메뉴 건너뛰기




Volumn 6, Issue 6, 2016, Pages

The diathesis-epilepsy model: How past events impact the development of epilepsy and comorbidities

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMORBIDITY; CONCEPTUAL FRAMEWORK; DIATHESIS EPILEPSY MODEL; DISEASE COURSE; EPIGENETICS; EPILEPSY; GENETIC BACKGROUND; HUMAN; MODEL; NONHUMAN; STRESS; ANIMAL; BIOLOGICAL MODEL; COGNITIVE DEFECT; COMPLICATION; DEPRESSION; DISEASE PREDISPOSITION; GENETIC EPIGENESIS; PSYCHOLOGY; RISK FACTOR;

EID: 84973163741     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a022418     Document Type: Article
Times cited : (11)

References (74)
  • 3
    • 84927622806 scopus 로고    scopus 로고
    • Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models
    • Aiba I N J. L. 2015. Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models. Sci Transl Med 7: 282ra46.
    • (2015) Sci Transl Med , vol.7
    • Aiba, I.1
  • 4
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    • Amir RE, Van dVI, Wan M, Tran CQ, Francke U, Zoghbi HY. 1999. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 23: 185-188.
    • (1999) Nat Genet , vol.23 , pp. 185-188
    • Amir, R.E.1    Van, D.2    Wan, M.3    Tran, C.Q.4    Francke, U.5    Zoghbi, H.Y.6
  • 5
    • 84925844053 scopus 로고    scopus 로고
    • Time for food: The intimate interplay between nutrition, metabolism, and the circadian clock
    • Asher G, Sassone-Corsi P. 2015. Time for food: The intimate interplay between nutrition, metabolism, and the circadian clock. Cell 161: 84-92.
    • (2015) Cell , vol.161 , pp. 84-92
    • Asher, G.1    Sassone-Corsi, P.2
  • 6
    • 84929949604 scopus 로고    scopus 로고
    • Epigenetic and transgenerational reprogramming of brain development
    • Bale TL. 2015. Epigenetic and transgenerational reprogramming of brain development. Nat Rev Neurosci 16: 332-344.
    • (2015) Nat Rev Neurosci , vol.16 , pp. 332-344
    • Bale, T.L.1
  • 7
    • 84888436989 scopus 로고    scopus 로고
    • Pilocarpineinduced epilepsy in mice alters seizure thresholds and the efficacy of antiepileptic drugs in the 6-Hertz psychomotor seizure model
    • Bankstahl M, Bankstahl JP, Loscher W. 2013. Pilocarpineinduced epilepsy in mice alters seizure thresholds and the efficacy of antiepileptic drugs in the 6-Hertz psychomotor seizure model. Epilepsy Res 107: 205-216.
    • (2013) Epilepsy Res , vol.107 , pp. 205-216
    • Bankstahl, M.1    Bankstahl, J.P.2    Loscher, W.3
  • 8
    • 0037135190 scopus 로고    scopus 로고
    • Transcriptional profiling in human epilepsy: Expression array and single cell realtime qRT-PCR analysis reveal distinct cellular gene regulation
    • Becker AJ, Chen J, Paus S, Normann S, Beck H, Elger CE, Wiestler OD, Blumcke I. 2002. Transcriptional profiling in human epilepsy: Expression array and single cell realtime qRT-PCR analysis reveal distinct cellular gene regulation. NeuroReport 13: 1327-1333.
    • (2002) Neuroreport , vol.13 , pp. 1327-1333
    • Becker, A.J.1    Chen, J.2    Paus, S.3    Normann, S.4    Beck, H.5    Elger, C.E.6    Wiestler, O.D.7    Blumcke, I.8
  • 10
    • 79952575607 scopus 로고    scopus 로고
    • The neurobiology of cognitive disorders in temporal lobe epilepsy
    • Bell B, Lin JJ, Seidenberg M, Hermann B. 2011. The neurobiology of cognitive disorders in temporal lobe epilepsy. Nat Rev Neurol 7: 154-164.
    • (2011) Nat Rev Neurol , vol.7 , pp. 154-164
    • Bell, B.1    Lin, J.J.2    Seidenberg, M.3    Hermann, B.4
  • 11
    • 79951930596 scopus 로고    scopus 로고
    • REST: Transcriptional and epigenetic regulator
    • Bithell A. 2011. REST: Transcriptional and epigenetic regulator. Epigenomics 3: 47-58.
