Markers of T-cell senescence and physical frailty: Insights from Singapore longitudinal ageing studies

npj Aging and Mechanisms of Disease

Volumn 1, Issue 1, 2015, Pages

  Ng, Tze Pin ^a   Camous, Xavier ^b   Nyunt, Ma Shwe Zin ^a   Vasudev, Anusha ^b   Tan, Crystal Tze Ying ^b   Feng, Liang ^a   Fulop, Tamas ^c   Yap, Keng Bee ^d   Larbi, Anis ^b  

^a NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

^d ALEXANDRA HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84973391174     PISSN: None     EISSN: 20563973     Source Type: Journal    
DOI: 10.1038/npjamd.2015.5     Document Type: Article

References (36)

1. Fulop T, Larbi A, Witkowski JM, McElhaney J, Loeb M, Mitnitski A et al. Aging, frailty and age-related diseases. Biogerontology 2010; 11: 547–563.
2. Abellan van Kan G, Rolland Y, Bergman H, Morley JE, Kritchevsky SB, Vellas B. The I.A.N.A Task Force on frailty assessment of older people in clinical practice. J Nutr Health Aging 2008; 12: 29–37.
3. Walston J, McBurnie MA, Newman A, Tracy RP, Kop WJ, Hirsch CH et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from The Cardiovascular Health Study. Arch Intern Med 2002; 162: 2333–2341.
4. Leng SX, Xue QL, Tian J, Walston JD, Fried LP. Inflammation and frailty in older women. J Am Geriatr Soc 2007; 55: 864–871.
5. Miller RA. The aging immune system: primer and prospectus. Science 1996; 273: 70–74.
6. Webster RG. Immunity to influenza in the elderly. Vaccine 2000; 18: 1686–1689.
7. Roberts-Thomson IC, Whittingham S, Youngchaiyud U, Mackay IR. Ageing, immune response, and mortality. Lancet 1974; 2: 368–370.
8. Boucher N, Dufeu-Duchesne T, Vicaut E, Farge D, Effros RB, Schächter F. CD28 expression in T cell aging and human longevity. Exp Gerontol 1998; 33: 267–282.
9. Pawelec G, Adibzadeh M, Solana R, Beckman I. The T cell in the ageing individual. Mech Ageing Dev 1997; 93: 35–45.
10. Hendriks J, Gravestein LA, Tesselaar K, van Lier RA, Schumacher TN, Borst J. CD27 is required for generation and long-term maintenance of T cell immunity. Nat Immunol 2000; 1: 433–440.
11. Hikono H, Kohlmeier JE, Takamura S, Wittmer ST, Roberts AD, Woodland DL. Activation phenotype, rather than central-or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells. J Exp Med 2007; 204: 1625–1636.
12. Duttagupta PA, Boesteanu AC, Katsikis PD. Costimulation signals for memory CD8 + T cells during viral infections. Crit Rev Immunol 2009; 29: 469–486.
13. Olsson J, Wikby A, Johansson B, Löfgren S, Nilsson BO, Ferguson FG. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev 2000; 121: 187–201.
14. Wikby A, Ferguson F, Forsey R, Thompson J, Strindhall J, Löfgren S et al. An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. J Gerontol A Biol Sci Med Sci 2005; 60: 556–565.
15. Wikby A, Maxson P, Olsson J, Johansson B, Ferguson FG. Changes in CD8 and CD4 lymphocyte subsets T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech Ageing and Dev 1998; 102: 187–198.
16. Reker-Hadrup S, Strindhall J, Kollgaard T, Seremet T, Johansson B, Pawelec G et al. Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and increased number of dysfunctional cytomegalovirus-specific T cells in the elderly. J Immunol 2006; 176: 2645–2653.
17. Larbi A, Franceschi C, Mazzatti D, Solana R, Wikby A, Pawelec G. Aging of the immune system as a prognostic factor for human longevity. Physiology (Bethesda) 2008; 23: 64–74.
18. Derhovanessian E, Larbi A, Pawelec G. Biomarkers of human immunosenescence: impact of Cytomegalovirus infection. Curr Opin Immunol. 2009; 21: 440–445.
19. Wang EC, Moss PA, Frodsham P, Lehner PJ, Bell JI, Borysiewicz LK. CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus. J Immunol 1995; 155: 5046–5056.
20. Looney RJ, Falsey A, Campbell D, Torres A, Kolassa J, Brower C et al. Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin Immunol 1999; 90: 213–219.
21. Goronzy JJ, Weyand CM. Understanding immunosenescence to improve responses to vaccines. Nat Immunol 2013; 14: 428–436.
22. De Fanis U, Wang GC, Fedarko NS, Walston JD, Casolaro V, Leng SX. T-Lymphocytes Expressing CC Chemokine Receptor-5 Are Increased in Frail Older Adults. J Am Geriatr Soc 2008; 56: 904–908.
23. Semba RD, Margolick JB, Leng S, Walston J, Ricks MO, Fried LP. T cell subsets and mortality in older community-dwelling women. Exp Geron 2005; 40: 81–87.
24. Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C et al. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study. Mech Ageing Dev 2012; 133: 456–466.
25. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al. Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56: M146–M156.
26. Niti M, Yap KB, Kua EH, Tan CH, Ng TP. Physical, social and productive leisure activities, cognitive decline and interaction with APOE-epsilon4 genotype in Chinese older adults. Int Psychogeriatr. 2008; 20: 1–15.
27. Ng TP, Feng L, Nyunt MSZ, Larbi A, Yap KB. Frailty in Older Persons: Multisystem Risk Factors and the Frailty Risk Index (FRI). J Am Med Dir Assoc 2014; 15: 635–642.
28. Kyu SY, Kobie J, Yang H, Zand MS, Topham DJ, Quataert SA et al. Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells. J Immunol Methods 2009; 340: 42–47.
29. Prlic M, Sacks JA, Bevan MJ. Dissociating markers of senescence and protective ability in memory T cells. PLoS One 2012; 7: e32576.
30. Hubbard RE, Woodhouse KW. Frailty, inflammation and the elderly. Biogerontology 2010; 11: 635–641.
31. Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 2010; 5: 99–118.
32. Bryl E, Vallejo AN, Weyand CM, Goronzy JJ. Down-regulation of CD28 expression by TNF-alpha. J Immunol 2001; 167: 3231–3238.
33. Panossian LA, Porter VR, Valenzuela HF, Zhu X, Reback E, Masterman D et al. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging 2003; 24: 77–84.
34. Zalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD, Blackburn EH et al. Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources. Proc Natl Acad Sci USA 2014; 111: 4519–4524.
35. Saum KU, Dieffenbach AK, Müezzinler A, Müller H, Holleczek B, Stegmaier C et al. Frailty and telomere length: Cross-sectional analysis in 3537 older adults from the ESTHER cohort. Exp Gerontol 2014; 58: 250–255.
36. Lages CS, Lewkowich I, Sproles A, Wills-Karp M, Chougnet C. Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway. Aging Cell 2010; 9: 785–798.