reshaping of the T cell repertoire. J Clin Immunol 31, 137-146 (2011).
-
(2011)
J Clin Immunol
, vol.31
, pp. 137-146
-
-
Arnold, C.R.1
Wolf, J.2
Brunner, S.3
Herndler-Brandstetter, D.4
Grubeck-Loebenstein, B.5
-
11
-
-
77955720671
-
Tracing thymic output in older individuals
-
Mitchell, W. A., Lang, P. O. & Aspinall, R. Tracing thymic output in older individuals. Clinical and experimental immunology 161, 497-503 (2010).
-
(2010)
Clinical and Experimental Immunology
, vol.161
, pp. 497-503
-
-
Mitchell, W.A.1
Lang, P.O.2
Aspinall, R.3
-
12
-
-
84880571140
-
Reversing T cell immunosenescence: Why, who, and how
-
Lang, P. O., Govind, S. & Aspinall, R. Reversing T cell immunosenescence: why, who, and how. Age (Dordr) 35, 609-620 (2013).
-
(2013)
Age (Dordr)
, vol.35
, pp. 609-620
-
-
Lang, P.O.1
Govind, S.2
Aspinall, R.3
-
13
-
-
67649407892
-
CD28(-) T cells: Their role in the age-associated decline of immune function
-
Weng, N. P., Akbar, A. N. & Goronzy, J. CD28(-) T cells: their role in the age-associated decline of immune function. Trends Immunol 30, 306-312 (2009).
-
(2009)
Trends Immunol
, vol.30
, pp. 306-312
-
-
Weng, N.P.1
Akbar, A.N.2
Goronzy, J.3
-
15
-
-
20444497416
-
The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age
-
Gregg, R. et al. The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age. Clinical and experimental immunology 140, 540-546 (2005).
-
(2005)
Clinical and Experimental Immunology
, vol.140
, pp. 540-546
-
-
Gregg, R.1
-
16
-
-
0038579780
-
Autoimmunity and geriatrics: Clinical significance of autoimmune manifestations in the elderly
-
Ramos-Casals, M., Garcia-Carrasco, M., Brito, M., Lopez-Soto, A. & Font, J. Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly. Lupus 12, 341-355 (2003).
-
(2003)
Lupus
, vol.12
, pp. 341-355
-
-
Ramos-Casals, M.1
Garcia-Carrasco, M.2
Brito, M.3
Lopez-Soto, A.4
Font, J.5
-
17
-
-
84881526076
-
Slower immune system aging in women versus men in the Japanese population
-
Hirokawa, K. et al. Slower immune system aging in women versus men in the Japanese population. Immun Ageing 10, 19 (2013).
-
(2013)
Immun Ageing
, vol.10
, pp. 19
-
-
Hirokawa, K.1
-
18
-
-
84940893611
-
Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans
-
Geest, K. S. et al. Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans. Aging cell (2015).
-
(2015)
Aging Cell
-
-
Geest, K.S.1
-
19
-
-
50649111879
-
The immune risk profile is associated with age and gender: Findings from three Swedish population studies of individuals 20-100 years of age
-
Wikby, A., Mansson, I. A., Johansson, B., Strindhall, J. & Nilsson, S. E. The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age. Biogerontology 9, 299-308 (2008).
-
(2008)
Biogerontology
, vol.9
, pp. 299-308
-
-
Wikby, A.1
Mansson, I.A.2
Johansson, B.3
Strindhall, J.4
Nilsson, S.E.5
-
20
-
-
84880571275
-
The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: The Swedish HEXA immune study
-
Strindhall, J. et al. The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study. Age (Dordr) 35, 985-991 (2013).
-
(2013)
Age (Dordr)
, vol.35
, pp. 985-991
-
-
Strindhall, J.1
-
21
-
-
77953191669
-
Circulating human B and plasma cells. Age-associated changes in counts and detailed characterization of circulating normal CD138-and CD138+ plasma cells
-
Caraux, A. et al. Circulating human B and plasma cells. Age-associated changes in counts and detailed characterization of circulating normal CD138-and CD138+ plasma cells. Haematologica 95, 1016-1020 (2010).
-
(2010)
Haematologica
, vol.95
, pp. 1016-1020
-
-
Caraux, A.1
-
23
-
-
84998992276
-
Cytomegalovirus latency and reactivation: Recent insights into an age old problem
-
Dupont, L. & Reeves, M. B. Cytomegalovirus latency and reactivation: recent insights into an age old problem. Reviews in medical virology (2015).
-
(2015)
Reviews in Medical Virology
-
-
Dupont, L.1
Reeves, M.B.2
-
24
-
-
81255188983
-
Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans
-
Derhovanessian, E. et al. Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans. Journal of General Virology 92, 2746-2756 (2011).