    • (2011) Epigenomics , vol.3 , pp. 47-58
    • Bithell, A.1
  • 13
    • 84858419592 scopus 로고    scopus 로고
    • Development of post-traumatic epilepsy after controlled cortical impact and lateral fluid-percussion-induced brain injury in the mouse
    • Bolkvadze T, Pitkanen A. 2012. Development of post-traumatic epilepsy after controlled cortical impact and lateral fluid-percussion-induced brain injury in the mouse. J Neurotrauma 29: 789-812.
    • (2012) J Neurotrauma , vol.29 , pp. 789-812
    • Bolkvadze, T.1    Pitkanen, A.2
  • 14
  • 16
    • 84949563858 scopus 로고    scopus 로고
    • Toward understanding how early-life stress reprograms cognitive and emotional brain networks
    • Chen Y, Baram TZ. 2015. Toward understanding how early-life stress reprograms cognitive and emotional brain networks. Neuropsychopharmacology doi: 10.1038/npp.2015.181.
    • (2015) Neuropsychopharmacology
    • Chen, Y.1    Baram, T.Z.2
  • 20
    • 84920828902 scopus 로고    scopus 로고
    • Seizures, refractory status epilepticus, and depolarization block as endogenous brain activities
    • El Houssaini K, Ivanov AI, Bernard C, Jirsa VK. 2015. Seizures, refractory status epilepticus, and depolarization block as endogenous brain activities. Phys Rev E 91: 010701.
    • (2015) Phys Rev E , vol.91
    • El Houssaini, K.1    Ivanov, A.I.2    Bernard, C.3    Jirsa, V.K.4
  • 24
  • 25
    • 84876665067 scopus 로고    scopus 로고
    • Mechanisms of epileptogenesis: Aconvergence on neural circuit dysfunction
    • Goldberg EM, Coulter DA. 2013. Mechanisms of epileptogenesis: Aconvergence on neural circuit dysfunction. Nat Rev Neurosci 14: 337-349.
    • (2013) Nat Rev Neurosci , vol.14 , pp. 337-349
    • Goldberg, E.M.1    Coulter, D.A.2
  • 26
    • 33751099302 scopus 로고    scopus 로고
    • Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy
    • Gorter JA, van Vliet EA, Aronica E, Breit T, Rauwerda H, Lopes da Silva FH, Wadman WJ. 2006. Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy. J Neurosci 26: 11083-11110.
    • (2006) J Neurosci , vol.26 , pp. 11083-11110
    • Gorter, J.A.1    van Vliet, E.A.2    Aronica, E.3    Breit, T.4    Rauwerda, H.5    Lopes Da Silva, F.H.6    Wadman, W.J.7
  • 27
    • 84872601036 scopus 로고    scopus 로고
    • Histone acetylation: Molecular mnemonics on the chromatin
    • Graff J, Tsai LH. 2013. Histone acetylation: Molecular mnemonics on the chromatin. Nat Rev Neurosci 14: 97-111.
    • (2013) Nat Rev Neurosci , vol.14 , pp. 97-111
    • Graff, J.1    Tsai, L.H.2
  • 28
    • 84885048035 scopus 로고    scopus 로고
    • Comprehensive mapping of regional expression of the clock protein PERIOD2 in rat forebrain across the 24-h day
    • Harbour VL, Weigl Y, Robinson B, Amir S. 2013. Comprehensive mapping of regional expression of the clock protein PERIOD2 in rat forebrain across the 24-h day. PLoS ONE 8: e76391.
    • (2013) Plos ONE , vol.8
    • Harbour, V.L.1    Weigl, Y.2    Robinson, B.3    Amir, S.4
  • 29
    • 84904878798 scopus 로고    scopus 로고
    • Phase differences in expression of circadian clock genes in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleus in the rat
    • Harbour VL, Weigl Y, Robinson B, Amir S. 2014. Phase differences in expression of circadian clock genes in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleus in the rat. PLoS ONE 9: e103309.
