Epilepsy, suicidality, and psychiatric disorders: A bidirectional association

Annals of Neurology

Volumn 72, Issue 2, 2012, Pages 184-191

  Hesdorffer, Dale C ^a   Ishihara, Lianna ^b   Mynepalli, Lakshmi ^c   Webb, David J ^b   Weil, John ^b,e   Hauser, W Allen ^a,d  

^a Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c GlaxoSmithKline Pharmaceuticals Ltd   (India)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e Novartis Vaccines and Diagnostics   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ANXIETY; ARTICLE; CHILD; COMORBIDITY; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; ECZEMA; EPILEPSY; FEMALE; HUMAN; INCIDENCE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PREVALENCE; PRIORITY JOURNAL; PSYCHOSIS; SCHOOL CHILD; SUICIDE;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHILD; COHORT STUDIES; COMORBIDITY; CONFIDENCE INTERVALS; EPILEPSY; FEMALE; GREAT BRITAIN; HUMANS; INCIDENCE; MALE; MENTAL DISORDERS; MIDDLE AGED; SUICIDE; YOUNG ADULT;

EID: 84865595762     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.23601     Document Type: Article

References (38)

1. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Translational Sciences, Office of Biostatistics. Statistical review and evaluations: Antiepileptic drugs and suicidality. Available online at http://www.fda.gov/ downloads/Drugs/DrugSafety/ PostmarketDrugSafetyInformationforPatientsandProviders/UCM192556.pdf. Accessed on April 25, 2012.
2. Hesdorffer DC, Kanner AM,. The FDA alert on suicidality and antiepileptic drugs: fire or false alarm? Epilepsia 2009; 50: 978-986.
3. Forsgren L, Bucht G, Eriksson S, Bergmark L,. Incidence and clinical characterization of unprovoked seizures in adults: a prospective population-based study. Epilepsia 1996; 37: 224-229. (Pubitemid 26071822)
4. Hesdorffer DC, Hauser WA, Olafsson E, et al. Depression and suicide attempt as risk factors for incident unprovoked seizures. Ann Neurol 2005; 59: 35-41.
5. Nilsson FM, Kessing LV, Bolwig TG,. On the increased risk of developing late-onset epilepsy for patients with major affective disorder. J Affect Disord 2003; 76: 39-48. (Pubitemid 37013354)
6. Forsgren L, Nystrom L,. An incident case-referent study of epileptic seizures in adults. Epilepsy Res 1990; 6: 66-81. (Pubitemid 20172108)
7. Hitiris N, Mohanraj R, Norrie J, et al. Predictors of pharmacoresistant epilepsy. Epilepsy Res 2007; 75: 192-196. (Pubitemid 47048664)
8. Kanner AM, Byrne R, Chicharro A, et al. A lifetime psychiatric history predicts a worse seizure outcome following temporal lobectomy. Neurology 2009; 72: 793-799.
9. Jick H, Jick SS, Derby LE,. Validation of information recorded on general practitioner based computerised data resource in the United Kingdom. BMJ 1991; 302: 766-768.
10. Jick SS, Kaye JA, Vasilakis-Scaramozza C, et al. Validity of the general practice research database. Pharmacotherapy 2003; 23: 686-689. (Pubitemid 36539051)
11. Kessler RC, Zhao S, Katz SJ, et al. Past-year use of outpatient services for psychiatric problems in the National Comorbidity Survey. Am J Psychiatry 1999; 156: 115-123. (Pubitemid 29034888)
12. Breslow NE, Day NE,. Statistical methods in cancer research. Volume II: The design and analysis of cohort studies. Lyon, France: International Agency for Research on Cancer, 1987.
13. Beghi E, Spagnoli P, Airoldi L, et al. Emotional and affective disturbances in patients with epilepsy. Epilepsy Behav 2002; 3: 255-261.
14. Boylan LS, Flint LA, Labovitz DL, et al. Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy. Neurology 2004; 62: 258-261. (Pubitemid 38167135)
15. Tellez-Zenteno JF, Patten SB, Jette N, et al. Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia 2007; 48: 2336-2344. (Pubitemid 350243401)