-
(2011)
Journal of General Virology
, vol.92
, pp. 2746-2756
-
-
Derhovanessian, E.1
-
25
-
-
84865302673
-
The impact of CMV infection on survival in older humans
-
Pawelec, G., McElhaney, J. E., Aiello, A. E. & Derhovanessian, E. The impact of CMV infection on survival in older humans. Curr Opin Immunol 24, 507-511 (2012).
-
(2012)
Curr Opin Immunol
, vol.24
, pp. 507-511
-
-
Pawelec, G.1
McElhaney, J.E.2
Aiello, A.E.3
Derhovanessian, E.4
-
26
-
-
84896501298
-
Aging and cytomegalovirus infection differentially and jointly affect distinct circulating t cell subsets in humans
-
Wertheimer, A. M. et al. Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans. The Journal of Immunology 192, 2143-2155 (2014).
-
(2014)
The Journal of Immunology
, vol.192
, pp. 2143-2155
-
-
Wertheimer, A.M.1
-
27
-
-
84959878671
-
Cytomegalovirus-and Epstein-Barr virus-induced t-cell expansions in young children do not impair naive t-cell populations or vaccination responses: The generation R study
-
van den Heuvel, D. et al. Cytomegalovirus-and Epstein-Barr Virus-Induced T-Cell Expansions in Young Children Do Not Impair Naive T-cell Populations or Vaccination Responses: The Generation R Study. Journal of Infectious Diseases 213, 233-242 (2016).
-
(2016)
Journal of Infectious Diseases
, vol.213
, pp. 233-242
-
-
Van Den Heuvel, D.1
-
28
-
-
84892778834
-
Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires
-
Wang, C. et al. Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires. The Journal of Immunology 192, 603-611 (2014).
-
(2014)
The Journal of Immunology
, vol.192
, pp. 603-611
-
-
Wang, C.1
-
29
-
-
84940592733
-
Impact of age, sex and CMV-infection on peripheral T cell phenotypes: Results from the Berlin BASE-II Study
-
Di Benedetto, S. et al. Impact of age, sex and CMV-infection on peripheral T cell phenotypes: results from the Berlin BASE-II Study. Biogerontology 1-13 (2015).
-
(2015)
Biogerontology
, pp. 1-13
-
-
Di Benedetto, S.1
-
30
-
-
84892562675
-
Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination
-
Furman, D. et al. Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination. Proceedings of the National Academy of Sciences 111, 869-874 (2014).
-
(2014)
Proceedings of the National Academy of Sciences
, vol.111
, pp. 869-874
-
-
Furman, D.1
-
31
-
-
84858450790
-
The role of gender and organ specific autoimmunity
-
Nussinovitch, U. & Shoenfeld, Y. The role of gender and organ specific autoimmunity. Autoimmunity reviews 11, A377-A385 (2012).
-
(2012)
Autoimmunity Reviews
, vol.11
, pp. A377-A385
-
-
Nussinovitch, U.1
Shoenfeld, Y.2
-
32
-
-
84927911989
-
How sex and age affect immune responses, susceptibility to infections, and response to vaccination
-
Giefing-Kroll, C., Berger, P., Lepperdinger, G. & Grubeck-Loebenstein, B. How sex and age affect immune responses, susceptibility to infections, and response to vaccination. Aging cell 14, 309-321 (2015).
-
(2015)
Aging Cell
, vol.14
, pp. 309-321
-
-
Giefing-Kroll, C.1
Berger, P.2
Lepperdinger, G.3
Grubeck-Loebenstein, B.4
-
33
-
-
84930911630
-
Sex, the aging immune system, and chronic disease
-
Bupp, M. R. G. Sex, the aging immune system, and chronic disease. Cellular immunology 294, 102-110 (2015).
-
(2015)
Cellular Immunology
, vol.294
, pp. 102-110
-
-
Bupp, M.R.G.1
-
34
-
-
84856854316
-
Immunosenescence and herd immunity: With an ever-increasing aging population do we need to rethink vaccine schedules?
-
Lang, P. O. & Aspinall, R. Immunosenescence and herd immunity: with an ever-increasing aging population do we need to rethink vaccine schedules? Expert Review of Vaccines 11, 167-176 (2012).
-
(2012)
Expert Review of Vaccines
, vol.11
, pp. 167-176
-
-
Lang, P.O.1
Aspinall, R.2
-
35
-
-
77950412178
-
Workshop on immunizations in older adults: Identifying future research agendas
-
High, K. P. et al. Workshop on immunizations in older adults: identifying future research agendas. J Am Geriatr Soc 58, 765-776 (2010).