    • (2014) Plos ONE , vol.9
    • Harbour, V.L.1    Weigl, Y.2    Robinson, B.3    Amir, S.4
  • 30
    • 0034040924 scopus 로고    scopus 로고
    • Psychiatric comorbidity in chronic epilepsy: Identification, consequences, and treatment of major depression
    • Hermann BP, Seidenberg M, Bell B. 2000. Psychiatric comorbidity in chronic epilepsy: Identification, consequences, and treatment of major depression. Epilepsia 41: S31-S41.
    • (2000) Epilepsia , vol.41 , pp. S31-S41
    • Hermann, B.P.1    Seidenberg, M.2    Bell, B.3
  • 32
    • 80051546513 scopus 로고    scopus 로고
    • Depression in epilepsy: A critical review from a clinical perspective
    • Hoppe C, Elger CE. 2011. Depression in epilepsy: A critical review from a clinical perspective. Nat Rev Neurol 7: 462-472.
    • (2011) Nat Rev Neurol , vol.7 , pp. 462-472
    • Hoppe, C.1    Elger, C.E.2
  • 34
    • 84862491817 scopus 로고    scopus 로고
    • Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats
    • Inostroza M, Cid E, Menendez de la Prida L, Sandi C. 2012. Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats. PLoS ONE 7: e38959.
    • (2012) Plos ONE , vol.7
    • Inostroza, M.1    Cid, E.2    Menendez de la Prida, L.3    Sandi, C.4
  • 35
    • 84887065463 scopus 로고    scopus 로고
    • Specific impairment of “what-where-when” episodic-like memory in experimental models of temporal lobe epilepsy
    • Inostroza M, Brotons-Mas JR, Laurent F, Cid E, de la Prida LM. 2013. Specific impairment of “what-where-when” episodic-like memory in experimental models of temporal lobe epilepsy. J Neurosci 33: 17749-17762.
    • (2013) J Neurosci , vol.33 , pp. 17749-17762
    • Inostroza, M.1    Brotons-Mas, J.R.2    Laurent, F.3    Cid, E.4    de La Prida, L.M.5
  • 37
    • 84862208827 scopus 로고    scopus 로고
    • Crosstalk among epigenetic pathways regulates neurogenesis
    • Jobe EM, McQuate AL, Zhao X. 2012. Crosstalk among epigenetic pathways regulates neurogenesis. Front Neurosci 6: 59.
    • (2012) Front Neurosci , vol.6 , pp. 59
    • Jobe, E.M.1    McQuate, A.L.2    Zhao, X.3
  • 38
    • 34250159524 scopus 로고    scopus 로고
    • Genome-wide mapping of in vivo protein-DNA interactions
    • Johnson DS, Mortazavi A, Myers RM, Wold B. 2007. Genome-wide mapping of in vivo protein-DNA interactions. Science 316: 1497-1502.
    • (2007) Science , vol.316 , pp. 1497-1502
    • Johnson, D.S.1    Mortazavi, A.2    Myers, R.M.3    Wold, B.4
  • 39
    • 36348947267 scopus 로고    scopus 로고
    • A controlled prospective investigation of psychiatric comorbidity in temporal lobe epilepsy
    • Jones JE, Bell B, Fine J, Rutecki P, Seidenberg M, Hermann B. 2007. A controlled prospective investigation of psychiatric comorbidity in temporal lobe epilepsy. Epilepsia 48: 2357-2360.
    • (2007) Epilepsia , vol.48 , pp. 2357-2360
    • Jones, J.E.1    Bell, B.2    Fine, J.3    Rutecki, P.4    Seidenberg, M.5    Hermann, B.6
  • 42
    • 84893851651 scopus 로고    scopus 로고
    • Cognitive and behavioral co-morbidities of epilepsy
    • (ed. Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV). National Center for Biotechnology Information, Bethesda, MD
    • Kleen JK, Scott RC, Lenck-Santini PP, Holmes GL. 2012. Cognitive and behavioral co-morbidities of epilepsy. In Jasper’s basic mechanisms of the epilepsies (ed. Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV). National Center for Biotechnology Information, Bethesda, MD.