16. Baker GA, Jacoby A, Chadwick DW,. The associations of psychopathology in epilepsy: a community study. Epilepsy Res 1996; 25: 29-39. (Pubitemid 26292677)
17. Hermann BP, Whitman S, Wyler AR, et al. Psychosocial predictors of psychopathology in epilepsy. Br J Psychiatry 1990; 156: 98-105. (Pubitemid 20028160)
18. Hesdorffer DC, Ludvigsson P, Olafsson E, et al. ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Arch Gen Psychiatry 2004; 61: 731-736. (Pubitemid 38890808)
19. Qin P, Xu H, Laursen TM, et al. Risk for schizophrenia and schizophrenia-like psychosis among patients with epilepsy: population based cohort study. BMJ 2005; 331: 23.
20. Vestergaard M, Pedersen CB, Christensen J, et al. Febrile seizures and risk of schizophrenia. Schizophr Res 2005; 73: 343-349. (Pubitemid 40093898)
21. Hesdorffer DC, Hauser WA, Annegers JF, Cascino G,. Major depression is a risk factor for seizures in older adults. Ann Neurol 2000; 47: 246-249. (Pubitemid 30078574)
22. Kanner AM,. Does a history of postictal psychosis predict a poor postsurgical seizure outcome? Epilepsy Curr 2009; 9: 96-97.
23. Bradvik L,. Suicide after suicide attempt in severe depression: a long-term follow-up. Suicide Life Threat Behav 2003; 33: 381-388. (Pubitemid 37543483)
24. Suominen K, Isometsa E, Suokas J, et al. Completed suicide after a suicide attempt: a 37-year follow-up study. Am J Psychiatry 2004; 161: 562-563. (Pubitemid 38326113)
25. Patorno E, Bohn RL, Wahl PM, et al. Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death. JAMA 2010; 303: 1401-1409.
26. Arana A, Wentworth CE, Ayuso-Mateos JL, Arellano FM,. Suicide-related events in patients treated with antiepileptic drugs. N Engl J Med 2010; 363: 542-551.
27. Friedman JI, Vrijenhoek T, Markx S, et al. CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy. Mol Psychiatry 2008; 13: 261-266. (Pubitemid 351272653)
28. Green EK, Grozeva D, Jones I, et al. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol Psychiatry 2010; 15: 1016-1022.
29. Magnusson A, Stordal E, Brodtkorb E, Steinlein O,. Schizophrenia, psychotic illness and other psychiatric symptoms in families with autosomal dominant nocturnal frontal lobe epilepsy caused by different mutations. Psychiatr Genet 2003; 13: 91-95. (Pubitemid 36724537)
30. Adachi N, Onuma T, Kato M, et al. Analogy between psychosis antedating epilepsy and epilepsy antedating psychosis. Epilepsia 2011; 52: 1239-1244.
31. Chang YT, Chen PC, Tsai IJ, et al. Bidirectional relation between schizophrenia and epilepsy: a population-based retrospective cohort study. Epilepsia 2011; 52: 2036-2042.
32. Nazareth I, King M, Haines A, et al. Accuracy of diagnosis of psychosis on general practice computer system. BMJ 1993; 307: 32-34. (Pubitemid 23181093)
33. Herrett E, Thomas SL, Schoonen WM, et al. Validation and validity of diagnoses in the General Practice Research Database: a systematic review. Br J Clin Pharmacol 2010; 69: 4-14.
34. Holden EW, Grossman E, Nguyen HT, et al. Developing a computer algorithm to identify epilepsy cases in managed care organizations. Dis Manag 2005; 8: 1-14. (Pubitemid 40316209)
35. Martinez C, Sullivan T, Hauser WA,. Prevalence of acute repetitive seizures (ARS) in the United Kingdom. Epilepsy Res 2009; 87: 137-143.
36. Banerjee PN, Filippi D, Allen Hauser W,. The descriptive epidemiology of epilepsy: a review. Epilepsy Res 2009; 85: 31-45.
37. Chowdhury FA, Nashef L, Elwes RD,. Misdiagnosis in epilepsy: a review and recognition of diagnostic uncertainty. Eur J Neurol 2008; 15: 1034-1042.
38. Khan NF, Harrison SE, Rose PW,. Validity of diagnostic coding within the General Practice Research Database: a systematic review. Br J Gen Pract 2010; 60: e128-e136.