-
(2010)
J Am Geriatr Soc
, vol.58
, pp. 765-776
-
-
High, K.P.1
-
36
-
-
84958593673
-
Low thymic activity and dendritic cell numbers are associated with the immune response to primary viral infection in elderly humans
-
Schulz, A. R. et al. Low Thymic Activity and Dendritic Cell Numbers Are Associated with the Immune Response to Primary Viral Infection in Elderly Humans. The Journal of Immunology 195, 4699-4711 (2015).
-
(2015)
The Journal of Immunology
, vol.195
, pp. 4699-4711
-
-
Schulz, A.R.1
-
37
-
-
84890832543
-
From "truly naive" to "exhausted senescent" T cells: When markers predict functionality
-
Larbi, A. & Fulop, T. From "truly naive" to "exhausted senescent" T cells: when markers predict functionality. Cytometry Part A 85, 25-35 (2014).
-
(2014)
Cytometry Part A
, vol.85
, pp. 25-35
-
-
Larbi, A.1
Fulop, T.2
-
38
-
-
84907223820
-
Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly
-
Derhovanessian, E. et al. Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly. The Journal of Immunology 193, 3624-3631 (2014).
-
(2014)
The Journal of Immunology
, vol.193
, pp. 3624-3631
-
-
Derhovanessian, E.1
-
39
-
-
0002437146
-
Sex differences in susceptibility to infections
-
Washburn, T. C., Medearis, D. N. & Childs, B. Sex differences in susceptibility to infections. Pediatrics 35, 57-64 (1965).
-
(1965)
Pediatrics
, vol.35
, pp. 57-64
-
-
Washburn, T.C.1
Medearis, D.N.2
Childs, B.3
-
40
-
-
84969759563
-
Follicular helper T cells
-
Vinuesa, C. G., Linterman, M., Yu, D. & MacLennan, I. C. Follicular Helper T Cells. Annual Review of Immunology 34 (2016).
-
(2016)
Annual Review of Immunology
, vol.34
-
-
Vinuesa, C.G.1
Linterman, M.2
Yu, D.3
MacLennan, I.C.4
-
41
-
-
84891760313
-
How T follicular helper cells and the germinal centre response change with age
-
Linterman, M. A. How T follicular helper cells and the germinal centre response change with age. Immunology and cell biology 92, 72-79 (2014).
-
(2014)
Immunology and Cell Biology
, vol.92
, pp. 72-79
-
-
Linterman, M.A.1
-
42
-
-
84907200998
-
Circulating CXCR5+ PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults
-
Herati, R. S. et al. Circulating CXCR5+ PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults. The Journal of Immunology 193, 3528-3537 (2014).
-
(2014)
The Journal of Immunology
, vol.193
, pp. 3528-3537
-
-
Herati, R.S.1
-
43
-
-
84909578684
-
Aging disturbs the balance between effector and regulatory CD4+ T cells
-
van der Geest, K. S. et al. Aging disturbs the balance between effector and regulatory CD4+ T cells. Experimental gerontology 60, 190-196 (2014).
-
(2014)
Experimental Gerontology
, vol.60
, pp. 190-196
-
-
Van Der Geest, K.S.1
-
44
-
-
84885427059
-
Varicella zoster virus infection occurs at A relatively young age in the Netherlands
-
van Lier, A. et al. Varicella zoster virus infection occurs at A relatively young age in the Netherlands. Vaccine 31, 5127-5133 (2013).
-
(2013)
Vaccine
, vol.31
, pp. 5127-5133
-
-
Van Lier, A.1
-
45
-
-
84973363209
-
Determinants of ethnic differences in cytomegalovirus, Epstein-Barr virus, and herpes simplex virus type 1 seroprevalence in childhood
-
Jansen, M. A. et al. Determinants of Ethnic Differences in Cytomegalovirus, Epstein-Barr Virus, and Herpes Simplex Virus Type 1 Seroprevalence in Childhood. The Journal of pediatrics (2015).
-
(2015)
The Journal of Pediatrics
-
-
Jansen, M.A.1
-
46
-
-
84916198770
-
Effects of cigarette smoking on circulating leukocytes and plasma cytokines in monozygotic twins
-
Andreoli, C. et al. Effects of cigarette smoking on circulating leukocytes and plasma cytokines in monozygotic twins. Clinical Chemistry and Laboratory Medicine (CCLM) 53, 57-64 (2015).
-
(2015)
Clinical Chemistry and Laboratory Medicine (CCLM)
, vol.53
, pp. 57-64
-
-
Andreoli, C.1
-
47
-
-
84914172161
-
Gender differences and age-specific associations between body mass index and other cardiovascular risk factors in CMV infected and uninfected people
-
Terrazzini, N., Bajwa, M., Thomas, D., Smith, H. & Kern, F. Gender differences and age-specific associations between body mass index and other cardiovascular risk factors in CMV infected and uninfected people. Immunology letters 162, 316-322 (2014).