    • (2012) Jasper’s Basic Mechanisms of the Epilepsies
    • Kleen, J.K.1    Scott, R.C.2    Lenck-Santini, P.P.3    Holmes, G.L.4
  • 43
    • 84931041069 scopus 로고    scopus 로고
    • Epigenetics of stress-related psychiatric disorders and gene X environment interactions
    • Klengel T, Binder EB. 2015. Epigenetics of stress-related psychiatric disorders and gene X environment interactions. Neuron 86: 1343-1357.
    • (2015) Neuron , vol.86 , pp. 1343-1357
    • Klengel, T.1    Binder, E.B.2
  • 44
    • 84924987118 scopus 로고    scopus 로고
    • Epigenetic mechanisms in epilepsy
    • Kobow K, Blumcke I. 2014. Epigenetic mechanisms in epilepsy. Prog Brain Res 213: 279-316.
    • (2014) Prog Brain Res , vol.213 , pp. 279-316
    • Kobow, K.1    Blumcke, I.2
  • 45
    • 65349147637 scopus 로고    scopus 로고
    • Stressors at the onset of adult epilepsy: Implications for practice
    • Koutsogiannopoulos S, Adelson F, Lee V, Andermann F. 2009. Stressors at the onset of adult epilepsy: Implications for practice. Epileptic Disord 11: 42-47.
    • (2009) Epileptic Disord , vol.11 , pp. 42-47
    • Koutsogiannopoulos, S.1    Adelson, F.2    Lee, V.3    Ermann, F.4
  • 46
    • 80053920088 scopus 로고    scopus 로고
    • Marked strain and substrain differences in induction of status epilepticus and subsequent development of neurodegeneration, epilepsy, and behavioral alterations in rats [corrected]
    • Langer M, Brandt C, Loscher W. 2011. Marked strain and substrain differences in induction of status epilepticus and subsequent development of neurodegeneration, epilepsy, and behavioral alterations in rats [corrected]. Epilepsy Res 96: 207-224.
    • (2011) Epilepsy Res , vol.96 , pp. 207-224
    • Langer, M.1    Brandt, C.2    Loscher, W.3
  • 47
    • 67349133654 scopus 로고    scopus 로고
    • How do cognition, emotion, and epileptogenesis meet? A study of emotional cognitive bias in temporal lobe epilepsy
    • Lanteaume L, Bartolomei F, Bastien-Toniazzo M. 2009. How do cognition, emotion, and epileptogenesis meet? A study of emotional cognitive bias in temporal lobe epilepsy. Epilepsy Behav 15: 218-224.
    • (2009) Epilepsy Behav , vol.15 , pp. 218-224
    • Lanteaume, L.1    Bartolomei, F.2    Bastien-Toniazzo, M.3
  • 49
    • 44949146204 scopus 로고    scopus 로고
    • Altered phase precession and compression of temporal sequences by place cells in epileptic rats
    • Lenck-Santini PP, Holmes GL. 2008. Altered phase precession and compression of temporal sequences by place cells in epileptic rats. J Neurosci 28: 5053-5062.
    • (2008) J Neurosci , vol.28 , pp. 5053-5062
    • Lenck-Santini, P.P.1    Holmes, G.L.2
  • 50
    • 0014212970 scopus 로고
    • Permanence of retrograde amnesia produced by electroconvulsive shock
    • Luttges MW, McGaugh JL. 1967. Permanence of retrograde amnesia produced by electroconvulsive shock. Science 156: 408-410.
    • (1967) Science , vol.156 , pp. 408-410
    • Luttges, M.W.1    McGaugh, J.L.2
  • 51
    • 77955090647 scopus 로고    scopus 로고
    • Evolution of the mutation rate
    • Lynch M. 2010. Evolution of the mutation rate. Trend Genet 26: 345-352.
    • (2010) Trend Genet , vol.26 , pp. 345-352
    • Lynch, M.1
  • 52
    • 60849094368 scopus 로고    scopus 로고
    • H channel-dependent deficit of u oscillation resonance and phase shift in temporal lobe epilepsy
    • Marcelin B, Chauviere L, Becker A, Migliore M, Esclapez M, Bernard C. 2009. h channel-dependent deficit of u oscillation resonance and phase shift in temporal lobe epilepsy. Neurobiol Dis 33: 436-447.
    • (2009) Neurobiol Dis , vol.33 , pp. 436-447
    • Marcelin, B.1    Chauviere, L.2    Becker, A.3    Migliore, M.4    Esclapez, M.5    Bernard, C.6
  • 53
    • 80052587330 scopus 로고    scopus 로고
    • Neuronrestrictive silencer factor-mediated hyperpolarizationactivated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy
    • McClelland S, Flynn C, Dube C, Richichi C, Zha Q, Ghestem A, Esclapez M, Bernard C, Baram TZ. 2011. Neuronrestrictive silencer factor-mediated hyperpolarizationactivated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. Ann Neurol 70: 454-464.
    • (2011) Ann Neurol , vol.70 , pp. 454-464
    • McClelland, S.1    Flynn, C.2    Dube, C.3    Richichi, C.4    Zha, Q.5    Ghestem, A.6    Esclapez, M.7    Bernard, C.8    Baram, T.Z.9
  • 54
    • 84929277598 scopus 로고    scopus 로고
    • The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes
    • McClelland S, Brennan GP, Dube C, Rajpara S, Iyer S, Richichi C, Bernard C, Baram TZ. 2014. The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes. eLife 3: e01267.
    • (2014) Elife , vol.3
    • McClelland, S.1    Brennan, G.P.2    Dube, C.3    Rajpara, S.4    Iyer, S.5    Richichi, C.6    Bernard, C.7    Baram, T.Z.8
  • 55
    • 84887149574 scopus 로고    scopus 로고
    • The brain on stress: Toward an integrative approach to brain, body, and behavior
    • McEwen BS. 2013. The brain on stress: Toward an integrative approach to brain, body, and behavior. Perspect Psychol Sci 8: 673-675.
    • (2013) Perspect Psychol Sci , vol.8 , pp. 673-675
    • McEwen, B.S.1
  • 56
    • 0026251951 scopus 로고
    • Diathesis-stress theories in the context of life stress research: Implications for the depressive disorders
    • Monroe SM, Simons AD. 1991. Diathesis-stress theories in the context of life stress research: Implications for the depressive disorders. Psychol Bull 110: 406-425.
    • (1991) Psychol Bull , vol.110 , pp. 406-425
    • Monroe, S.M.1    Simons, A.D.2
  • 57
    • 70349096650 scopus 로고    scopus 로고
    • Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection
    • Monti B, Polazzi E, Contestabile A. 2009. Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection. Curr Mol Pharmacol 2: 95-109.
    • (2009) Curr Mol Pharmacol , vol.2 , pp. 95-109
    • Monti, B.1    Polazzi, E.2    Contestabile, A.3
  • 58
    • 84895882455 scopus 로고    scopus 로고
    • Epigenetic control and the circadian clock: Linking metabolism to neuronal responses
    • Orozco-Solis R, Sassone-Corsi P. 2014. Epigenetic control and the circadian clock: Linking metabolism to neuronal responses. Neuroscience 264: 76-87.
    • (2014) Neuroscience , vol.264 , pp. 76-87
    • Orozco-Solis, R.1    Sassone-Corsi, P.2
  • 59
    • 0032519868 scopus 로고    scopus 로고
    • Neuronal expression of zinc finger transcription factor REST/ NRSF/XBR gene
    • Palm K, Belluardo N, Metsis M, Timmusk T. 1998. Neuronal expression of zinc finger transcription factor REST/ NRSF/XBR gene. J Neurosci 18: 1280-1296.
    • (1998) J Neurosci , vol.18 , pp. 1280-1296
    • Palm, K.1    Belluardo, N.2    Metsis, M.3    Timmusk, T.4
  • 60
    • 84879756120 scopus 로고    scopus 로고
    • Somatic mutation, genomic variation, and neurological disease
    • Poduri A, Evrony GD, Cai X, Walsh CA. 2013. Somatic mutation, genomic variation, and neurological disease. Science 341: 1237758.
    • (2013) Science , vol.341
    • Poduri, A.1    Evrony, G.D.2    Cai, X.3    Walsh, C.A.4
  • 62
    • 13744259954 scopus 로고    scopus 로고
    • Similar network activity from disparate circuit parameters
    • Prinz AA, Bucher D, Marder E. 2004. Similar network activity from disparate circuit parameters. Nat Neurosci 7: 1345-1352.