-
(2014)
Immunology Letters
, vol.162
, pp. 316-322
-
-
Terrazzini, N.1
Bajwa, M.2
Thomas, D.3
Smith, H.4
Kern, F.5
-
48
-
-
84860914897
-
Exercise and the aging immune system
-
Simpson, R. J. et al. Exercise and the aging immune system. Ageing research reviews 11, 404-420 (2012).
-
(2012)
Ageing Research Reviews
, vol.11
, pp. 404-420
-
-
Simpson, R.J.1
-
49
-
-
84973391174
-
Markers of T-cell senescence and physical frailty: Insights from Singapore Longitudinal Ageing Studies
-
Ng, T. P. et al. Markers of T-cell senescence and physical frailty: insights from Singapore Longitudinal Ageing Studies. npj Aging and Mechanisms of Disease 1 (2015).
-
(2015)
Npj Aging and Mechanisms of Disease
, vol.1
-
-
Ng, T.P.1
-
50
-
-
84953431586
-
Reference ranges of 17-hydroxyprogesterone, DHEA, DHEAS, androstenedione, total and free testosterone determined by TurboFlow-LC-MS/MS and associations to health markers in 304 men
-
Damgaard-Olesen, A. et al. Reference ranges of 17-hydroxyprogesterone, DHEA, DHEAS, androstenedione, total and free testosterone determined by TurboFlow-LC-MS/MS and associations to health markers in 304 men. Clinica Chimica Acta 454, 82-88 (2016).
-
(2016)
Clinica Chimica Acta
, vol.454
, pp. 82-88
-
-
Damgaard-Olesen, A.1
-
51
-
-
0001090139
-
The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-β 1) levels in normal healthy blood donors
-
Young, D., Skibinski, G., Mason, J. & James, K. The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-β 1) levels in normal healthy blood donors. Clinical and experimental immunology 117, 476 (1999).
-
(1999)
Clinical and Experimental Immunology
, vol.117
, pp. 476
-
-
Young, D.1
Skibinski, G.2
Mason, J.3
James, K.4
-
53
-
-
80155149402
-
Dehydroepiandrosterone (DHEA) - A precursor steroid or an active hormone in human physiology (CME)
-
Traish, A. M., Kang, H. P., Saad, F. & Guay, A. T. Dehydroepiandrosterone (DHEA) - a precursor steroid or an active hormone in human physiology (CME). The journal of sexual medicine 8, 2960-2982 (2011).
-
(2011)
The Journal of Sexual Medicine
, vol.8
, pp. 2960-2982
-
-
Traish, A.M.1
Kang, H.P.2
Saad, F.3
Guay, A.T.4
-
54
-
-
84975118727
-
Persistent subclinical immune defects in HIV-1-infected children treated with antiretroviral therapy
-
van Den Heuvel, D. et al. Persistent subclinical immune defects in HIV-1-infected children treated with antiretroviral therapy. AIDS 29, 1745-1756 (2015).
-
(2015)
AIDS
, vol.29
, pp. 1745-1756
-
-
Van Den Heuvel, D.1
-
55
-
-
66949171924
-
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
-
Miyara, M. et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30, 899-911 (2009).
-
(2009)
Immunity
, vol.30
, pp. 899-911
-
-
Miyara, M.1
-
56
-
-
80052171651
-
Human memory B cells originate from three distinct germinal center-dependent and-independent maturation pathways
-
Berkowska, M. A. et al. Human memory B cells originate from three distinct germinal center-dependent and-independent maturation pathways. Blood 118, 2150-2158 (2011).
-
(2011)
Blood
, vol.118
, pp. 2150-2158
-
-
Berkowska, M.A.1
-
57
-
-
0033554726
-
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
-
Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712 (1999).
-
(1999)
Nature
, vol.401
, pp. 708-712
-
-
Sallusto, F.1
Lenig, D.2
Forster, R.3
Lipp, M.4
Lanzavecchia, A.5
-
58
-
-
55949116720
-
Phenotype and function of human T lymphocyte subsets: Consensus and issues
-
Appay, V., Van Lier, R. A., Sallusto, F. & Roederer, M. Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry Part A 73, 975-983 (2008).
-
(2008)
Cytometry Part A
, vol.73
, pp. 975-983
-
-
Appay, V.1
Van Lier, R.A.2
Sallusto, F.3
Roederer, M.4
-
59
-
-
84865855905
-
EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols
-
Kalina, T. et al. EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols. Leukemia 26, 1986-2010 (2012).
-
(2012)
Leukemia
, vol.26
, pp. 1986-2010
-
-
Kalina, T.1
|