    • (2004) Nat Neurosci , vol.7 , pp. 1345-1352
    • Prinz, A.A.1    Bucher, D.2    Marder, E.3
  • 63
    • 0031841852 scopus 로고    scopus 로고
    • Temporal distribution of partial seizures: Comparison of an animal model with human partial epilepsy
    • Quigg M, Straume M, Menaker M, Bertram EH III, 1998. Temporal distribution of partial seizures: Comparison of an animal model with human partial epilepsy. Ann Neurol 43: 748-755.
    • (1998) Ann Neurol , vol.43 , pp. 748-755
    • Quigg, M.1    Straume, M.2    Menaker, M.3    Bertram, E.H.4
  • 64
    • 77952887283 scopus 로고    scopus 로고
    • Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis
    • Qureshi IA, Mehler MF. 2010. Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis. Neurobiol Dis 39: 53-60.
    • (2010) Neurobiol Dis , vol.39 , pp. 53-60
    • Qureshi, I.A.1    Mehler, M.F.2
  • 65
    • 0000385942 scopus 로고    scopus 로고
    • Neurological disease: Listening to gene silencers
    • Roopra A, Huang Y, Dingledine R. 2001. Neurological disease: Listening to gene silencers. Mol Interv 1: 219-228.
    • (2001) Mol Interv , vol.1 , pp. 219-228
    • Roopra, A.1    Huang, Y.2    Dingledine, R.3
  • 66
    • 84880935246 scopus 로고    scopus 로고
    • Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor andNMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus
    • Ryley Parrish R, Albertson AJ, Buckingham SC, Hablitz JJ, Mascia KL, Davis Haselden W, Lubin FD. 2013. Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor andNMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus. Neuroscience 248: 602-619.
    • (2013) Neuroscience , vol.248 , pp. 602-619
    • Ryley Parrish, R.1    Albertson, A.J.2    Buckingham, S.C.3    Hablitz, J.J.4    Mascia, K.L.5    Davis Haselden, W.6    Lubin, F.D.7
  • 67
    • 84880398519 scopus 로고    scopus 로고
    • The epigenetic language of circadian clocks
    • Sahar S, Sassone-Corsi P. 2013. The epigenetic language of circadian clocks. Handb Exp Pharmacol 217: 29-44.
    • (2013) Handb Exp Pharmacol , vol.217 , pp. 29-44
    • Sahar, S.1    Sassone-Corsi, P.2
  • 69
    • 84892955609 scopus 로고    scopus 로고
    • Neurobiology of depression as a comorbidity of epilepsy
    • (ed. Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV). National Center for Biotechnology Information, Bethesda, MD
    • Sankar R, Mazarati A. 2012. Neurobiology of depression as a comorbidity of epilepsy. In Jasper’s basic mechanisms of the epilepsies (ed. Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV). National Center for Biotechnology Information, Bethesda, MD.
    • (2012) Jasper’s Basic Mechanisms of the Epilepsies
    • Sankar, R.1    Mazarati, A.2
  • 72
    • 68349091505 scopus 로고    scopus 로고
    • The early life environment and the epigenome
    • Szyf M. 2009a. The early life environment and the epigenome. Biochim Biophys Acta 1790: 878-885.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 878-885
    • Szyf, M.1
  • 73
    • 65249157050 scopus 로고    scopus 로고
    • Epigenetics, DNA methylation, and chromatin-modifying drugs
    • Szyf M. 2009b. Epigenetics, DNA methylation, and chromatin-modifying drugs. Annu Rev Pharmacol Toxicol 49: 243-263.
    • (2009) Annu Rev Pharmacol Toxicol , vol.49 , pp. 243-263
    • Szyf, M.1
  • 74
    • 84865030854 scopus 로고    scopus 로고
    • Functional network changes in hippocampal CA1 after status epilepticus predict spatial memory deficits in rats
    • Tyler AL, Mahoney JM, Richard GR, Holmes GL, Lenck-Santini PP, Scott RC. 2012. Functional network changes in hippocampal CA1 after status epilepticus predict spatial memory deficits in rats. J Neurosci 32: 11365-11376.
    • (2012) J Neurosci , vol.32 , pp. 11365-11376
    • Tyler, A.L.1    Mahoney, J.M.2    Richard, G.R.3    Holmes, G.L.4    Lenck-Santini, P.P.5    Scott, R.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.